Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Researchers identify stem cells responsible for lung regeneration

Guided by insights into how mice recover after H1N1 flu, researchers at Harvard Medical School and Brigham and Women's Hospital, together with researchers at A*STAR of Singapore, have cloned three distinct stem cells from the human airways and demonstrated that one of these cells can form into the lung's alveoli air sac tissue.

28 Oct 2011

Blood biomarker panel can predict survival in IPF patients

A panel of blood proteins can predict which patients with the progressive lung disease idiopathic pulmonary fibrosis (IPF) are likely to live at least five years or to die within two years, say researchers at the University of Pittsburgh School of Medicine and Centocor R&D.

27 Oct 2011

European CHMP adopts positive opinion for Pharmaxis Bronchitol Marketing Authorisation

Pharmaceutical company Pharmaxis today announced the Committee for Medicinal Products for Human Use has adopted a positive opinion recommending the granting of a Marketing Authorisation for Bronchitol, clearing the way for the product to be used in Europe "for the treatment of cystic fibrosis in adults as an add-on therapy to best standard of care."

24 Oct 2011

Vertex initiates INCIVEK combination Phase 3b study for hepatitis C

Vertex Pharmaceuticals Incorporated today announced the initiation of a Phase 3b study called CONCISE that will evaluate the potential for treatment with INCIVEK (telaprevir) combination therapy to be shortened to 12 weeks in people with genotype 1 chronic hepatitis C who have the 'CC' variation near the IL28B gene.

24 Oct 2011

Synergy commences plecanatide Phase II/III trial in chronic idiopathic constipation

Synergy Pharmaceuticals, Inc., a developer of new drugs to treat gastrointestinal (GI) disorders and diseases, today announced initiation of dosing of patients in a major Phase II/III clinical trial of plecanatide to treat chronic idiopathic constipation.

24 Oct 2011

Proper daily care and maintenance of central lines might reduce infection rate in PICUs

By following a few basic rules for handling central venous catheters, nurses and doctors at a group of children's hospitals have, in three years, prevented nearly a thousand infections and saved more than a hundred children's lives and millions of dollars, according to a study by investigators at Johns Hopkins Children's Center and elsewhere.

24 Oct 2011

NIH stops triple-drug therapy clinical trial for idiopathic pulmonary fibrosis

The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, has stopped one arm of a three arm multi-center, clinical trial studying treatments for the lung-scarring disease idiopathic pulmonary fibrosis (IPF) for safety concerns.

22 Oct 2011

RCSI study: Alpha-1 antitrypsin deficiency more prevalent in Ireland

Researchers from the Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, and Trinity College Dublin have conducted a study which has found that Ireland has one of the highest incidences in the world of a genetic condition that causes severe hereditary emphysema.

20 Oct 2011

Coughing may signal trouble for patients with idiopathic pulmonary fibrosis

A new analysis has found that coughing may signal trouble for patients with the lung-scarring disease known as idiopathic pulmonary fibrosis. The study, published in the journal Respirology, found that patients with the condition who also cough are more likely to develop advanced forms of the disease that may be life threatening.

19 Oct 2011

PFF establishes Research Fund to Cure Pulmonary Fibrosis

The Pulmonary Fibrosis Foundation (PFF) announced today that it has established the PFF Research Fund to Cure Pulmonary Fibrosis, a fund created to support research that will assist in the development of successful therapies for pulmonary fibrosis.

18 Oct 2011

Most technoelectric dependent children not prepared for power failure

Children dependent on electrically powered medical devices for life support and maintenance are vulnerable to an unexpected loss of power - and their parents are ill-prepared to deal with it, according to an abstract presented Sunday, Oct. 16, at the American Academy of Pediatrics (AAP) National Conference and Exhibition in Boston.

18 Oct 2011

New series on child abuse on UBM Medica's Pediatrics Consultant Live

UBM Medica's Pediatrics Consultant Live has a new series called "Child Abuse–or Mimic?" which helps clinicians distinguish cases of child abuse from pediatric disease or mere accidents.

