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New insights into rare-among-rare genetic bone disorder

I have been writing about conditions that cause out-of-place bone formation for over 10 years – since the discovery of the gene in 2006 for the rare bone disorder, FOP (fibrodysplasia ossificans progressive). But it was while interviewing geneticist Eileen Shore, PhD last spring about another bone disorder, progressive osseous heteroplasia, or POH, that it really hit me how much more rare POH is compared to FOP.

10 Oct 2017

Alzheimer's gene can protect against and promote neurological damage

Scientists drilling down to the molecular roots of Alzheimer's disease have encountered a good news/bad news scenario. A major player is a gene called TREM2, mutations of which can substantially raise a person's risk of the disease.

9 Oct 2017

Researchers identify molecular clues to understand formation of CCMs

Researchers at University of California San Diego School of Medicine, with national collaborators, have identified a series of molecular clues to understanding the formation of cerebral cavernous malformations (CCMs).

9 Oct 2017

Study reveals advancement in preservation of certain type of medicines in adverse conditions

A recent study by biological engineers at the Johns Hopkins Applied Physics Laboratory in Laurel, Maryland, demonstrated a significant advancement in the preservation of particular types of medicines, known as protein expression systems, for field applications - enabling those medicines to be stored and reconstituted on site in adverse conditions.

9 Oct 2017

UCLA scientists discover potential combination treatment for brain cancer in adults

UCLA scientists have discovered a potential combination treatment for glioblastoma, the deadliest form of brain cancer in adults. The three-year study led by Dr. David Nathanson, a member of UCLA's Jonsson Comprehensive Cancer Center, found that the drug combination tested in mice disrupts and exploits glucose intake, essentially cutting off the tumor's nutrients and energy supply.

9 Oct 2017

New treatment approach makes cancer cells commit suicide while sparing healthy cells

Scientists at Albert Einstein College of Medicine have discovered the first compound that directly makes cancer cells commit suicide while sparing healthy cells.

9 Oct 2017

Researchers discover mutation that amplifies capabilities of tumor-suppressor protein

Cancer researchers have long hailed p53, a tumor-suppressor protein, for its ability to keep unruly cells from forming tumors. But for such a highly studied protein, p53 has hidden its tactics well.

9 Oct 2017

Study sheds new light on underlying genetic causes of congenital heart disease

Approximately one in every 100 babies is born with congenital heart disease (CHD), and CHD remains the leading cause of mortality from birth defects.

9 Oct 2017

Researchers propose LSD1 protein as central player in Alzheimer's and FTD

Removal of a regulatory gene called LSD1 in adult mice induces changes in gene activity that that look unexpectedly like Alzheimer's disease, scientists have discovered.

9 Oct 2017

Study provides insights into non-oncogenic addictions of tumors

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego have shown that tumors can ensure a more reliable nutrient supply by eliminating the p62 protein in surrounding stromal tissue.

9 Oct 2017

Scientists discover how ZATT protein fixes DNA damage caused by cancer treatment

An international team led by scientists at the National Institutes of Health is the first to discover a new way that cells fix an important and dangerous type of DNA damage known as a DNA-protein cross-link.

6 Oct 2017

New topical treatment to combat skin cancer yields promising results in preliminary study

Researchers at the University of São Paulo (USP), in Brazil, are testing a technique in mice that combines low-intensity electric current with a formulation containing nanoencapsulated chemotherapy to treat skin cancer.

6 Oct 2017

Change in epigenetic gene regulation by imprinting can trigger preeclampsia, study shows

Preeclampsia is the most dangerous form of hypertension during a pregnancy and can be fatal for both mother and child. Though it is known to originate in the placenta, the root causes remain largely a mystery.

6 Oct 2017

Study findings provide new insight into inflammatory bowel disease

Findings from a study into Crohn's disease, led by William G. Kerr, Ph.D., of SUNY Upstate Medical University, and his collaborators at the Erasmus Medical Center in the Netherlands, provide the first evidence that patients with debilitating inflammatory bowel disease lack sufficient quantities of a protein that comes from the SHIP1 gene.

6 Oct 2017

Study finds link between high blood lead levels and pre-eclampsia

More than a century since a Brisbane doctor found that lead in paint destroyed children’s lives, new research from Griffith University concludes that it is a major risk factor for pre-eclampsia.

6 Oct 2017

Study reveals link between dietary potassium and vascular calcification

A new study conducted at the University of Alabama at Birmingham suggested that potassium rich food like avocados and bananas might aid in protection against hardening of the arteries, also mentioned as pathogenic vascular calcification.

6 Oct 2017

Foods rich in potassium may help protect against vascular calcification

Bananas and avocados -- foods that are rich in potassium -- may help protect against pathogenic vascular calcification, also known as hardening of the arteries.

5 Oct 2017

Researchers discover new class of fusion genes that affect development of cancer

Cancer researchers at Lund University in Sweden have discovered a new class of fusion genes with properties that affect and may drive the development of cancer.

5 Oct 2017

Powerful new approach could aid design of better drugs with fewer side-effects

A powerful new way of analyzing how drugs interact with molecules in the body could aid the design of better treatments with fewer side-effects.

5 Oct 2017

Gene therapy effectively stabilizes progression of cerebral adrenoleukodystrophy, trial reveals

In a recent clinical trial, a gene therapy to treat cerebral adrenoleukodystrophy (CALD) -- a neurodegenerative disease that typically claims young boys' lives within 10 years of diagnosis -- effectively stabilized the disease's progression in 88 percent of patients, researchers from the Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Massachusetts General Hospital report today.

4 Oct 2017

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G Protein News and Research

New insights into rare-among-rare genetic bone disorder

Alzheimer's gene can protect against and promote neurological damage

Researchers identify molecular clues to understand formation of CCMs

Study reveals advancement in preservation of certain type of medicines in adverse conditions

UCLA scientists discover potential combination treatment for brain cancer in adults

New treatment approach makes cancer cells commit suicide while sparing healthy cells

Researchers discover mutation that amplifies capabilities of tumor-suppressor protein

Study sheds new light on underlying genetic causes of congenital heart disease

Researchers propose LSD1 protein as central player in Alzheimer's and FTD

Study provides insights into non-oncogenic addictions of tumors

Scientists discover how ZATT protein fixes DNA damage caused by cancer treatment

New topical treatment to combat skin cancer yields promising results in preliminary study

Change in epigenetic gene regulation by imprinting can trigger preeclampsia, study shows

Study findings provide new insight into inflammatory bowel disease

Study finds link between high blood lead levels and pre-eclampsia

Study reveals link between dietary potassium and vascular calcification

Foods rich in potassium may help protect against vascular calcification

Researchers discover new class of fusion genes that affect development of cancer

Powerful new approach could aid design of better drugs with fewer side-effects

Gene therapy effectively stabilizes progression of cerebral adrenoleukodystrophy, trial reveals

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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