Gene Knockout News and Research

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Scientists uncover four proteins that govern the identity of anaplastic large cell lymphoma

A collaboration between scientists from St. Jude Children's Research Hospital and Dana-Farber Cancer Institute uncovered four proteins that govern the identity of anaplastic large cell lymphoma (ALCL), an aggressive form of cancer.

22 Mar 2024

bit.bio to showcase its ioCRISPR-Ready CellsTM products at the SLAS 2024 international conference and exhibition

bit.bio, the company coding human cells for novel cures, will showcase recent data and important applications of its new portfolio of ioCRISPR-Ready Cells at the Society for Laboratory Automation and Screening (SLAS) conference.

From Society for Laboratory Automation and Screening (SLAS) 5 Feb 2024

New study identifies key role of microRNA-29 in scar-free wound healing

New findings in The American Journal of Pathology, published by Elsevier, report that a class of small RNAs (microRNAs), microRNA-29, can restore normal skin structure rather than producing a wound closure by a connective tissue (scar).

2 Feb 2024

CRISPR revolutionized: New method edits genes directly in the body

Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient.

1 Feb 2024

Prepared for the next virus pandemic: The APPEAL project

In collaboration with 12 partners from 6 countries, MatTek is establishing the Antivirus Pandemic Preparedness EuropeAn pLatform (APPEAL), a European research initiative aimed at enhancing preparedness for future pandemics.

From MatTek Corporation 24 Jan 2024

Recent Advancements in Cell Based Therapy

In this interview, NewsMedical talks to James Brady about cell-based therapy and how the field of genetic engineering transformed.

From MaxCyte, Inc. 11 Oct 2023

Arrayed CRISPR Screening for Revolutionizing Target Discovery

In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Ulrike Kuenzel, Associate Director in the Functional Genomics department at AstraZeneca about the application of arrayed CRISPR screening for target identification and more.

From Society for Laboratory Automation and Screening (SLAS) 27 Sep 2023

NYU Langone doctors complete longest-documented case of pig kidney transplant in human body

After 61 days of observation, NYU Langone Health doctors this month completed the longest-documented case of a genetically engineered pig kidney functioning in a human body.

14 Sep 2023

Review finds correlation between milk oligosaccharides and infant brain development

In a recent article published in Nutrients, researchers investigated the current evidence of the impact of milk oligosaccharides (MOS) on early life neurocognitive and brain development.

30 Aug 2023

Pig kidney xenotransplantation continues to function well after 32 days

Surgeons at NYU Langone Health have transplanted a genetically engineered pig kidney that continues to function well after 32 days in a man declared dead by neurologic criteria and maintained with a beating heart on ventilator support.

16 Aug 2023

New therapy to mitigate fragile X syndrome may be on the horizon

An antisense therapy developed by Joel D. Richter, PhD, Sneha Shah, PhD, and Jonathan K. Watts, PhD, at UMass Chan Medical School and Elizabeth Berry-Kravis, MD, PhD, at RUSH University Medical Center, restores production of the protein FMRP in cell samples taken from patients with fragile X syndrome.

5 Jul 2023

Newly identified enzyme could be a useful tool for creating anticancer drugs

Many of the drugs we use to treat cancer and infectious disease are ⎯ or derive from ⎯ natural products, but it's difficult to know exactly how nature assembles them.

27 Jun 2023

Exploring evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates

Researchers performed high-throughput evolutionary analyses of genes encoding 334 SARS-CoV-2 viral-interacting proteins of modern humans, primates, and bats.

11 Apr 2022

Non-hormonal male contraceptive effectively prevents pregnancy in mice

Women have many choices for birth control, ranging from pills to patches to intrauterine devices, and partly as a result, they bear most of the burden of preventing pregnancy.

24 Mar 2022

NYU Langone Health performs second successful investigational xenotransplantation procedure

Less than two months after the first breakthrough surgery, NYU Langone Health has performed its second successful investigational xenotransplantation procedure using a genetically engineered pig kidney.

13 Dec 2021

A promising new therapeutic target for kidney disease

Despite nearly two million people dying of acute kidney injury every year, and tens of millions more needing treatment, no effective drug treatment for the condition is available.

7 Dec 2021

Study highlights the need for caution while using CRISPR-based gene therapies

A comprehensive study-;conducted by researchers at Sanford Burnham Prebys, the National Cancer Institute (NCI) and other groups-;has shown that gene editing, specifically gene knockout (KO), with CRISPR -Cas9 can favor cells with mutated forms of genes linked to cancer.

11 Nov 2021

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

New findings identify CASP4/11 as detrimental to inflammation and coagulopathy associated with SARS-CoV-2 infection.

28 Sep 2021

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

Fruit fly provides insight into controlling carbs and fat

Incretins are hormones secreted by intestinal cells that regulate pancreatic insulin and glucagon to control sugar metabolism in mammals.

19 Aug 2021