Fibroblast News and Research

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Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

Universal gene signaling mechanism identified by UB molecular researchers

A novel gene signaling mechanism that controls whether a stem cell develops into its destined tissue or fails to differentiate and becomes cancer has been identified by researchers in the multi-laboratory Molecular and Structural Neurobiology and Gene Therapy Program based at the University at Buffalo.

14 Aug 2008

New, previously unrecognized source of heart stem cells discovered

Researchers at Children's Hospital Boston are continuing to document the heart's earliest origins. Now, they have pinpointed a new, previously unrecognized group of stem cells that give rise to cardiomyocytes, or heart muscle cells. These stem cells, located in the surface of the heart, or epicardium, advance the hope of being able to regenerate injured heart tissue.

23 Jun 2008

Why some treatments rescue aging skin

Fine wrinkles, deeper creases, saggy areas around the mouth and neck - the sights in the mirror that make baby boomers wince - are not inevitable. They result from a structural breakdown inside the skin that some existing treatments effectively counteract by stimulating the growth of new, youthful collagen, University of Michigan scientists say.

28 May 2008

FGFR2 gene increases susceptibility to breast cancer

Much work has been done to identify genetic variations that predispose women to breast cancer. Previous work showed that variants in the gene called fibroblast growth factor receptor 2 (FGFR2) were associated with increased risk of the disease, but how these variants translated into increased risk was unknown.

6 May 2008

New model for embryonic limb development

A study led by a researcher at the University of Southern California has found a new model to explain how signals between cells in the embryo control limb development.

30 Apr 2008

Discovery of new way to prevent cardiac fibrosis

In a study that points to a new strategy for preventing or possibly reversing fibrosis - the scarring that can lead to organ and tissue damage - researchers at the University of California, San Diego School of Medicine have determined that a molecule called Epac (Exchange protein activated by cAMP1), plays a key role in integrating the body’s pro- and anti-fibrotic response.

22 Apr 2008

Mature B cells reprogrammed to stem-cell-like state

Fully mature, differentiated B cells can be reprogrammed to an embryonic-stem-cell-like state, without the use of an egg, according to a study published in the April 18 issue of Cell.

18 Apr 2008

Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency

Fully mature, differentiated B cells can be reprogrammed to an embryonic-stem-cell-like state, without the use of an egg according to a study published in the April 18 issue of Cell.

17 Apr 2008

Drugs in the pipeline: new therapies that could change treatment strategies

The investigational drug AZD2171 (cediranib) may help shrink tumors and prolong survival of patients with a relatively common, aggressive type of brain cancer, according to results from a clinical trial conducted by Boston researchers.

16 Apr 2008

New understanding of systemic sclerosis

Systemic sclerosis (SSc), also known as scleroderma, is characterized by the formation of fibrosis, or scar tissue, on internal organs as well as the skin.

15 Apr 2008

Protein sulfatase 2 a possible treatment target for liver cancer recurrence and survival

Deadly and difficult to treat, liver cancer has long resisted attempts by researchers to develop ways to prolong life and prevent recurrence.

11 Apr 2008

Molecule delivery method improves stem cell differentiation

Embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease.

10 Apr 2008

Method to deliver molecules within embryonic stem cells improves differentiation

Embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease.

10 Apr 2008

Common molecule tRNA involved in building protein can trigger cancer

Cancer Research UK scientists have discovered that a common molecule previously known to play a fundamental role in building protein, can also trigger cancer.

7 Apr 2008

Mutant proteins could lead to new treatment for heart disease

Heart damage due to blocked arteries remains the leading cause of disease and death in the Western world, but a Florida State University College of Medicine researcher is helping to open new pathways toward treating the problem.

25 Mar 2008

New mechanical insights into wound healing and scar tissue formation

New research published today in the Journal of Cell Biology illuminates the mechanical factors that play a critical role in the differentiation and function of fibroblasts, connective tissue cells that play a role in wound healing and scar tissue formation.

18 Dec 2007

Growth factor receptor affects prostate cancer progression

Breeding mice with a gene for a cellular receptor that can be turned on and off-at will-not only enabled researchers at Baylor College of Medicine in Houston to show how prostate cancer progresses, but also provides a model for studying when a drug targeting a gene will have an effect on the cancer.

10 Dec 2007