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FDA can promote personalized medicine by identying gaps in laboratory operations: ACLA

The Food and Drug Administration can promote progress toward personalized medicine by approaching the oversight of laboratory developed tests (LDTs) in a focused, flexible, and balanced way according to the American Clinical Laboratory Association (ACLA). ACLA, which represents the nation's leading clinical laboratories, says that the factors supporting this approach include the growing role that such tests play in clinical decision making, especially in the area of new advanced diagnostics that derive from the mapping of the human genome and help fulfill the promise of personalized medicine.

17 Jul 2010

Research findings may help identify human TOR kinase inhibitors

A parasite estimated to afflict as many as 12 million people worldwide relies on a family of genes that should make it vulnerable to compounds developed to treat cancer and other disorders, researchers at Washington University School of Medicine in St. Louis have found.

17 Jul 2010

Study results to help researchers better understand cancer genetics, improve treatment regimens

The largest study to correlate genetics with response to cancer drugs releases its first results today. The researchers behind the study, based at Massachusetts General Hospital Cancer Center and the Wellcome Trust Sanger Institute, describe in this initial dataset the responses of 350 cancer samples to 18 anticancer therapeutics.

16 Jul 2010

DNA copying error in autism sufferers discovered

Rubicon winner Dalila Pinto discovered a copying error in the DNA of trial subjects who suffered from autism or a similar condition. Some segments of their DNA were copied either once too often or missed out of the copying process. This is a highly promising result from the world's largest investigation into autism. The top journal Nature placed the results online on 9 June.

16 Jul 2010

Eurofins MWG Operon, Genomatix Software offer joint services to develop complete human exome array

Eurofins MWG Operon, an expert in next generation sequencing and Certified Service Provider for Roche NimbleGen sequence capture, together with Genomatix Software GmbH, a leading company in complex analysis and interpretation of such NGS data, announce that they have developed a complete human exome array, based on Roche NimbleGen sequence capture technology.

15 Jul 2010

Key protein in insulin signaling pathway adds insights into development, aging

What makes a bee grow up to be a queen? Scientists have long pondered this mystery. Now, researchers in the School of Life Sciences at Arizona State University have fit a new piece into the puzzle of bee development. Their work not only adds to understanding about bees, but also adds insights into our own development and aging.

15 Jul 2010

Keck School of Medicine receives grant for research on biomarker impact on breast cancer screening

Researchers at the Keck School of Medicine of the University of Southern California (USC) will test whether a set of blood-based biomarkers can assist mammography in the early detection of breast cancer with a $180,000 grant announced today from Susan G. Komen for the Cure®. The grant will fund research into whether specific biomarkers, or minute substances in the blood, can effectively distinguish breast cancer patients from their healthy counterparts and whether an inexpensive, less invasive screening strategy can be developed based on this approach.

15 Jul 2010

NIH awards $38.2M grant to Georgetown-Howard Universities Center for Clinical and Translational Science

In support of a critical partnership between Georgetown University Medical Center and Howard University, the National Institutes of Health (NIH) has awarded a $38.2 million Clinical and Translational Sciences Award to aid the universities' effort to transform health care and preventive practices in communities through medical discoveries made in laboratories and clinical settings.

15 Jul 2010

Samsung Medical Center, Pfizer form research partnership

Samsung Medical Center and the world's leading bio-pharmaceutical company Pfizer Inc. announced that they have formed a research partnership to jointly analyze tumors from Korean patients to generate gene expression profiles and that may ultimately direct therapies and enhance clinical outcomes in the patients with liver cancer.

14 Jul 2010

BioInvent reports net revenues of SEK 63.1M for January - June 2010 period

BioInvent reached an important milestone when the results of a phase II trial of TB-402 following orthopaedic surgery, were reported in May. The data showed that TB-402 is statistically better at preventing thrombosis than enoxaparin, the current standard treatment. Supported by these good results, BioInvent and the company's partner, ThromboGenics, will now prioritise securing a development partner for the programme to ensure that the necessary resources is in place to take the product candidate to the market.

14 Jul 2010

Maven Semantic releases updates to Biotechnology research database

Maven Semantic (http://www.mavensemantic.com) announces updates to their Biotechnology research database.

14 Jul 2010

Susceptibility to Behcet's disease associated with genes involved in body's immune response

Researchers with the National Institutes of Health have found susceptibility to Behcet's disease, a painful, inflammatory condition, to be associated with genes involved in the body's immune response.

