Frontotemporal Dementia News and Research

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Researchers discover over 40 new genetic markers for Alzheimer’s disease

A new Nature Genetics study describes over 70 gene markers that appear to be significantly associated with AD risk using translational genomics.

6 Apr 2022

Researchers identify motor neuron toxin associated with ALS

An international team of investigators has discovered that an inorganic polyphosphate released by nerve cells known as astrocytes in people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) contributes to the motor neuron death that is the signature of these diseases.

10 Mar 2022

Evaluating the Seven Components of Wisdom

In this interview, we speak to Professor Dilip Jeste about what 'wisdom' actually is, how it can be assessed, and what this can mean for our health.

10 Mar 2022

Damage to general intelligence brain networks makes it difficult for dementia patients to cope with change

People with dementia struggle to adapt to changes in their environment because of damage to areas of the brain known as 'multiple demand networks', highly-evolved areas of the brain that support general intelligence, say scientists at the University of Cambridge.

9 Mar 2022

Patients divided over Alzheimer’s drug: Is it a ‘risk I’m willing to take’ or just a ‘magic pill’?

If you listen to the nation's largest Alzheimer's disease advocacy organizations, you might think everyone living with Alzheimer's wants unfettered access to Aduhelm, a controversial new treatment.

7 Mar 2022

Novel molecular pathway shared by two neurodegenerative disorders discovered

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia.

28 Feb 2022

Research reveals why a common genetic variant worsens outcomes for people with ALS and FTD

A pioneering new study led by UCL and National Institutes of Health (NIH) scientists has revealed, for the first time, why a common genetic variant worsens disease outcomes for people with the devastating adult-onset neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

24 Feb 2022

Being fit can protect older people against mild cognitive impairment

Seventy- to eighty-year-olds who train for better fitness are better at solving cognitive tasks and are less likely to suffer cognitive impairment.

10 Feb 2022

Relationship between SARS-CoV-2 neurotropism and Alzheimer's disease

In a new study, researchers evaluated the neurotropism of SARS-CoV-2 and its impact on COVID-19 patients with and without neurological disorders like Alzheimer's disease.

3 Feb 2022

Tau mapping offers potential treatment targets and biomarkers for dementia and Alzheimer disease

By mapping all the protein interactions of a dementia-linked protein in the brain called Tau, a team of Weill Cornell Medicine investigators has created a road map for identifying potential new treatment targets for Alzheimer's disease and related dementia.

21 Jan 2022

Researchers uncover new findings about the role of tau in neurodegenerative disease

Utilizing cutting-edge proteomics, researchers at the Buck Institute and elsewhere have mapped the "tau interactome" uncovering new findings about the role of tau in neurodegenerative disease. Publishing in Cell, scientists found that mutant tau impacts the function of mitochondria in human neurons.

20 Jan 2022

Combination of rifampicin and resveratrol helps stop dementia, finds study

Dementia is thought to occur when proteins called amyloid-β, tau, and α-synuclein accumulate in the brain and form oligomers. A research group from the Department of Translational Neuroscience, Osaka City University Graduate School of Medicine, had previously shown in a study using mice that the antibiotic rifampicin removes oligomers from the brain and improves cognitive function.

29 Dec 2021

Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene

Using a short, synthetic chain of chemically modified nucleotides engineered in the RNA Therapeutics Institute at UMass Chan Medical School, Robert H. Brown Jr., DPhil, MD, Jonathan Watts, PhD, and colleagues have shown the ability to suppress mutant forms of an ALS gene known as C9ORF72 in a single-patient pilot study.

24 Dec 2021

Scientists determine structure of the molecule associated with ALS for the first time

Scientists have determined for the first time the structure of the molecule associated with amyotrophic lateral sclerosis (ALS) and multiple other neurodegenerative diseases.

9 Dec 2021

Brain injury markers associated with dysregulated immunological responses in COVID-19

Study shows that during hospitalization, patients with COVID-19 demonstrated elevated NfL and GFAP in a severity-dependant manner, as well as evidence of ongoing active brain injury 4 months later.

8 Dec 2021

Leading organizations announce funding for small-scale pilot dementia-related projects

Over the past five years, three leading organizations-;the Alzheimer's Association, Global Brain Health Institute (GBHI), and the UK-based Alzheimer's Society-;have united to address global challenges in dementia through a competitive funding program for emerging leaders in brain health and dementia.

17 Nov 2021

Frontotemporal Dementia News and Research

Researchers discover over 40 new genetic markers for Alzheimer’s disease

Researchers identify motor neuron toxin associated with ALS

Evaluating the Seven Components of Wisdom

Damage to general intelligence brain networks makes it difficult for dementia patients to cope with change

Patients divided over Alzheimer’s drug: Is it a ‘risk I’m willing to take’ or just a ‘magic pill’?

Novel molecular pathway shared by two neurodegenerative disorders discovered

Research reveals why a common genetic variant worsens outcomes for people with ALS and FTD

Being fit can protect older people against mild cognitive impairment

Relationship between SARS-CoV-2 neurotropism and Alzheimer's disease

Tau mapping offers potential treatment targets and biomarkers for dementia and Alzheimer disease

Researchers uncover new findings about the role of tau in neurodegenerative disease

Combination of rifampicin and resveratrol helps stop dementia, finds study

Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene

Scientists determine structure of the molecule associated with ALS for the first time

Brain injury markers associated with dysregulated immunological responses in COVID-19

Leading organizations announce funding for small-scale pilot dementia-related projects

Skin cells could provide better understanding of molecular mechanisms of frontotemporal dementia

Restoring cholesterol levels could be a new therapeutic approach for diseases linked to TDP-43 protein

Global prevalence of dementia estimated to increase to more than 152 million by 2050

Mount Sinai researchers use cerebral organoids to study frontotemporal dementia

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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