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Breakthrough research offers hope for improved treatment of chronic wounds

Novel research, presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2024, has identified key molecular targets that could significantly enhance the healing of both acute and chronic wounds.

25 Sep 2024

H5N1 bird flu is mutating fast and jumping to mammals - could the next pandemic be here?

Researchers reveal how H5N1 viruses rapidly adapted to mammals through genetic reassortment and specific mutations, raising concerns over potential pandemic risks. Evidence from mink, marine mammals, and dairy cattle shows mammal-to-mammal transmission.

25 Sep 2024

New deep learning algorithm predicts effects of rare genetic variants

Whether we are predisposed to particular diseases depends to a large extent on the countless variants in our genome.

25 Sep 2024

Researchers gain new understanding of how immune cells respond to heat during fever

The study reveals that moderate fever enhances CD4 T cell activity while reducing regulatory T cell suppression, highlighting temperature's immune effects.

25 Sep 2024

Combining treatments to boost tumor response in lung cancer

Researchers at the Francis Crick Institute, in collaboration with Revolution Medicines, have tested a combination of treatments in mice with lung cancer and shown that these allow immunotherapies to target non-responsive tumors.

25 Sep 2024

Night-time aircraft noise linked to sleep disturbance

Noise from aircraft at night is linked with disturbed sleep quality and sleep-wake cycle, a new study using movement trackers has shown.

25 Sep 2024

New FDA award fuels research into autosomal dominant tubulointerstitial kidney disease

Critical Path Institute (C-Path) is thrilled to announce its Polycystic Kidney Disease Outcomes Consortium (PKDOC) has been awarded an Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) focused Broad Agency Announcement (BAA) contract from the U.S. Food and Drug Administration (FDA).

24 Sep 2024

Study uncovers decision-making impairments linked to Parkinson's drug

Parkinson's disease (PD), also known simply as Parkinson's, is a disorder of the nervous system that affects millions of people worldwide.

24 Sep 2024

Innovative HiTIP-seq method advances epigenetic research in pediatric brain tumors

Diffuse midline glioma (DMG) is a highly aggressive and fatal pediatric high-grade glioma that primarily affects critical regions of the central nervous system, such as the pons, thalamus, and spinal cord.

24 Sep 2024

"Not just a phase": Fussy eating is mainly influenced by genes and is a stable trait

This research highlights the genetic basis of food fussiness in children, with over 70% of influence from genes, informing strategies for dietary interventions.

24 Sep 2024

Microbial biomarkers identified in lupus and IBD offer pathways for targeted therapies

Research connects gut microbiota to lupus and IBD, uncovering microbial markers and pathways that could inform targeted therapies for autoimmune disorders.

24 Sep 2024

Known genes account for most undiagnosed cases of developmental disorders

Scientists have conducted the largest and most diverse study to date on how recessive genetic changes contribute to developmental disorders. They found that most undiagnosed cases that are due to recessive causes are linked to genes we already know about, and suggest a shift in research focus could improve diagnosis rates.

24 Sep 2024

Groundbreaking project seeks to illuminate the complexities of Parkinson's

Launching today, Landmark is a groundbreaking three-year research programme that aims to understand Parkinson’s in unprecedented detail. The project brings together Parkinson’s UK, Imperial College London, GSK, Novartis, Roche and UCB for the first time, and has been made possible by a founding gift of £4 million from the Gatsby charitable foundation.

24 Sep 2024

New CRISPR model offers deeper insight into prostate cancer metastasis

A new preclinical model using CRISPR, an advanced technology that allows scientists to cut and edit genes, has given Weill Cornell Medicine researchers and their colleagues a deeper insight into how prostate cancer spreads or metastasizes.

23 Sep 2024

The role of CRISPR-Cas9 in combating mosquito-borne diseases

Announcing a new article publication for Zoonoses journal. As global warming increases, mosquito activity areas are expanding, alongside changes in the natural environment and the misuse of insecticides, thus further increasing mosquito resistance and exposing the world to an elevated risk of mosquito-borne diseases.

23 Sep 2024

Enhanced TnpB protein offers new possibilities for gene editing

CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known "gene scissor" but is much smaller and thus easier to transport into cells.

23 Sep 2024

Key genetic factors linked to severe cholera symptoms discovered

Experts have used a cutting-edge computational approach to discover the genetic factors that make the bacteria behind cholera so dangerous - which could be key to preventing this deadly disease.

23 Sep 2024

Study uncovers novel genetic variant associated with intellectual disability

Researchers at the Icahn School of Medicine at Mount Sinai have published a pivotal study in Nature Genetics (DOI: 10.1038/s41588-024-01917-1) that sheds light on a novel genetic variant associated with intellectual capacities and educational outcomes.

23 Sep 2024

Calcium channel blockers show potential to restore cerebral blood flow in Alzheimer's disease

Targeting calcium channels in pericytes may improve blood flow in Alzheimer's disease, addressing early vascular dysfunction linked to cognitive deficits.

23 Sep 2024

Mediterranean diet during pregnancy reduces childhood obesity risk

Following a Mediterranean diet during pregnancy reduced the likelihood of children being overweight or obese by age two, with no cases of obesity in the diet group. The diet’s influence on the leptin gene may explain these effects.

22 Sep 2024