Gastritis News and Research

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Gastritis is not a single disease, but several different conditions that all have inflammation of the stomach lining. Gastritis can be caused by drinking too much alcohol, prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen, or infection with bacteria such as Helicobacter pylori (H. pylori). Sometimes gastritis develops after major surgery, traumatic injury, burns, or severe infections. Certain diseases, such as pernicious anemia, autoimmune disorders, and chronic bile reflux, can cause gastritis as well.

Study: Disease-causing stomach bacterium shuts down energy production in host cells

Researchers report in a new study that the bacterium Helicobacter pylori - a major contributor to gastritis, ulcers and stomach cancer - resists the body's immune defenses by shutting down energy production within the cells of the stomach lining that serve as a barrier to infection.

31 May 2018

Researchers identify salivary protein that protects the body from traveler's diarrhea

Researchers have identified a protein in saliva (histatin-5) that protects the body from traveler's diarrhea.

8 Mar 2018

Gastric environment permanently changes in the presence of Helicobacter pylori infection

The make-up of the human gut flora is highly individual and extremely diverse. However, when a Helicobacter pylori infection is present, this bacterium displaces all other bacteria in the gastrointestinal tract, leaving only Helicobacter bacteria in the stomach.

23 Jan 2018

When nursing homes push out poor and disabled patients

Anita Willis says the social worker offered her a painful choice: She could either leave the San Jose, Calif., nursing home where she'd spent a month recovering from a stroke — or come up with $336 a day to stay on.

20 Dec 2017

Elevated oral pathogens, less bacterial diversity linked to risk of developing precancerous gastric lesions

Elevated pathogen colonization and a lack of bacterial diversity in the mouth were identified in people with precancerous lesions that could precede stomach cancer, finds a new study led by New York University College of Dentistry and New York University School of Medicine.

28 Nov 2017

Prolonged use of PPIs linked with two-fold increased risk of stomach cancer, study finds

A new study published in the online journal Gut suggested that the prolonged use of proton pump inhibitors (PPIs) that are mainly utilized in treating acid reflux is associated with more than a two-fold increase in the risk of gastric cancer.

1 Nov 2017

Genetic variability of Helicobacter pylori complicates efforts to develop effective vaccine

Helicobacter pylori is a widespread bacterial pathogen that infects the lining of the stomach, where it can cause ulcers and even cancer. As a new study shows, its genetic variability complicates efforts to develop an effective vaccine.

25 Oct 2017

Commonly prescribed gastric acid drug may increase death risk, study shows

Long-term use of a popular class of drug called proton pump inhibitors (PPIS) has been linked to an increased risk of death in a study published in BMJ Open. The findings add to a growing body of evidence linking the use of PPIs to a range of health problems including kidney damage, bone fracture and dementia.

4 Jul 2017

Researchers find low adherence of physicians to H. pylori guidelines

It was long thought that gastric ulcers and other digestive woes were brought about by stress. But in 2005, clinical fellow Barry J. Marshall and pathologist J. Robin Warren were awarded the Nobel Prize in Physiology or Medicine for recognizing the role of Helicobacter pylori in gastritis and peptic ulcer disease.

15 Jun 2017

Neutron analysis helps better understand key bacterial enzyme implicated in stomach cancer

Neutron analysis at the Department of Energy's Oak Ridge National Laboratory is helping researchers better understand a key enzyme found in a bacterium known to cause stomach cancer.

2 Feb 2017

Scientists use pluripotent stem cells to generate human stomach tissues in laboratory

Scientists report in Nature using pluripotent stem cells to generate human stomach tissues in a petri dish that produce acid and digestive enzymes.

5 Jan 2017

Researchers identify promising prospect for new medications to fight against H. pylori

There is a strong suspicion that Helicobacter pylori is linked to the development of stomach cancer. Now an international team of researchers led by Prof. Donald R. Ronning has used neutrons to unlock the secret to the functionality of an important enzyme in the bacterium's metabolism.

21 Dec 2016

Scientists discover new receptors for stomach bacterium Helicobacter pylori

A research group led by Prof. Markus Gerhard of the Technical University of Munich and Assistant Professor Dr. Bernhard B. Singer of the Institute for Anatomy at the Faculty of Medicine of the University of Duisburg-Essen at Essen University Medical Centre has discovered a completely new approach to preventing or treating infections with this bacterium as well as secondary complications.

19 Oct 2016

Researchers discover new approach to preventing H. pylori linked to stomach infections

Researchers have discovered a new approach to preventing or treating a stomach bacterium associated with an increased risk of stomach cancer as well as gastritis and duodenal ulcers.

18 Oct 2016

New device may enable painless, effective diagnosis of Helicobacter in exhaled air

In the future, several illnesses can be quickly and painlessly diagnosed by the optical analysis of isotopes contained in exhaled air. VTT developed its first prototype for this purpose.

16 Jun 2016

Early-life stress may lead to functional dyspepsia in adulthood

Traumatic events early in life can increase levels of norepinephrine—the primary hormone responsible for preparing the body to react to stressful situations—in the gut, increasing the risk of developing chronic indigestion and anxiety during adulthood, a new study in American Journal of Physiology—Gastrointestinal and Liver Physiology reports.

27 May 2016

RedHill Biopharma initiates phase II study of BEKINDA for irritable bowel syndrome

RedHill Biopharma Ltd. (NASDAQ; RDHL) (TASE: RDHL) (“RedHill” or the “Company”), a biopharmaceutical company primarily focused on development and commercialization of late clinical-stage, proprietary, orally-administered, small molecule drugs for inflammatory and gastrointestinal diseases, including cancer, today announced that it has initiated a randomized, double-blind, 2-arm parallel group Phase II clinical study in the U.S. evaluating the safety and efficacy of BEKINDA™ 12 mg in patients with diarrhea-predominant irritable bowel syndrome (IBS-D).

13 Apr 2016

Seaweed extract shows promise in treating H. pylori-related diseases, gastric cancer

A unique seaweed extract shows promise for the treatment of Helicobacter pylori-related diseases and gastric cancer, according to new research undertaken at the University of Western Australia.

28 Nov 2015

MIT researchers devise new system to genetically engineer viruses to combat harmful bacteria

In the hunt for new ways to kill harmful bacteria, scientists have turned to a natural predator: viruses that infect bacteria. By tweaking the genomes of these viruses, known as bacteriophages, researchers hope to customize them to target any type of pathogenic bacteria.

23 Sep 2015

Researchers identify five recurrent fusion genes involved in acute gastritis and cancer

Studying the gastric cancers of 15 Southeast Asian patients, researchers at The Jackson Laboratory, the Genome Institute of Singapore and other institutions identified five recurrent fusion genes, one of which appears to lead to cellular changes involved in acute gastritis and cancer.

10 Jul 2015