Gastroenterology News and Research

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Gastroenterology is the branch of medicine where the digestive system and its disorders are studied.

Data provide key information about epigenetic profiles for gastric cancer

Gastric cancer, one of the most common types of cancer, is associated with high mortality rates. In the last decades, a decrease in the worldwide incidence has been observed with some changes in the therapeutic and diagnostic options.

10 Feb 2010

TI commences Phase IIa clinical trial for its lead molecule in CDH

Trigemina, Inc. (TI), a Mountain View based startup, has begun a Phase IIa clinical trial for its lead molecule in Chronic Daily Headache (CDH) in collaboration with Dr. Egilius Spierings at MedVadis Research Corporation located outside of Boston.

10 Feb 2010

IgM/IgG ratio is useful in diagnosing primary biliary cirrhosis

Previous studies have shown that assessment of immunoglobulin subclasses in plasma cells by immunohistochemistry (IHC) may be useful in the histopathologic evaluation of autoimmune liver diseases. However, further studies are necessary in order to validate the diagnostic utility of IgM and IgG immunohistochemistry in this specific scenario.

10 Feb 2010

Leading researchers discuss latest breakthroughs and best forms of cancer prevention

Eating a balanced diet and preparing your food in the correct way may be your best defense against developing cancer, according to top cancer researchers

9 Feb 2010

Thymosin β4 exhibits potential as new therapeutic agent for liver failure due to chronic HBV infection

REGENERX BIOPHARMACEUTICALS, INC. announced today that researchers have correlated Tβ4 levels with the clinical course of patients with hepatitis B virus-related liver failure. It was reported that serum thymosin β4 levels were significantly lower in patients with chronic hepatitis B infection and that the magnitude of the reduction of thymosin β4 was closely related to the severity of the hepatic injury and to patient death. Since patients with higher Tβ4 levels survived the disease, changes in Tβ4 values could reflect outcome in some liver failure patients.

9 Feb 2010

A novel way to identify color choice in healthy, anxious and depressed individuals

People with anxiety and depression are most likely to use a shade of gray to represent their mental state. Researchers writing in the open access journal BMC Medical Research Methodology describe the development of a color chart, The Manchester Color Wheel, which can be used to study people's preferred pigment in relation to their state of mind.

9 Feb 2010

Study may provide new intervention strategies for esophageal adenocarcinoma

Barrett's epithelium is recognized as a complication of erosive esophagitis and is the pre-malignant condition for adenocarcinoma of the esophagus.

6 Feb 2010

Study suggests environmental factors play a significant role in the etiology of Crohn's disease

Although inflammatory bowel disease (IBD) [comprising mainly Crohn's disease (CD) and ulcerative colitis (UC)] is thought to affect about 150 000 people in the United Kingdom, the prevalence of severe IBD is not known. Mortality following hospitalization for IBD is significant but little has been reported on long-term follow-up.

6 Feb 2010

Endoscopic surveillance could be an appropriate strategy for subepithelial lesions

Although several studies pertaining to the natural history of subepithelial tumors have been published, they have been limited by small sample size and relatively short follow-up. The natural history of subepithelial lesions has not been clearly elucidated, and the appropriate management strategy for small subepithelial tumors is still controversial.

6 Feb 2010

CREON effective in improving CFA and CNA in pediatric patients with EPI due to CF

Solvay Pharmaceuticals, Inc. announced that Phase IIIb data published in the January issue of Clinical Therapeutics confirm that CREON® (pancrelipase) Delayed-Release Capsules significantly improves a key measure of fat absorption in children aged 7-11 years who have exocrine pancreatic insufficiency (EPI) due to cystic fibrosis (CF), EPI is a condition resulting from a deficiency in the production and/or secretion of pancreatic enzymes that are necessary to digest nutrients in food.

5 Feb 2010

Survey finds majority of patients are interested in video recording of colonoscopy procedure

Colonoscopy is operator-dependent and substantial numbers of pre-cancerous polyps are missed during colonoscopy. Colonoscopies are often poorly documented, with only a few still photographs taken of anatomic landmarks and abnormal findings.

5 Feb 2010

NIH panel convened to increase the use and quality of colorectal cancer screening in the U.S.

Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Despite evidence and guidelines supporting the value of screening for this disease, rates of screening for colorectal cancer are consistently lower than those for other types of cancer, particularly breast and cervical.

