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Promising new treatment for bronchiectasis

Researchers have identified a promising new treatment for non-cystic fibrosis bronchiectasis, a long-term lung disorder which causes persistent coughing and breathlessness. The results, published in The Lancet, could represent an important advance in the treatment of this debilitating disease, for which very few evidence-based treatments are currently available.

17 Aug 2012

Mepolizumab almost halves exacerbations in severe asthma patients

The largest study of patients with severe asthma to date, published in The Lancet special issue on respiratory medicine, shows that those treated with the monoclonal antibody mepolizumab experienced an almost 50% reduction in severe exacerbations, emergency room visits, and hospitalisations compared with patients given placebo.

17 Aug 2012

Women with hypertension or obesity more likely to experience sleep apnoea

New research from Umeå and Uppsala universities has found high rates of sleep apnoea in women, despite the condition usually being regarded as a disorder predominantly of males.

16 Aug 2012

Genocea commences GEN-003 Phase 1/2a study in moderate-to-severe HSV-2 infection

Genocea Biosciences announced today that it has initiated a Phase 1/2a clinical study with its lead candidate, GEN-003. GEN-003 is an investigational vaccine designed to stimulate T cell and B cell immune responses to potentially reduce the frequency and severity of clinical outbreaks associated with moderate-to-severe Herpes Simplex Virus type 2 (HSV-2) infection.

16 Aug 2012

Neurostimulator a significant step in treating sleep apnea

At Charité - Universitätsmedizin Berlin the first tongue pacemaker was implanted Europe-wide that prevents pauses in breathing during sleep and helps against snoring. Physicians at the Department of Otolaryngology used the device for a patient who suffers from obstructive sleep apnea syndrome.

15 Aug 2012

Bullying linked with borderline personality disorder in children

UK study results suggest that children who are bullied by their peers in primary school have an increased risk for developing borderline personality disorder during childhood.

14 Aug 2012

Cardiovascular control continues despite low pulse pressure in LVAD patients

Patients implanted with continuous-flow left ventricular assist devices have low pulse pressure levels but are nevertheless able to maintain cardiovascular control through baroreflexes, German and US scientists have discovered.

14 Aug 2012

Low platelet count not associated with patent ductus arteriosus

Thrombocytopenia in the first 24 hours after birth is not linked to patent ductus arteriosus in low birthweight infants, research shows.

13 Aug 2012

Research on language gene seeks to uncover origins of the singing mouse

Singing mice (Scotinomys teguina) are not your average lab rats. Their fur is tawny brown instead of the common white albino strain; they hail from the tropical cloud forests in the mountains of Costa Rica; and, as their name hints, they use song to communicate.

12 Aug 2012

Utility of DMDD diagnosis in child psychiatric patients questioned

In children admitted to a psychiatric unit with serious behavioral problems, use of the new diagnosis concept of disruptive mood dysregulation disorder may go some way to reducing diagnoses of bipolar disorder, research shows.

10 Aug 2012

Worldwide data reveal gaps in elderly eye care

Worldwide eye examination rates among older adults are very low, despite this age group being recommended to have an eye test at least every 1–2 years, say researchers from Canada.

10 Aug 2012

Pulse oximetry detects sleep-disordered breathing in heart patients

Overnight pulse oximetry can be used to accurately diagnose sleep-disordered breathing in patients with chronic heart failure, UK research suggests.

10 Aug 2012

Korean meals may help dieters shed the pounds

Regularly incorporating Korean dishes into a mainly Western-style diet may be an effective way to lose weight, say researchers.

9 Aug 2012

Early maladaptive schemas play role in bipolar disorder functionality

Results from a Danish study suggest that seven early maladaptive schemas play a significant role in functional impairment among patients with bipolar disorder.

7 Aug 2012

Scientists discover biological marker that may help identify patients’ response to antidepressants

Scientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say National Institutes of Health researchers.

7 Aug 2012

Fainting appears to have strong genetic predisposition

Fainting has a strong genetic predisposition, according to new research published in the August 7, 2012, print issue of Neurology, the medical journal of the American Academy of Neurology. Fainting, also called vasovagal syncope, is a brief loss of consciousness when your body reacts to certain triggers, such as emotional distress or the sight of blood.

7 Aug 2012

New sequencing approach can provide more effective method of BRCA1/2 mutational analysis

Individuals with mutations in BRCA1 and BRCA2 genes have a significantly higher risk of developing breast and ovarian cancers. Families at risk have been seeking genetic testing and counseling based on their mutation carrier status, but the standard method of direct sequencing is labor-intensive, costly, and it only targets a part of the BRCA1 and BRCA2 genes.

6 Aug 2012

Mammalian cells divide when their growth rate hits a specific threshold

It's a longstanding question in biology: How do cells know when to progress through the cell cycle? In simple organisms such as yeast, cells divide once they reach a specific size. However, determining if this holds true for mammalian cells has been difficult, in part because there has been no good way to measure mammalian cell growth over time.

6 Aug 2012