Gene Transfer News and Research

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Gene Transfer is the insertion of genetic material into a cell.

Rising antibiotic resistance prompts shift to ecological research strategies in infection control

The need to enhance research on the interactions between bacterial pathogens and commensals within human microbiomes.

12 Apr 2024

Investigational gene therapy shows promise for rare childhood neurodegenerative disease

An investigational gene therapy for a rare neurodegenerative disease that begins in early childhood, known as giant axonal neuropathy (GAN), was well tolerated and showed signs of therapeutic benefit in a clinical trial led by the National Institutes of Health.

20 Mar 2024

Novel genetic mechanisms of tetracycline resistance in gut bacteria discovered

Antibiotic resistance is a significant and growing medical problem worldwide. Researchers at the Marine Biological Laboratory (MBL) and collaborators have found a novel genetic arrangement that may help a common bacterium in the human gut, Bacteroides fragilis, protect itself from tetracycline, a widely used antibiotic.

1 Mar 2024

Key link discovered between spread of antibiotic resistance genes and drug resistance evolution

Biomedical engineers at Duke University have uncovered a key link between the spread of antibiotic resistance genes and the evolution of resistance to new drugs in certain pathogens.

23 Feb 2024

Ancient DNA reveals syphilis-like disease in pre-Columbian America

Researchers at the Universities of Basel and Zurich have discovered the genetic material of the pathogen Treponema pallidum in the bones of people who died in Brazil 2,000 years ago.

24 Jan 2024

€1.6M project aims to crack the code of degradation-resistant tumors

An international research project on the subject of "Understanding and targeting degradation-resistant tumors" has been granted funding of 1.655 million euros through the German-Israeli Project Cooperation (DIP) program.

11 Jan 2024

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

Researchers developed an RNA-based switch, the pA regulator system, to control gene expression in mammalian cells by modulating synthetic polyA signal cleavage, offering a novel approach for gene therapy applications.

4 Jan 2024

Liver trigger holds the key to boosting gene therapy success

Indiana University School of Medicine researchers have uncovered vital insights regarding a liver trigger that blocks an undesired immune response from gene therapy, surprisingly resulting in the activation of specific immune cells, despite the liver's typical role in suppressing immune responses.

7 Dec 2023

Machine learning unlocks secrets of antimicrobial resistance, identifying over 900 key genes

Researchers employed advanced techniques like gene annotation, pangenomics, and machine learning to identify over 900 genes responsible for antimicrobial resistance in 12 bacterial species, outperforming traditional identification methods. This breakthrough approach offers new insights into the genetic basis of resistance, potentially guiding the development of more effective antibiotics

27 Nov 2023

Genetics and sedimentology combined to refine cyanobacteria biomarker diagnostics

Cyanobacteria are a key species in Earth's history, as they introduced atmospheric oxygen for the first time. The analysis of their evolution therefore provides important insights into the formation of modern aerobic ecosystems.

27 Oct 2023

Gene therapy breakthrough: Scientists develop method to deliver larger genes to target cells

Gene therapy currently represents the most promising approach for the treatment of hereditary diseases. Yet despite significant breakthroughs in recent years, there are still a number of hurdles that hinder the wider application of gene therapies.

24 Oct 2023

The outcome of invasive S. pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity

The interplay between human STING genotype and bacterial NADase activity.

22 Aug 2023

Understanding the mechanisms behind rising antifungal drug resistance

In a recent study, researchers addressed the issue of the rise of antifungal drugs-resistant infections and the advent of multidrug-resistant fungal pathogens.

19 Jul 2023

The hidden factors of resistance: how pathogen diversity drives antibiotic response

Researchers aimed to understand the role of within-host microbial diversity on antimicrobial resistance.

14 Jul 2023

Surprising ancestry of caterpillar venom could be key to delivery of lifesaving drugs

Researchers at The University of Queensland have discovered the venom of a notorious caterpillar has a surprising ancestry and could be key to the delivery of lifesaving drugs.

10 Jul 2023

The relationship between the burden of antibiotic resistance in humans and community access to drinking water and sanitation

Researchers determined the link between improved access to sanitation and better water quality and the human intestines' antibiotic resistance gene frequency.

5 Jul 2023

Spanish researchers develop new immunotherapy combination for liver cancer

Spanish researchers at Cima University of Navarra have developed a new immunotherapy combination that improves efficacy in animal models of hepatocellular carcinoma. This is a proof of concept that lays the foundations for the application of this treatment in patients with the most common liver cancer.

1 Jul 2023

First programmable RNA-guided system found in eukaryotes

A team of researchers led by Feng Zhang at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has uncovered the first programmable RNA-guided system in eukaryotes -; organisms that include fungi, plants, and animals.

28 Jun 2023

Targeting Phage Therapy 2023 showcased the progress and possibilities of phage therapy in future

The 6th World Congress on Targeting Phage Therapy 2023 that was held on June 1-2 in Paris, and gathered more than 150 attendees from 30+ different countries. Targeting Phage Therapy 2023 included more than 71 presentations between major talks, short orals, and posters.

20 Jun 2023

Researchers may have identified a molecular cause for memory changes in early childhood

How do our brains become capable of creating specific memories? In one of the first preclinical studies to examine memory development in youth, a research team at The Hospital for Sick Children (SickKids) may have identified a molecular cause for memory changes in early childhood.

16 May 2023