5 Feb 2010

Researchers evaluate ethical and legal issues of volunteers who participate in endoscopy-based studies

The involvement of healthy volunteers (HV) in clinical and preclinical research, especially in the gastroenterology, has grown dramatically over the past few years. However, many issues of ethical, methodological or even legal concerns have not been systematically studied.

5 Feb 2010

Use of laparoscopic hepatectomy in treating HCC patients achieves complete resection

Conventional hepatectomy is an effective way to treat hepatocellular carcinoma (HCC). However, it is invasive and stressful. Laparoscopic surgery, a kind of minimally invasive surgery, has recently gained considerable advances.

5 Feb 2010

Asuragen enters into research agreements to develop microRNA-based diagnostic test

Asuragen, Inc., a leader in molecular diagnostics and RNA-based pharmacogenomics services, announced today that it has entered into research agreements with The University of Pittsburgh Medical Center, Brigham and Women’s Hospital, the H. Lee Moffitt Cancer Center, Dartmouth’s Hitchcock Medical Center and the University of Sherbrooke to develop a microRNA-based diagnostic test to aid the detection of pancreatic cancer from fine-needle aspirate (FNA) biopsies.

1 Feb 2010

Ipsen reports consolidated group sales of €1,032.8M for 2009

Ipsen reported today its sales for the fourth quarter and full year 2009.

1 Feb 2010

Enhancing the pool of underrepresented minorities may help alleviate healthcare disparities

The number of underrepresented minorities among U.S. medical school faculty remains low, even as the U.S. population becomes increasingly diverse.

29 Jan 2010

Conatus Pharmaceuticals initiates combination trial of CTS-1027 with pegylated interferon and ribavirin for HCV

Conatus Pharmaceuticals Inc. announced today the initiation of a Phase II clinical trial evaluating CTS-1027 in combination with pegylated interferon (Pegasys®) and ribavirin (Copegus®) in refractory HCV patients. Antiviral activity, safety and tolerability of the triple combination will be assessed after up to 48 weeks of therapy.

28 Jan 2010

DNA variations in genes increase risk of developing PI-IBS

Studies of the victims of the Walkerton, Ont. tainted drinking water tragedy have led researchers to discover DNA variations in genes that increase the risk of developing post-infectious irritable bowel syndrome (PI-IBS). The sheer scale of infection and the recording of the health of Walkerton's citizens gave a team of researchers a unique opportunity to study the origin of this disorder.

28 Jan 2010

GI practices team up with NeuIsys to bring advanced imaging technologies for patients

NeuIsys Imaging System Solutions, LLC, a leader in providing state-of-the-art CT and MR imaging systems to physician practices, announced today that three gastroenterology (GI) practices have entered into agreements with NeuIsys to plan, install, and service the recently FDA approved NeuViz 16 Multi-Slice Computed Tomography (CT) System.

28 Jan 2010

Gastroenterology News and Research

Further Reading

Data provide key information about epigenetic profiles for gastric cancer

TI commences Phase IIa clinical trial for its lead molecule in CDH

IgM/IgG ratio is useful in diagnosing primary biliary cirrhosis

Leading researchers discuss latest breakthroughs and best forms of cancer prevention

Thymosin β4 exhibits potential as new therapeutic agent for liver failure due to chronic HBV infection

A novel way to identify color choice in healthy, anxious and depressed individuals

Study may provide new intervention strategies for esophageal adenocarcinoma

Study suggests environmental factors play a significant role in the etiology of Crohn's disease

Endoscopic surveillance could be an appropriate strategy for subepithelial lesions

CREON effective in improving CFA and CNA in pediatric patients with EPI due to CF

Survey finds majority of patients are interested in video recording of colonoscopy procedure

NIH panel convened to increase the use and quality of colorectal cancer screening in the U.S.

Researchers evaluate ethical and legal issues of volunteers who participate in endoscopy-based studies

Use of laparoscopic hepatectomy in treating HCC patients achieves complete resection

Asuragen enters into research agreements to develop microRNA-based diagnostic test

Ipsen reports consolidated group sales of €1,032.8M for 2009

Enhancing the pool of underrepresented minorities may help alleviate healthcare disparities

Conatus Pharmaceuticals initiates combination trial of CTS-1027 with pegylated interferon and ribavirin for HCV

DNA variations in genes increase risk of developing PI-IBS

GI practices team up with NeuIsys to bring advanced imaging technologies for patients

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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