Gene Silencing News and Research

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Targeted nanoparticles offer promising techniques for cancer treatment

Researchers in the laboratory of Mark E. Davis at the California Institute of Technology have been using small interfering RNA (siRNA), sometimes known as silencing RNA, to "silence" specific genes that are implicated in certain malignancies.

22 May 2007

Important new gene-silencing mechanism

Genes provide the instructions used by the individual cells to produce the many different proteins that make up the body.

17 May 2007

New vitamin extends lifespan in yeast cells

Imagine taking a vitamin for longevity! Not yet, but a Dartmouth discovery that a cousin of niacin prolongs lifespan in yeast brings the tantalizing possibility a step closer.

4 May 2007

New understanding of how histone and DNA methylation communicate

In the May 15th issue of G&D, Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes.

30 Apr 2007

Sigma-Aldrich grants Pfizer license to use ddRNAi

Sigma-Aldrich has announced that it has granted Pfizer a worldwide non-exclusive research license to utilize DNA-directed RNAi (ddRNAi) technology. Applications of the ddRNAi technology for research activities have been licensed exclusively by Sigma- Aldrich from Benitec Limited of Australia.

3 Jan 2007

Federally approved human embryonic stems inferior to those donated for research

Neural stem cells grown from one of the federally approved human embryonic stem cell lines proved to be inferior to neural stem cells derived from fetal tissue donated for research, a UCLA study has found.

4 Aug 2006

Effective gene suppression using small interfering RNA in hard-to-transfect human T cells

A technical advance in laboratory techniques may provide biology researchers broader access to RNA interference, a process of blocking the activity of targeted genes. RNA interference has recently emerged as an important tool in studying how genes function in normal biological processes and in disease.

9 May 2006

Gene silencing protein discovered

A team of researchers, including biologists at Washington University in St. Louis, has discovered the key role one protein plays in a major turn-off -in this case, the turning off of thousands of nearly identical genes in a hybrid plant.

8 May 2006

Allergy-free soybeans

Researchers have isolated two Chinese soybean lines that grow without the primary protein linked to soy allergies in children and adults.

8 May 2006

Novel protein JHDM2A offers new look at male hormone regulation

For the second time in less than a year, University of North Carolina at Chapel Hill scientists have purified a novel protein and have shown it can alter gene activity by reversing a molecular modification previously thought permanent.

8 May 2006

Cancer found grow by switching off DNA - may lead to new generation treatments

Cancer researchers have formulated a new concept for how cancer cells can escape normal growth controls by turning off DNA. These findings may have far-reaching implications for the new generation of cancer therapies.

25 Apr 2006

Important new global mechanism for gene repression

Most of the time in most cells of the body, the great majority of genes are silenced, locked away within the compacted but orderly material that makes up chromosomes.

18 Apr 2006

Researchers identify the role of a protein in hemoglobin gene silencing

Virginia Commonwealth University Massey Cancer Center researchers have identified the role of a protein in hemoglobin gene silencing that may one day be a potential target for the treatment of genetic blood disorders like sickle-cell anemia and beta-thalassemia on the molecular level.

11 Apr 2006

New tool for genetic research

In an article appearing online today in the journal Nature Methods, researchers at the EPFL (Ecole Polytechnique Fidirale de Lausanne) unveil a powerful new tool that will facilitate genetic research and open up new avenues for the clinical treatment of genetic disease.

23 Jan 2006

World's deadliest malaria parasite cloaking gene revealed

The world's deadliest malaria parasite, Plasmodium falciparum, sneaks past the human immune system with the help of a wardrobe of invisibility cloaks. If a person's immune cells learn to recognize one of the parasite's many camouflage proteins, the surviving invaders can swap disguises and slip away again to cause more damage. Malaria kills an estimated 2.7 million people annually worldwide, 75 percent of them children in Africa.

29 Dec 2005

New cell findings have implications for cancer, immune disorders

It all started 5 years ago when a University of Calgary neuroscientist sent blood from a patient with a neurological disorder to the laboratory of Dr. Marvin Fritzler, professor of medicine / biochemistry & molecular biology at the University of Calgary Faculty of Medicine.

15 Dec 2005

Gene silencing and microRNA discovery

One of the body's primary strategies for regulating its genome is a kind of targeted gene silencing orchestrated by small molecules called microRNAs, or miRNAs.

7 Nov 2005

CSIRO's RNAi 'gene silencing' patents strengthened

The patent landscape for RNAi 'gene silencing' - including CSIRO's hairpin RNAi technology - has been significantly clarified following the resolution of several opposition and re-examination cases in Australia.

26 Oct 2005

Significant new breakthroughs in understanding how the genes in mammals are controlled

An international consortium of genome research institutes and investigators, including Jackson Laboratory Staff Scientists Carol J. Bult, Ph.D., and Martin Ringwald, Ph.D., has reported significant new breakthroughs in understanding how the genes in mammals are controlled.

6 Sep 2005

Patent for determining gene function quickly with Hellsgate

A CSIRO innovation for determining gene function quickly and with virtually 100 per cent efficiency has been granted a US patent clarifying its leadership position in the international gene silencing arena.

6 Sep 2005