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New insights into the exacerbation of psoriasis through specific genetic defects

The inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model.

27 Mar 2024

Bioengineering edible mycelium to enhance nutritional value, color, and flavor

A modular synthetic biology toolkit for Aspergillus oryzae, an edible fungus used in fermented foods.

21 Mar 2024

Microfluidic chips advance neurodegenerative disease research

Researchers review the role of microfluidic chip models in understanding neurodegenerative diseases, offering insights into the disease mechanisms and potential for drug development through innovative lab-on-a-chip technologies.

14 Mar 2024

Mapping the brain: How cell types and location influence Parkinson’s disease

A single-cell spatial transcriptome analysis on murine brain expression in age and disease using a Parkinson's disease.

27 Feb 2024

Breakthrough gene therapy method utilizes bird retrotransposon for safe gene insertion

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job knocking out genes to cure hereditary disease.

20 Feb 2024

Study reveals seasonal MERS-CoV peaks in Kenyan camels and potential human transmission

Researchers found biphasic peaks of MERS-CoV in dromedaries in Kenya, with evidence of serologic exposure among slaughterhouse workers, highlighting potential human transmission risks.

18 Feb 2024

Drug repurposing study finds lonafarnib effective against RSV

A study in Nature Communications identifies lonafarnib from the ReFRAME drug-repurposing library as a potent inhibitor of the RSV fusion protein, showing promise in reducing RSV infection in vitro and in vivo.

11 Feb 2024

Unlocking Alzheimer's secrets: Study pinpoints APOE4's harmful effect on lipids

UNC School of Medicine researcher Sarah Cohen, PhD, and Ian Windham, a former PhD student from the Cohen lab, have made a new discovery about apolipoprotein E (APOE) – the biggest genetic risk factor for late-onset Alzheimer's disease.

9 Feb 2024

Study shines light on partial endothelial-to-mesenchymal transition in the tumor microenvironment

Endothelial-mesenchymal transition (EndoMT, also termed as EndMT), a biological process resulting in the formation of mesenchymal (or lineage-committed) phenotypes from endothelial cells (lining blood vessels), plays a crucial role in tumor progression.

7 Feb 2024

Bioprinting breakthrough: Tech platform creates 3D neural tissues in which neurons and glia connect

Researchers produced 3D bioprinted human brain tissues, allowing for the creation of functioning neural networks that could simulate network activity in normal and pathological situations.

6 Feb 2024

Scientists develop noninvasive way to monitor gene expression dynamics in the brain

Researchers introduced a non-invasive, sensitive method for monitoring gene expression in the brain using engineered reporters called released markers of activity, which can exit the brain into the blood for easy detection.

12 Jan 2024

New Omicron subvariants test vaccine limits, reveal unique infection challenges

Study reveals that the Omicron subvariants BA.2.86 and FLip show unique mutations and infectivity profiles, with BA.2.86 being highly infectious and resistant to most conventional antibodies, underscoring the need for updated vaccines.

9 Jan 2024

First-of-its-kind research shines light on how certain pathogens can outwit the body's immune system

In a first-of-its-kind research breakthrough, a team of scientists at the University of Massachusetts Amherst has analyzed and described what they call the "mosquito effect," which sheds light on how certain pathogens, such as cancerous tumor cells, can outwit the body's immune system.

8 Jan 2024

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

Researchers developed an RNA-based switch, the pA regulator system, to control gene expression in mammalian cells by modulating synthetic polyA signal cleavage, offering a novel approach for gene therapy applications.

4 Jan 2024

Researchers produce artificial cells with potential for drug delivery and tissue engineering

Artificial cells, made with the use of synthetic materials, have been produced in international research led at the University of Strathclyde.

11 Dec 2023

Inhibitory interneurons play a crucial role in fear memory expression and recall

Memory, a fundamental tool for our survival, is closely linked with how we encode, recall, and respond to external stimuli.

8 Nov 2023

Proof-of-concept study holds promise for safer gene therapy techniques for treating immunodeficiencies

Researchers described an approach to edit the recombination-activating gene 2 (RAG2) locus for therapeutic applications.

1 Nov 2023

Researchers study how cells adapt to stressful and complex environments

Imagine the life of a yeast cell, floating around the kitchen in a spore that eventually lands on a bowl of grapes. Life is good: food for days, at least until someone notices the rotting fruit and throws them out.

16 Oct 2023

Researchers explore immunomodulating targets for improving glioblastoma therapies

Researchers have delved into the intricate heterogeneity of glioblastoma, a notoriously aggressive brain tumor, using advanced single-cell RNA sequencing and innovative zebrafish avatars. Their findings spotlighted the LGALS1 gene's role in immunosuppression and suggested potential therapeutic avenues for personalized GBM treatment.

8 Oct 2023

VAX-seq: the future of mRNA vaccine analysis and quality assurance?

Researchers proposed a simplified approach for analyzing mRNA vaccines using long-read sequencing.

22 Sep 2023