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Discovery of potent class of anti-cancer compounds by Scripps Research and MIT scientists

Working as part of a public program to screen compounds to find potential medicines and other biologically useful molecules, scientists from The Scripps Research Institute and Massachusetts Institute of Technology (MIT) have discovered an extremely potent class of potential anti-cancer and anti-neurodegenerative disorder compounds.

8 Mar 2011

Caris Life Sciences to highlight new approaches for gynecologic cancers at SGO 2011 conference

Caris Life Sciences, Inc., a leading biosciences company focused on enabling precise and personalized healthcare through the highest quality anatomic pathology, molecular profiling, and blood-based diagnostic services, today announced highlights from the company's upcoming symposium, "Using Biomarker Expression to Guide Therapy: An Evidence-Based Approach for Gynecologic Cancers," at the Society of Gynecologic Oncologists 2011 Annual Meeting on Women's Cancer in Orlando, FL on March 6.

5 Mar 2011

Bessel beam plane illumination microscopy reveals 3-D structures of living cells

A new microscope invented by scientists at Howard Hughes Medical Institute's Janelia Farm Research Campus will let researchers use an exquisitely thin sheet of light -- similar to that used in supermarket bar-code scanners -- to peer inside single living cells, revealing the three-dimensional shapes of cellular landmarks in unprecedented detail.

5 Mar 2011

Agilent Technologies acquires Lab901

Agilent Technologies Inc. today announced it has acquired Lab901, a leading electrophoresis equipment and consumables company based in Edinburgh, U.K. The company's automated electrophoresis products are used for DNA, RNA and protein analysis. Financial details of the acquisition were not disclosed.

28 Feb 2011

New rapid and inexpensive test can effectively identify never-smoking group with lung adenocarcinoma

An inexpensive and rapid testing method can effectively identify a sub-group of never-smoking lung cancer patients whose tumors express a molecule associated with increased risk of disease progression or recurrence, US researchers have found.

25 Feb 2011

Multiplexed capillary isoelectric focusing increases efficiency in protein measurements

The Springer journal Analytical and Bioanalytical Chemistry (ABC) has chosen Oluwatosin O. Dada (34) as the recipient of its Best Paper Award 2010. Dada is the lead author of a paper in ABC on capillary isoelectric focusing. The award, accompanied by 1,000 euros, was created by Springer to help exceptional young scientists establish their research careers. The ABC Best Paper Award has been given since 2005.

24 Feb 2011

Nonsurgical methods to identify critical lymph nodes in patients with breast cancer

Researchers at the University of California, San Diego are developing nonsurgical methods for identifying critical lymph nodes to help doctors determine courses of treatment for breast cancer patients.

24 Feb 2011

Sleeping Trojan horse technique resolves some difficulties in transporting metal ions into cells

A unique strategy developed by researchers at Cardiff University is opening up new possibilities for improving medical imaging.

18 Feb 2011

BD announces addition of new flow cytometry system for rapid microbial enumeration, detection

Industrial microbiologists now have a new tool that was designed specifically to help quality control laboratories rapidly screen raw materials, as well as in-process and finished goods, for the presence of microorganisms that can threaten product quality.

17 Feb 2011

Study explores role of proline containing peptides in inhibiting anti-apoptotic function of XIAP

Basic and translational research on cancer, and development of new cancer therapeutics, has focused on different aspects of cancer cellular function. One area of focus is the life and death of a cancer cell. Apoptosis, also known as programmed cell death, is a fundamental process of cells including cancer cells. The signal transduction pathways of apoptosis involve many different proteins and their interactions with each other.

16 Feb 2011

New technique reveals spatial structure of microbial community

Like people in cities, microbes often live in complex communities that contain many different microbial types. Also like us, microbes tend to gravitate to and "hang out" with certain other types in their community, more than with the rest. And sometimes, when opportunities arise, they move to more favorable locations.

15 Feb 2011

New research: LED products actually contain hazardous substances

Those light-emitting diodes marketed as safe, environmentally preferable alternatives to traditional lightbulbs actually contain lead, arsenic and a dozen other potentially hazardous substances, according to newly published research.

13 Feb 2011

Study unveils surprising mechanism that controls brain formation

A study from The Scripps Research Institute has unveiled a surprising mechanism that controls brain formation. The findings have implications for understanding a host of diseases, including some forms of mental retardation, epilepsy, schizophrenia, and autism.

10 Feb 2011

Rapid detection of transiently folded single-molecule structures from 'intrinsically disordered proteins'

A team of scientists from The Scripps Research Institute and the University of California, San Diego (UCSD) have developed a novel technique to observe previously unknown details of how folded structures are formed from an intrinsically disordered protein. The insights could help scientists to better understand the mechanism of plaque formation in neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.

9 Feb 2011

Scientists develop novel technique to detect disordered protein folding

A team of scientists from The Scripps Research Institute and the University of California, San Diego have developed a novel technique to observe previously unknown details of how folded structures are formed from an intrinsically disordered protein.

9 Feb 2011

Single molecule FRET techniques combined with wavelet transforms give new view of AMPA receptor

A digital signal processing technique long used by statisticians to analyze data is helping Houston scientists understand the roots of memory and learning, Alzheimer's and Parkinson's diseases and stroke.

8 Feb 2011

TREK1 activity offers a key target for fluoxetine and other antidepressant drugs

Using a unique and relatively simple cell-based fluorescent assay they developed, scientists with the U.S. Department of Energy's Lawrence Berkeley National Laboratory and the University of California, Berkeley have identified a means by which fluoxetine, the active ingredient in Prozac, suppresses the activity of the TREK1 potassium channel.

8 Feb 2011

Human Vaccines journal publishes paper on Inovio's new DNA vaccine delivery technology

Inovio Pharmaceuticals, Inc., a leader in the development of therapeutic and preventive vaccines against cancers and infectious diseases, announced today that its new generation DNA vaccine delivery technology, which provides the powerful enabling capabilities of electroporation without contacting the skin, is highlighted in a paper published in the scientific journal Human Vaccines.

7 Feb 2011

Study: Fluorescent probe may serve as useful tool in future surgeries to repair injured nerves

Accidental damage to thin or buried nerves during surgery can have severe consequences, from chronic pain to permanent paralysis. Scientists at the University of California, San Diego School of Medicine may have found a remedy: injectable fluorescent peptides that cause hard-to-see peripheral nerves to glow, alerting surgeons to their location even before the nerves are encountered.

6 Feb 2011

Researchers trace scent signals from nose to higher centers of mouse brain

Mice know fear. And they know to fear the scent of a predator. But how do their brains quickly figure out with a sniff that a cat is nearby?

5 Feb 2011