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SARS-CoV-2 mutations impact T-cell recognition of virus

A new research paper posted to the bioRxiv preprint server deals with the impact of these mutations on adaptive cellular immunity.

14 Apr 2021

Aged bone marrow niche restrains function of rejuvenated HSCs, shows study

When leukemia strikes an older person, it is in part due to the aging of his or her hematopoietic stem cells (HSCs).

13 Apr 2021

Selecting SARS-CoV-2 inhibitors in human airway epithelial cells

In a recent article currently available on the bioRxiv* preprint server, researchers from Belgium and the U.S. demonstrated a robust replication model for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolates in primary human epithelial cells at the air-liquid interface and appraised the antiviral effect of selected viral replication inhibitors.

28 Mar 2021

New imaging technique can better identify the presence of residual cancers in rectal tissues

Rectal cancer, along with colon cancer, is the third-most common type of cancer in the United States, and treatment and surgery greatly affect the quality of life of patients.

26 Mar 2021

Mogrify wins Hewitsons Award for Innovation in Business and Price Bailey Award for Business of the Year at CambridgeshireLive Business Excellence Awards 2020

Mogrify has been awarded the Hewitsons Award for Innovation in Business and Price Bailey Award for Business of the Year.

From Mogrify 26 Mar 2021

Increased replicative fitness of SARS-CoV-2 UK strain in human bronchial cells

A recent study from France showed that the UK variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – also known as B.1.1.7 variant – can replicate much more efficiently in a reconstituted human bronchial epithelium, which may explain why it spreads so rapidly in the human population. The study is currently freely available on the bioRxiv preprint server.

24 Mar 2021

Researchers examine acriflavine's antiviral potential against SARS-CoV-2

Acriflavine is traditionally employed as a topical antiseptic, though has more recently been implicated as an antiviral agent at low doses, potentially by stimulating the production of interferon. In a new study recently uploaded to the bioRxiv* preprint server, the application of the drug to SARS-CoV-2 infection is investigated, demonstrating a broad activity towards a range of other betacoronaviruses.

24 Mar 2021

Clofazimine inhibits coronaviruses including SARS-CoV-2, study finds

Researchers at the University of Hong Kong found that Clofazimine, a lipophilic antimicrobial riminophenazine dye used in combination with agents like rifampicin and dapsone to treat leprosy, inhibits coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease.

21 Mar 2021

Immune-modified ex vivo platform can measure treatment response of ovarian cancer

KIYATEC, Inc researchers demonstrated that their immune-modified ex vivo platform can measure treatment response through direct interaction between a patient's cancer and infiltrating immune cells, and immuno-oncology agents.

12 Mar 2021

Pancreatitis drug blocks SARS-CoV-2 activators in the upper respiratory tract

Pancreatitis drug Camostat inhibits new SARS-CoV-2 activators identified in the upper respiratory tract. There are no therapeutics available that have been developed for COVID-19 treatment.

5 Mar 2021

Virus-specific cellular immunity may be essential for long-term protection against SARS-CoV-2

Researchers from China and the US recently synthesized select peptide pools of the structural and functional proteins of SARS-CoV-2, including spike (S), envelope (E), membrane (M), nucleocapsid (N), and protease (P) proteins as target antigens to assess COVID-19-specific immunity.

22 Feb 2021

New isolated lymphatic vessel lumen perfusion system to evaluate nanoparticle dynamics

Nanoparticles used in drug delivery systems, bioimaging, and regenerative medicine migrate from tissues to lymphatic vessels after entering the body, so it is necessary to clarify the interaction between nanoparticles and lymphatic vessels.

20 Feb 2021

Researchers engineer "Nanotraps" that block SARS-CoV-2 infection

Researchers at Chicago University have developed an innovative new anti-SARS-CoV-2 therapy called “Nanotraps” – a family of nano-enabled virus-trapping particles – which have shown positive results in vitro, in vivo, and in human ex vivo trials.

3 Feb 2021

New technology uses near-infrared imaging and machine learning to find hidden tumors

Tumors can be damaging to surrounding blood vessels and tissues even if they're benign. If they're malignant, they're aggressive and sneaky, and often irrevocably damaging. In the latter case, early detection is key to treatment and recovery.

3 Feb 2021

Mogrify enters research collaboration with the MRC Laboratory of Molecular Biology

Mogrify Limited and the MRC Laboratory of Molecular Biology (LMB), today announced an exploratory research collaboration.

11 Jan 2021

NET study: New theranostic approach effective in reducing tumor volume and extending lifespan

A pair of copper radionuclides that target the somatostatin receptor overexpressed in neuroendocrine tumors has proven successful in identifying tumors and improving survival.

16 Dec 2020

Research breakthrough dispels concerns that human stem cells contain cancer-causing mutations

Pioneering new research has made a pivotal breakthrough that dispel concerns that human stem cells could contain cancer-causing mutations.

14 Dec 2020

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

Clinical investigators from Hackensack Meridian Health John Theurer Cancer Center (JTCC), a member of the Georgetown Lombardi Comprehensive Cancer Center consortium, are to present updates on treatment advances in multiple myeloma (MM), mantle cell lymphoma (MCL), and other types of B-cell lymphoma (BCL) as well as leukemia at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, to be held virtually from December 5-8, 2020.

7 Dec 2020

Scientists develop new technique to measure tissue oxygen levels

Tissue oxygenation is a measure of the oxygen level in biological tissue and is a useful clinical biomarker for tissue viability. Abnormal levels may indicate the presence of conditions such as sepsis, diabetes, viral infection, or pulmonary disease, and effective monitoring is important for surgical guidance as well as medical care.

2 Dec 2020

Virus induced lymphocytes show promise for COVID-19 and future pandemics

Researchers in the United States have conducted a study demonstrating the potential of a novel therapeutic approach to treating coronavirus disease 2019 (COVID-19). The therapy augments the body’s T cell response to the causative agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by providing a boost of rapidly expanded virus-specific T cells.

30 Nov 2020