Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Researchers use new analysis method to determine genes that result in cell death

Lethal and rescuer genes are defined as genes that when inactivated result in cell death or enhanced cell growth, respectively. The ability to identify these genes in large-scale automated screening campaigns could lead to the discovery of valuable new drug targets.

17 May 2013

Study reveals how and why developmental genes often take inputs from 2 independent sources

Albert Erives, associate professor in the University of Iowa Department of Biology, and his graduate student, Justin Crocker, currently a postdoctoral researcher at the Howard Hughes Medical Institute Janelia Farm Research Campus, have conducted a study that reveals important and useful insights into how and why developmental genes often take inputs from two independent "morphogen concentration gradients."

16 May 2013

Bacteria form biofilm to protect against immune system

Bacteria are life forms, which, like all other life forms, struggle for the best living conditions for themselves. Therefore they will try to avoid getting attacked by the human immune system, and therefore they have developed various ways to protect themselves from the human immune system.

15 May 2013

Study provides evidence of altered circadian gene rhythms in brain tissue of people with depression

UC Irvine Health researchers have helped discover that genes controlling circadian clock rhythms are profoundly altered in the brains of people with severe depression.

14 May 2013

New research shows that spontaneous mutations contribute to congenital heart disease

Every year, thousands of babies are born with severely malformed hearts, disorders known collectively as congenital heart disease. Many of these defects can be repaired though surgery, but researchers don't understand what causes them or how to prevent them. New research shows that about 10 percent of these defects are caused by genetic mutations that are absent in the parents of affected children.

13 May 2013

Findings to help researchers study causes of congenital heart disease in future

Findings from the first large-scale sequencing analysis of congenital heart disease bring us closer to understanding this most common type of birth defect. The analysis found that spontaneous, or de novo, mutations affect a specific biological pathway that is critical to aspects of human development, including the brain and heart.

13 May 2013

Research could help battle stubborn bacterial infections that do not respond to antibiotics

Bacteria on a surface wander around and often organize into highly resilient communities known as biofilms. It turns out that they organize in a rich-get-richer pattern similar to many economies, according to a new study by researchers at UCLA, Northwestern University and the University of Washington.

10 May 2013

Modifications in key epigenetic markers influence human embryonic stem cells

Scientists have long known that control mechanisms known collectively as "epigenetics" play a critical role in human development, but they did not know precisely how alterations in this extra layer of biochemical instructions in DNA contribute to development.

10 May 2013

New research from Wake Forest Baptist looks at gene expression profiling in breast cancer

Predicting outcomes for cancer patients based on tumor-immune system interactions is an emerging clinical approach, and new research from Wake Forest Baptist Medical Center is advancing the field when it comes to the most deadly types of breast cancer.

10 May 2013

Drug resistant brain tumors: an interview with Prof. Mischel, Ludwig Institute for Cancer Research and Prof. Bensinger, University of California

In cancer, mutations in proteins that control cell growth are common, leading to unrestrained cellular proliferation and tumor formation.

9 May 2013

Exosome Diagnostics' urine exosome technology accurately predicts outcome of prostate biopsy

Exosome Diagnostics, a leading developer of biofluid-based molecular diagnostic products for use in personalized medicine research and clinical diagnostics, today announced the presentation of data at the American Urological Association Annual Meeting in San Diego demonstrating the performance of urine exosome technology in accurately predicting the outcome of a prostate biopsy.

9 May 2013

Patients with ASPS appear to benefit from anti-cancer drug, cediranib

Patients with advanced alveolar soft part sarcoma (ASPS), a rare cancer, achieved some control of their disease using an experimental anti-cancer drug called cediranib.

8 May 2013

Scientists identify TR4 protein that drives the formation of pituitary tumors in Cushing's disease

Scientists at the Salk Institute for Biological Studies have identified a protein that drives the formation of pituitary tumors in Cushing's disease, a development that may give clinicians a therapeutic target to treat this potentially life-threatening disorder.

8 May 2013

Idera to present data from Phase 2 trial of IMO-3100 in patients with psoriasis at IID 2013

Idera Pharmaceuticals today announced presentation of data from its randomized, double-blind, placebo-controlled Phase 2 trial that showed improvements from baseline of up to 90% in Psoriasis Area Severity Index scores in patients with moderate to severe plaque psoriasis following four weeks of treatment with the Toll-like Receptor antagonist IMO-3100.

8 May 2013

Study shows turning up few microRNAs may offer much anti-breast-cancer activity

A University of Colorado Cancer Center study recently published in the journal Cell Death & Disease shows that turning up a few microRNAs a little may offer as much anti-breast-cancer activity as turning up one microRNA a lot - and without the unwanted side effects.

8 May 2013

Study offers new hope to patients suffering from laminopathies

Laminopathies are hereditary diseases that affect mainly the muscle tissue. These diseases include for example Emery-Dreifuss Muscular dystrophy, dilated cardiomyopathy, limb-girdle muscular dystrophy and Hutchison-Gilford progeria syndrome.

7 May 2013

Study: Gene mutations are associated with severe form of nearsightedness

People have long taken for granted that glasses and contact lenses improve vision for nearsightedness, but the genetic factors behind the common condition have remained blurry. Now researchers at Duke Medicine are closer to clearing this up.

3 May 2013

Study results may help introduce better preoperative treatment for breast cancer

Breast cancers contain many different cell types with different patterns of gene expression, but a new study provides reassurance that this variability should not be a barrier to using gene expression tests to help tailor cancer treatments to individual patients.

3 May 2013

New technology to study interactions between metal elements, molecules in living organisms

Metal elements and molecules interact in the body but visualizing them together has always been a challenge. Researchers from the RIKEN Center for Life Science Technologies in Japan have developed a new molecular imaging technology that enables them to visualize bio-metals and bio-molecules simultaneously in a live mouse.

3 May 2013

Measurement variation influences gene expression profiles of breast cancer

An important new study has revealed the clearest picture yet of precisely how much measurement variation influences gene expression profiles of breast cancer.

3 May 2013

Gene Expression News and Research

Further Reading

Researchers use new analysis method to determine genes that result in cell death

Study reveals how and why developmental genes often take inputs from 2 independent sources

Bacteria form biofilm to protect against immune system

Study provides evidence of altered circadian gene rhythms in brain tissue of people with depression

New research shows that spontaneous mutations contribute to congenital heart disease

Findings to help researchers study causes of congenital heart disease in future

Research could help battle stubborn bacterial infections that do not respond to antibiotics

Modifications in key epigenetic markers influence human embryonic stem cells

New research from Wake Forest Baptist looks at gene expression profiling in breast cancer

Drug resistant brain tumors: an interview with Prof. Mischel, Ludwig Institute for Cancer Research and Prof. Bensinger, University of California

Exosome Diagnostics' urine exosome technology accurately predicts outcome of prostate biopsy

Patients with ASPS appear to benefit from anti-cancer drug, cediranib

Scientists identify TR4 protein that drives the formation of pituitary tumors in Cushing's disease

Idera to present data from Phase 2 trial of IMO-3100 in patients with psoriasis at IID 2013

Study shows turning up few microRNAs may offer much anti-breast-cancer activity

Study offers new hope to patients suffering from laminopathies

Study: Gene mutations are associated with severe form of nearsightedness

Study results may help introduce better preoperative treatment for breast cancer

New technology to study interactions between metal elements, molecules in living organisms

Measurement variation influences gene expression profiles of breast cancer

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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