Genetic News and Research

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Cleavage stage embryo with aneuploidy can undergo genetic normalisation process

Professor William G. Kearns told the annual meeting of the European Society of Human Reproduction and Embryology that a three-day-old embryo with an incorrect number of chromosomes was capable of undergoing "a dynamic process of genetic normalisation" so that by day five, when it had developed to the blastocyst stage, it had become euploid, with the correct number of chromosomes.

5 Jul 2011

LCMC finds 9.6% of lung cancer patients with ALK rearrangement

ALK rearrangement has been found in 9.6% of lung cancer patients tested in the Lung Cancer Mutation Consortium, and MET amplification in another 4.1%, reflecting how many patients might benefit from targeted therapies such as crizotinib, according to research presented at the 14th World Conference on Lung Cancer in Amsterdam, hosted by the International Association for the Study of Lung Cancer.

5 Jul 2011

Autism Speaks announces significant findings from largest study of twins with ASD

Autism Speaks, the world's largest autism science and advocacy organization, joined in announcing significant findings from the largest known study of twins with autism spectrum disorder.

5 Jul 2011

Zebrafish study uncovers new information about hepatocellular carcinoma

Hepatocellular carcinoma, the most common type of liver cancer, is a leading cause of cancer-related deaths worldwide. Although there are several treatment options available, they are largely unsuccessful because the disease is so poorly understood. Clinical studies of patients with HCC, combined with studies using mice and other animal models, have provided some clues, but many questions about how to diagnose and treat this deadly form of cancer remain.

5 Jul 2011

Fruit flies with poor posture help scientists understand human intellectual disability

Clumsy fruit flies with poor posture are helping an international team of scientists understand inherited intellectual disability in humans - and vice versa.

5 Jul 2011

Shared environment influences susceptibility to autism more than previously thought

The largest and most rigorous twin study of its kind to date has found that shared environment influences susceptibility to autism more than previously thought.

5 Jul 2011

Amyloid peptide Aβ43 may serve as biomarker for diagnosis of Alzheimer's

Researchers at the RIKEN Brain Science Institute (BSI) and their collaborators have shed light on the function of a little-studied amyloid peptide in promoting Alzheimer's disease.

4 Jul 2011

New insight into oocyte chromosome abnormalities

Ovarian stimulation undertaken by women of advanced maternal age receiving fertility treatment may be disrupting the normal pattern of meiosis - a critical process of chromosome duplication followed by two specialised cell divisions in the production of oocytes and sperm - and leading to abnormalities of chromosome copy numbers that result in IVF failure, pregnancy loss or, more rarely, the birth of affected children with conditions such as Down's syndrome, which is caused by the inheritance of three copies of chromosome 21.

4 Jul 2011

Simple blood test for melanoma-inhibitory activity could detect neurofibromas

Neurofibromatosis (NF1) is a genetic condition which affects one in every 3,000 people. The severity of symptoms can range from benign 'café au lait' patches on the skin, through small tumors under the skin and deep plexiform neurofibromas, to malignant tumors of the nerve sheath.

4 Jul 2011

Scientists use statistical approach to assess order of genetic abnormalities in cancers

Zeroing in on the early cell mutations that enable a cancer to grow is one of the best ways to find a personalized therapy to stop it. Scientists were able to use a statistical approach for the first time to map out the order in which these abnormalities form to analyze the pattern of DNA changes in advanced skin and ovarian tumors.

2 Jul 2011

Medical practitioners can help reduce breast cancer deaths in African-American women

Wayne State University researchers believe medical practitioners can help reduce the number of breast cancer deaths among low-income African-American women by more effectively educating their patients about the importance of mammography screening.

2 Jul 2011

European joint project to develop novel HCV vaccine based on nanotechnology

HCVAX is a European joint project that reaches out to develop a vaccine against hepatitis C based on nanotechnology. The German Helmholtz Centre for Infection Research in Braunschweig and its department "Vaccinology and Applied Microbiology" is now a part of the transnational consortium with researchers from Germany, France and Switzerland.

2 Jul 2011

Transnational research group examines how viruses evade immune system

Understanding the tricks and survival strategies of viruses to effectively combat them: That is the goal of the virtual institute VISTRIE that received its funding commitment today.

2 Jul 2011

STSI receives NIH grant to conduct heart-based research

Researchers looking to find a root cause for heart attacks and coronary artery disease will soon begin using a novel investigative approach that borders on science fiction as they work toward the holy grail of American medicine: preventing the nation's No. 1 killer.

2 Jul 2011

Genetically engineered pigs may help overcome donor organ shortage

A sizzling genetic discovery by Chinese scientists may one day allow pig tissue to be transplanted successfully into humans. Their research presented in the Journal of Leukocyte Biology (http://www.jleukbio.org) represents a major step forward toward filling the shortage of vital organs for human transplantation.

1 Jul 2011

GWAS identifies 15 gene variants responsible for diversity of white blood cell counts

A trio of large-scale genome-wide association studies, or GWAS, have identified more than 15 gene variants responsible for the diversity of white blood cell counts among whites, African-Americans, and Japanese.

1 Jul 2011

The Max Cure Foundation, SWCRF partner to fund pediatric cancer research

The Max Cure Foundation and the Samuel Waxman Cancer Research Foundation have partnered to establish a fund in pediatric cancer research. With that goal in mind, the two Foundations are proud to announce the award of $100,000 to Erwin G. Van Meir, Ph.D., of Emory University School of Medicine in Atlanta.

1 Jul 2011