Frontotemporal Dementia News and Research

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Researchers unveil a neuroprotective pathway that suppresses ALS

In general, the RAN proteins are more abundant in the cell nucleus, but in patients with Lou Gehrig's disease, they begin to leak out into the cytoplasm, thereby resulting in abnormal concentration differences.

19 Mar 2021

Study demonstrates intricate relationship between Prpf19 and Exoc7 in inherited ataxias

Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph Disease (MJD), describes the most common form of dominantly inherited ataxia in many populations worldwide, including Hong Kong and mainland China.

1 Mar 2021

Gait variability could help diagnose different types of dementia, Alzheimer's disease

Canadian researchers are the first to study how different patterns in the way older adults walk could more accurately diagnose different types of dementia and identify Alzheimer's disease.

16 Feb 2021

Researchers find mechanism underlying plasticity in adult brains

Developing brains constantly sprout new neuronal connections called synapses as they learn and remember. Important connections — the ones that are repeatedly introduced, such as how to avoid danger — are nurtured and reinforced, while connections deemed unnecessary are pruned away.

24 Dec 2020

First UK lockdown during COVID-19 pandemic negatively impacted dementia care

Researchers in the United Kingdom have conducted an extensive survey exploring the impact that lockdown had on people living with low prevalence and young-onset dementias during the first wave of the coronavirus disease 2019 (COVID-19) pandemic.

23 Dec 2020

Study finds surprising link between ALS, FTD and Huntington's disease-associated mutation

A study led by researchers at the National Institutes of Health has made a surprising connection between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two disorders of the nervous system, and the genetic mutation normally understood to cause Huntington's disease.

5 Dec 2020

Study may help to better understand the pathological process involved in brain diseases

A team of researchers at the Case Western Reserve University School of Medicine has taken a major step toward understanding the mechanisms involved in the formation of large clumps of tau protein, a hallmark of Alzheimer's disease and several other neurodegenerative disorders.

1 Dec 2020

Experimental drug can reverse age-related memory decline in mice

Just a few doses of an experimental drug can reverse age-related declines in memory and mental flexibility in mice, according to a new study by UC San Francisco scientists.

1 Dec 2020

Research explores links between Alzheimer's and Parkinson′s to COVID-19

In a recent medRxiv* preprint paper, Dr. L. Miguel Martins and colleagues from the University of Cambridge investigate the links between neurodegeneration and COVID-19.

9 Nov 2020

Research projects receive BTCA grants to develop novel drugs for various diseases

Five research projects with exceptional promise to deliver new life-changing and health-altering therapies have received the inaugural Blavatnik Therapeutics Challenge Awards (BTCA) at Harvard Medical School.

30 Oct 2020

New technique can detect TDP-43 protein in patients with ALS and frontotemporal dementia

A test to diagnose two very serious diseases such as ALS and FTD when the pathologies have not yet appeared, thereby providing doctors and patients with essential information tools to tackle them early and develop new treatments.

27 Oct 2020

Mayo clinic researchers develop a potential test for Machado-Joseph disease

Mayo Clinic researchers, along with national and global collaborators, have developed a potential test for Machado-Joseph disease, or spinocerebellar ataxia type 3 (SCA3) ? a disease that has no cure.

22 Oct 2020

Drug for liver cirrhosis shows potential to treat dementia and motor neuron disease

A drug used to treat cirrhosis of the liver may be an effective treatment for a form of Dementia and motorneuron disease, scientists have discovered.

14 Sep 2020

Investigational drug may reduce protein buildup and neurological decline linked to ALS, FTD

An investigational drug that targets an instigator of the TDP-43 protein, a well-known hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), may reduce the protein's buildup and neurological decline associated with these disorders, suggests a pre-clinical study from researchers at Penn Medicine and Mayo Clinic.

8 Sep 2020

Inhibiting STING activation could be new therapeutic strategy to treat ALS and FTD

Alberto Yáñez Boyer, Ramón y Cajal researcher at BIOTECMED (Interdisciplinary Research Structure in Biotechnology and Biomedicine) and the Department of Microbiology and Ecology at the University of Valencia (UV), participates in a study on the C9orf72 gene and its mutations in the immune system.

28 Aug 2020

New criteria to differentiate between frontotemporal dementia and LATE disease

Working with their colleagues at the University of Pennsylvania, researchers at the University of Kentucky have found that they can differentiate between subtypes of dementia inducing brain disease.

24 Aug 2020

New book series advances the development of pharmaceutical agents for treating neurological, CNS disorders

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders.

21 Aug 2020

Frontotemporal Dementia News and Research

Researchers unveil a neuroprotective pathway that suppresses ALS

Study demonstrates intricate relationship between Prpf19 and Exoc7 in inherited ataxias

Gait variability could help diagnose different types of dementia, Alzheimer's disease

Researchers find mechanism underlying plasticity in adult brains

First UK lockdown during COVID-19 pandemic negatively impacted dementia care

Study finds surprising link between ALS, FTD and Huntington's disease-associated mutation

Study may help to better understand the pathological process involved in brain diseases

Experimental drug can reverse age-related memory decline in mice

Research explores links between Alzheimer's and Parkinson′s to COVID-19

Research projects receive BTCA grants to develop novel drugs for various diseases

New technique can detect TDP-43 protein in patients with ALS and frontotemporal dementia

Mayo clinic researchers develop a potential test for Machado-Joseph disease

Drug for liver cirrhosis shows potential to treat dementia and motor neuron disease

Investigational drug may reduce protein buildup and neurological decline linked to ALS, FTD

Inhibiting STING activation could be new therapeutic strategy to treat ALS and FTD

New criteria to differentiate between frontotemporal dementia and LATE disease

New book series advances the development of pharmaceutical agents for treating neurological, CNS disorders

Study indicates a potential link between Alzheimer's and common brain disorder

Erectile dysfunction drugs lower the accumulation of toxic proteins in zebrafish models

Study examines if Alzheimer's disease and related Dementias affect delirium severity

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