14 Jul 2010

Gene therapy represents safe alternative to current cures for blood disorder β-thalassemia

Italian scientists pioneering a new gene transfer treatment for the blood disorder β-thalassemia have successfully completed preclinical trials, claiming they can correct the lack of beta-globin (β-globin) in patients' blood cells which causes the disease. The research, published in EMBO Molecular Medicine, reveals how gene therapy may represent a safe alternative to current cures that are limited to a minority of patients.

14 Jul 2010

Metamark Genetics closes $22M Series B financing

Metamark Genetics, Inc., a molecular diagnostics company addressing a major challenge in cancer medicine, has completed a $22 million Series B financing. Metamark's Prognosis Determinants platform has illuminated the genetic drivers governing the lethal metastatic progression of major cancers and is now focused on pivotal translational and commercialization efforts to bring these breakthrough discoveries to cancer patients worldwide.

14 Jul 2010

Researchers discover single genetic mutation that accounts for disease

By inspecting the sequence of all 3 billion "letters" that make up the genome of a single person affected with a rare, inherited disorder, a Johns Hopkins and Duke University team ferreted out the single genetic mutation that accounts for the disease.

13 Jul 2010

New study on impact of bortezomib on mantle cell lymphoma

A new study by researchers from the John Theurer Cancer Center at Hackensack University Medical Center sheds light on how bortezomib (VELCADE-), the first in a new class of cancer drugs known as proteasome inhibitors, works in mantle cell lymphoma. The study also provides preliminary evidence for which patients might benefit most from bortezomib.

13 Jul 2010

GWAS suggests genetic variant with increased oncogene expression for cancer study

The study, published July 13th in Genome Research, showcases a new protocol for studying the activity of cancer-risk variants suggested by GWAS studies. The results also underscore the dramatic consequences of small genetic changes even in the vast stretches of DNA, known as "gene deserts," that do not code for proteins.

13 Jul 2010

Human Genome Sciences, Lonza announce commercial supply agreement for BENLYSTA

Human Genome Sciences, Inc. and Lonza today announced an agreement for the future commercial supply of BENLYSTA® (belimumab), which is currently under regulatory review in the United States and Europe as a potential new treatment for systemic lupus erythematosus (SLE). BENLYSTA is being developed by HGS and GlaxoSmithKline (GSK) under a co-development and commercialization agreement entered into in 2006.

13 Jul 2010

Common SNP in sequence of human genome conferring risk of vascular diseases discovered

Scientists at deCODE genetics and academic colleagues from the Netherlands and twelve other countries across Europe and North America today report the discovery of a common single-letter variation (SNP) in the sequence of the human genome conferring risk of a range of vascular diseases. The SNP confers risk of abdominal aortic aneurysm (AAA), early-onset heart attack, peripheral artery disease (PAD), and pulmonary embolism, independent of other known risk factors.

12 Jul 2010

Researchers explore range of potential new fuel sources in nature

On the long and difficult road toward a carbon-neutral source of transportation fuels, the U.S. Department of Energy is pursuing a diversified approach. This effort involves exploring a range of potential new fuel sources in nature: from plants that may serve as cellulosic feedstocks-fast-growing trees and perennial grasses on land-to oil-producing organisms in aquatic and other environments, such as algae and bacteria.

12 Jul 2010

Genome News and Research

FDA can promote personalized medicine by identying gaps in laboratory operations: ACLA

Research findings may help identify human TOR kinase inhibitors

Study results to help researchers better understand cancer genetics, improve treatment regimens

DNA copying error in autism sufferers discovered

Eurofins MWG Operon, Genomatix Software offer joint services to develop complete human exome array

Key protein in insulin signaling pathway adds insights into development, aging

Keck School of Medicine receives grant for research on biomarker impact on breast cancer screening

NIH awards $38.2M grant to Georgetown-Howard Universities Center for Clinical and Translational Science

Samsung Medical Center, Pfizer form research partnership

BioInvent reports net revenues of SEK 63.1M for January - June 2010 period

Maven Semantic releases updates to Biotechnology research database

Susceptibility to Behcet's disease associated with genes involved in body's immune response

Gene therapy represents safe alternative to current cures for blood disorder β-thalassemia

Metamark Genetics closes $22M Series B financing

Researchers discover single genetic mutation that accounts for disease

New study on impact of bortezomib on mantle cell lymphoma

GWAS suggests genetic variant with increased oncogene expression for cancer study

Human Genome Sciences, Lonza announce commercial supply agreement for BENLYSTA

Common SNP in sequence of human genome conferring risk of vascular diseases discovered

Researchers explore range of potential new fuel sources in nature

Genetics & Genomics - Second Edition eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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