15 Oct 2011

UEI tool could allow doctors to deliver efficient, timely treatment for Crohn's disease

It's difficult for doctors to tell whether a patient with Crohn's disease has intestinal fibrosis, which requires surgery, or inflammation, which can be treated with medicine. A new imaging method might make that task easier, according to a U-M-led study.

15 Oct 2011

NIH-funded study to evaluate rescue medications for victims of toxic gases

National Jewish Health researchers have received nearly $13 million from the National Institutes of Health to evaluate potential rescue medications for victims of terrorist attacks, wartime use of toxic gases, and/or inhalation disasters. The gases of greatest interest in these studies will be 'mustard gas' (sulfur mustard) and chlorine gas.

14 Oct 2011

Cigarette smoke interferes with Cystic Fibrosis Transmembrane Conductance Regulator protein

If you smoke cigarettes, you have more in common with someone who has cystic fibrosis than you think. A new research report appearing online in the FASEB Journal shows that smoking cigarettes affects the lungs in a way that is very similar to cystic fibrosis, a life threatening disease affecting the lungs and other organs.

13 Oct 2011

Simmons Center to evaluate CGEN-25009 for treatment of idiopathic pulmonary fibrosis

Compugen Ltd. and the Pulmonary Fibrosis Foundation announced today that the Pulmonary Fibrosis Foundation will provide a grant to scientists at the University of Pittsburgh Dorothy P. and Richard P.

13 Oct 2011

Vertex announces availability of INCIVEK to treat hepatitis C in Canada

Vertex Pharmaceuticals Incorporated announced today that INCIVEK (telaprevir) tablets are now available in Canada for people with genotype 1 chronic hepatitis C with compensated liver disease, including cirrhosis.

11 Oct 2011

Positive results from Biotron's BIT225 Phase 2a trial on HCV

Australian drug development company Biotron Limited has released headline results from its landmark Phase 2a trial of its lead drug candidate, BIT225 in Hepatitis C virus (HCV) infected patients.

11 Oct 2011

Vertex announces abstracts from hepatitis C program to be presented at The Liver Meeting

Vertex Pharmaceuticals Incorporated today announced that abstracts from its hepatitis C program, including two late-breaking posters from studies of INCIVEK (telaprevir) tablets and VX-222, were accepted for presentation at The Liver Meeting, the 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in San Francisco, November 4-8, 2011.

1 Oct 2011

Galectin posts new corporate video on galectin-inhibiting therapeutics to treat fibrosis and cancer

Galectin Therapeutics Inc. today announced that it posted a new corporate presentation video to its website, www.galectintherapeutics.com, that highlights the Company's leadership position in developing galectin-inhibiting therapeutics to treat fibrosis and cancer.

30 Sep 2011

Fibrosis News and Research

Further Reading

Researchers identify stem cells responsible for lung regeneration

Blood biomarker panel can predict survival in IPF patients

European CHMP adopts positive opinion for Pharmaxis Bronchitol Marketing Authorisation

Vertex initiates INCIVEK combination Phase 3b study for hepatitis C

Synergy commences plecanatide Phase II/III trial in chronic idiopathic constipation

Proper daily care and maintenance of central lines might reduce infection rate in PICUs

NIH stops triple-drug therapy clinical trial for idiopathic pulmonary fibrosis

RCSI study: Alpha-1 antitrypsin deficiency more prevalent in Ireland

Coughing may signal trouble for patients with idiopathic pulmonary fibrosis

PFF establishes Research Fund to Cure Pulmonary Fibrosis

Most technoelectric dependent children not prepared for power failure

New series on child abuse on UBM Medica's Pediatrics Consultant Live

UEI tool could allow doctors to deliver efficient, timely treatment for Crohn's disease

NIH-funded study to evaluate rescue medications for victims of toxic gases

Cigarette smoke interferes with Cystic Fibrosis Transmembrane Conductance Regulator protein

Simmons Center to evaluate CGEN-25009 for treatment of idiopathic pulmonary fibrosis

Vertex announces availability of INCIVEK to treat hepatitis C in Canada

Positive results from Biotron's BIT225 Phase 2a trial on HCV

Vertex announces abstracts from hepatitis C program to be presented at The Liver Meeting

Galectin posts new corporate video on galectin-inhibiting therapeutics to treat fibrosis and cancer

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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