Fluorescent Labeling News and Research

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New technology can rapidly analyze the metabolic state of lipids in cells

Professor Itaru Hamachi, Lecturer Tomonori Tamura, and Assistant Professor Masaki Tsuchiya of Kyoto University have developed a new technology called O-ClickFC (Organelle-selective click labeling with flow cytometry), which can, at a very high speed, analyze the metabolic state of lipids in cells.

27 Mar 2023

A fast and powerful method for the production of SARS-CoV-2 virus-like particles in insect cells

Researchers presented the direct plasmid transfection method for SARS-CoV-2 virus-like particle production in insect cells and applied the VLPs to evaluate the efficacy of monoclonal antibodies and vaccinated donor sera.

26 Sep 2022

Using Q-bodies for imaging intracellular proteins in live cells

Recent advances in imaging technology have made it possible to visualize intracellular dynamics, which offers a better understanding of several key biological principles for accelerating therapeutic development.

9 Sep 2022

Optical fiber holds promise for use in deep-tissue studies of patients’ brains with Alzheimer’s disease

An optical fiber as thin as a strand of hair holds promise for use in minimally invasive deep-tissue studies of patients' brains that show the effects Alzheimer's disease and other brain disorders.

30 Jun 2022

New insight into SARS-CoV-2 main protease opens door to new viral inhibitors

A recent study has revealed a full cycle of substrate cleavage for the main protease of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – providing, in turn, a steadfast foundation for developing potent new viral inhibitors. The paper was published in the journal Proceedings of the National Academy of Sciences (PNAS).

20 Apr 2022

How does the non-structural protein 1 affect COVID-19 pathogenicity?

Researchers discuss the effects of the SARS-CoV-2 non-structural protein 1 (Nsp1), which binds to the ribosomal subunit thus inhibiting translation.

20 Mar 2022

A novel multiplexed diagnostic approach for COVID-19

Researchers developed a platform for detecting the virus directly from a patient's sample as well as the immune response through antibodies such as IgG and IgM.

31 May 2021

New N501Y SARS-CoV-2 mutations increase binding to host cell receptor

A team of researchers used several assays, atomic force microscopy, and simulations to determine that the N501Y mutation in the virus’s receptor-binding domain (RBD) increased the interaction of the virus with the angiotensin-converting enzyme 2 (ACE2) receptor.

17 Feb 2021

Microplastic particles find their way into living cells if exposed to natural aquatic environments

The environment is polluted by microplastics worldwide. The tiny particles enter food chains, and thereby the digestive systems of animals and humans; moreover, they can be inhaled. Instead of being excreted, small microplastics can be incorporated into the body tissue.

10 Dec 2020

Engineers use electric fields to manipulate viruses in microfluidic device

The technique uses microfluidics -- the submillimeter control of fluids within a precise, geometric structure. On what is basically a tricked-out microscope slide, chemical engineers from Michigan Technological University have been able to manipulate viruses in a microfluidic device using electric fields.

3 Nov 2020

Newly developed fusion protein could improve COVID-19 research

Researchers at the Paul Scherrer Institute in Switzerland have developed a high-quality recombinant virus protein that could be applied in the development of vaccines against the 2019 novel coronavirus (2019-nCoV) and in the detection of novel viruses or antibodies.

30 Sep 2020

A map of SARS-CoV-2 escape mutations enables the development of therapeutic antibody cocktails

A recent tour-de-force study by the US researchers describes a comprehensive approach to completely map mutations to the SARS-CoV-2 receptor-binding domain (RBD) that escape antibody binding – enabling, in turn, rational design of antibody therapeutics and appraisal of the antigenic consequences of viral evolution. The results are currently available in a bioRxiv preprint paper.

13 Sep 2020

Next-Generation Microscopy Image Analysis with Deep-Learning Technology

Image analysis is a critical part of many life science applications. Analyses that rely on segmentation to extract targets, such as cells and organelles, from the rest of the image are commonplace.

From Evident Corporation - Life Sciences 8 Apr 2020

Microglia play a dual role in regulating the permeability of blood-brain barrier, study shows

The blood-brain barrier is a layer of cells that covers the blood vessels in the brain and regulates the entry of molecules from the blood into the brain.

28 Feb 2020

Simple blood test could be used by GPs to aid in earlier brain tumor diagnosis

A new simple blood test for brain tumors that could be used by GPs in primary care is being developed thanks to funding of nearly £500,000 by Cancer Research UK.

24 Feb 2020

Johns Hopkins engineers create new lens-free ultra-miniaturized endoscope

Johns Hopkins engineers have created a new lens-free ultra-miniaturized endoscope, the size of a few human hairs in width, that is less bulky and can produce higher quality images.

8 Dec 2019

High-speed imaging technology reveals previously unseen details of living creatures

The Columbia team behind the revolutionary 3D SCAPE microscope announces today a new version of this high-speed imaging technology.

27 Sep 2019

Study: Single protein regulates network of genes essential for sperm development

A single protein regulates a battery of key genes inside developing sperm, according to a new study out of Case Western Reserve University School of Medicine.

31 Oct 2018

Using stem cells extracted from baby teeth to regrow dental tissues

Sometimes kids trip and fall, and their teeth take the hit. Nearly half of children suffer some injury to a tooth during childhood. When that trauma affects an immature permanent tooth, it can hinder blood supply and root development, resulting in what is essentially a "dead" tooth.

12 Sep 2018

Stem cell secretions appear to protect retinal ganglion cells in rats, study shows

A new study in rats shows that stem cell secretions, called exosomes, appear to protect cells in the retina, the light-sensitive tissue in the back of the eye.

27 Jan 2017