Fecal Microbiota Transplantation News and Research

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Fecal microbiota transplantation effective against ICI-associated colitis

For the first time, transplanting gut bacteria from healthy donors was used to successfully treat patients suffering from severe colitis caused by treatment with immune checkpoint inhibitors.

12 Nov 2018

Auto-FMT found to be safe, effective way to replenish beneficial gut bacteria in cancer patients

Researchers at Memorial Sloan Kettering Cancer Center have shown that autologous fecal microbiota transplantation (auto-FMT) is a safe and effective way to help replenish beneficial gut bacteria in cancer patients who require intense antibiotics during allogenic hematopoietic stem cell transplantation.

27 Sep 2018

Innovation Fund Denmark supports research project that aims to fight Clostridium difficile diarrhea

One man's trash is another man's treasure, as the saying goes. If things go to plan, feces from registered and thoroughly tested healthy donors will in a few years be the standard treatment for the bacterium Clostridium difficile at Danish hospitals.

21 Sep 2018

Microbiotica partners with University of Adelaide to develop defined bacterial product for ulcerative colitis

Microbiotica, a leading player in microbiome-based therapeutics, today announced that it has entered into an agreement with University of Adelaide as part of its program to develop a defined bacterial product for ulcerative colitis (UC). Financial details have not been disclosed.

19 Jun 2018

Single FMT enema produces sustained and significant improvements in cognitive function

A single treatment using an optimized, targeted form of faecal microbiota transplantation (FMT) produces sustained clinical and cognitive improvements, according to the results of a long-term follow-up of patients with liver cirrhosis and hepatic encephalopathy (HE) who had participated in a short-term study.

16 Apr 2018

Scientists develop physiological approach to restore gut’s ecosystem in various diseases

The trillions of microbes living in a mammal's intestine play an important role in the host's metabolism and immunity. The composition of microbiota is maintained by antimicrobial proteins secreted from intestinal cells.

24 Oct 2017

Study finds increasing incidence of multiple recurring C. difficile infections

Intestinal infection with the bacterium Clostridium difficile is the most frequent healthcare-linked infection in the United States. Each year it afflicts about half a million Americans, causes tens of thousands of deaths, and costs the nation's healthcare system an estimated $5 billion.

4 Jul 2017

UAB researchers demonstrate persistence of donor microbes in recipients after fecal transplant

University of Alabama at Birmingham researchers have made the first direct demonstration that fecal donor microbes remained in recipients for months or years after a transplant to treat the diarrhea and colitis caused by recurrent Clostridium difficile infections -- a serious and stubborn cause of diarrhea after an antibiotic treatment for some other illness.

14 Jun 2017

Fecal microbiota transplant may be effective treatment option for ulcerative colitis, research suggests

A single transplant of microbes contained in the stool of a healthy donor is a safe and effective way to increase diversity of good bacteria in the guts of patients with ulcerative colitis, according to new research from Weill Cornell Medicine and NewYork-Presbyterian.

27 Apr 2017

Pill form of C-diff treatment could be effective, easier for patients and physicians, study shows

Frozen and freeze-dried products for Fecal Microbiota Transplantation are nearly as effective as fresh product at treating patients with Clostridium difficile infection, according to researchers at The University of Texas Health Science Center at Houston School of Public Health and Kelsey Research Foundation.

14 Mar 2017

Study examines fecal microbiota transplantation as treatment option for recurrent C. difficile infections

Patients suffering from infection of the bowel with the Gram-positive bacillus Clostridium difficile often have recurrent infections despite antibiotic treatment.

30 Sep 2016

Transplanted human stool may offer treatment hope for ulcerative colitis patients

Patients with ulcerative colitis (UC) may improve their symptoms with a transplantation of healthy stool from donors, according to Australian researchers. The findings were presented by Dr Sudarchan Paramsothy MD, a gastroenterologist from the University of New South Wales, Australia at the Digestive Disease Week conference in San Diego, California between the 21st to 24th May.

24 May 2016

Changes in intestinal microbiota linked to primary sclerosing cholangitis

Primary sclerosing cholangitis, also known as PSC, is a liver disease with no effective medical treatment. Liver transplantation is the only proven long-term treatment of PSC, although only a fraction of individuals with PSC will ultimately require it.

23 May 2016

New findings on gut microbiota to be discussed at 2016 Gut Microbiota for Health World Summit

Novel approaches for manipulating the gut microbiota through diet, pre- and probiotics, targeted antibiotic therapy and fecal microbiota transplantation for health maintenance and treatment are under investigation or already in use.

22 Feb 2016

Frozen fecal transplantation effective at providing relief to C. diff patients

Frozen fecal transplantation is effective at providing relief to Clostridium difficile (C. diff) patients, according to a new study co-authored by University of Guelph researchers.

18 Jan 2016

Two new studies show that fecal transplantation may help fight against ulcerative colitis

Two new studies led by researchers from the Farncombe Family Digestive Health Research Institute at McMaster University show that transplantation of fecal matter may be a useful tool in the fight against ulcerative colitis (UC).

3 Jul 2015

Fecal microbiota transplantation more successful for treating Clostridium difficile infections

Distasteful though it sounds, the transplantation of fecal matter is more successful for treating Clostridium difficile infections than previously thought.

30 Mar 2015

Risks and benefits of fecal microbiota transplant

A woman successfully treated for a recurrent Clostridium difficile infection with stool from an overweight donor rapidly gained weight herself afterwards, becoming obese, according to a case report published in the new journal Open Forum Infectious Diseases.

9 Feb 2015

Study shows potential of treating recurrent CDI with frozen fecal matter

A preliminary study has shown the potential of treating recurrent Clostridium difficile infection (a bacterium that is one of the most common causes of infection of the colon) with oral administration of frozen encapsulated fecal material from unrelated donors, which resulted in an overall rate of resolution of diarrhea of 90 percent, according to a study published in JAMA.

13 Oct 2014

Fecal microbiota transplantation officially recommended for effective treatment of C. difficile infection

The transplantation of faecal microbiota from a healthy donor has been shown in recent clinical studies to be a safe and highly effective treatment for recurrent Clostridium difficile (C. difficile) infection and is now recommended in European treatment guidelines.

29 Sep 2014