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Genetic risk scores in life insurance underwriting fuel discrimination fears

The integration of genetic risk information, specifically polygenic scores, in life insurance underwriting raises ethical, legal, and social concerns about genetic discrimination, necessitating clear policies and further research.

2 Apr 2024

Uncovering gender-specific genetic alterations in cancer

Recent research spearheaded by Chunmei Cui at the State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, China, casts a new light on the nuanced interplay between gender and cancer, uncovering significant sex-specific disparities in copy number alterations (CNA) across various cancer types.

29 Mar 2024

Research reveals genetic factors in cerebral palsy development

A Canadian-led study has identified genes which may be partially responsible for the development of cerebral palsy.

29 Mar 2024

Personalizing exercise to fight obesity: Study finds genetics influence effectiveness

A recent study in JAMA Network Open reveals that genetic risk influences how physical activity interventions counter obesity, suggesting a personalized approach to exercise based on one's genetic makeup might be more effective in managing obesity.

28 Mar 2024

Unraveling gene regulation's role in pulmonary fibrosis

Regulators of gene expression are thought to play an outsized role in disorders from cancers to heart disease. But how exactly do variations in gene regulation translate into a disease's biology?

28 Mar 2024

Dietary vitamin A shows promise in Alzheimer's disease intervention, study finds

Study explored the impact of dietary vitamin A on gut microbiota and intestinal transcriptome, revealing its potential in Alzheimer's disease (AD) pathology and cognitive functions in mice.

28 Mar 2024

Genetic test streamlines diagnosis of rare developmental disorders

A single genetic test could potentially replace the current two-step approach to diagnosing rare developmental disorders in children. This shift could enable earlier diagnoses for families and save the NHS vital resources.

28 Mar 2024

Using microbiota analysis for health and disease management

The human body harbors approximately 30 trillion microbes, known collectively as the microbiota.

28 Mar 2024

DNA damage in neurons crucial for creating stable memories

Just as you can't make an omelet without breaking eggs, scientists at Albert Einstein College of Medicine have found that you can't make long-term memories without DNA damage and brain inflammation. Their surprising findings were published online today in the journal Nature.

27 Mar 2024

Viral host jumps: Humans to animals transmission more common than previously thought

The evolutionary mechanisms underpinning recent viral host jumps.

27 Mar 2024

Multiomic approach boosts disease prediction accuracy beyond traditional methods

Study highlights the significant enhancement in predicting common diseases like heart disease, diabetes, Alzheimer's, and prostate cancer by integrating polygenic risk scores (PRSs) and gut microbiome scores with conventional risk factors, showcasing the potential of multiomic approaches in personalized medicine.

26 Mar 2024

Vitamin D shows promise in targeting aging's biological mechanisms, study finds

What is currently known about the potential effect of vitamin D (VitD) on modulating some hallmarks of aging.

26 Mar 2024

Molnupiravir influences SARS-CoV-2 evolution in immunocompromised patients

Study found that the antiviral molnupiravir affects the evolution of SARS-CoV-2 in immunocompromised patients, suggesting its use modifies viral mutation patterns and may impact viral evolution.

25 Mar 2024

New method predicts sepsis and organ failure in children

University of Queensland researchers have developed a method to predict if a child is likely to develop sepsis and go into organ failure.

25 Mar 2024

Nucleus Genomics ushers in a new era of personalized medicine to the public

Nucleus Genomics, the next-generation genetic testing and analysis company, today announced the launch of its DNA analysis product to bring the benefits of personalized medicine to everyone.

25 Mar 2024

NIH funds $12.5 million initiative to create the world's first integrated pancreas knowledgebase

Leading investigators in diabetes, pancreas and islet biology, and computational biology have received $12.5 million in two five-year awards from the National Institutes of Health to create the world's first, integrated knowledgebase of human-derived tissue- and cellular-level pancreatic information to support innovative, collaborative and reproducible research.

25 Mar 2024

MUTYH gene mutation linked to increased risk of various solid tumors

A gene associated with colorectal cancer appears to also play a role in the development of other solid tumors, according to a study of over 350,000 patient biopsy samples conducted by researchers at the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins Bloomberg School of Public Health and Foundation Medicine.

25 Mar 2024

Research provides first evidence for a possible cause of familial ALS

Amyotrophic lateral sclerosis (ALS) is a degenerative disease. The neurons responsible for movement begin to die and muscle control is progressively lost, leading to a fatal outcome.

22 Mar 2024

Groundbreaking atlas maps over 80 blood stem cell types

Thanks to an unusual application of game theory and machine learning technology, a large team of scientists led by experts at Cincinnati Children's has published the world's most detailed "atlas" of the many types of stem cells and early progenitors involved in producing human blood from diverse donors.

21 Mar 2024

Scientists shed light on key immune regulators involved in Alzheimer’s and other disorders of lipid-rich tissues

Using novel genetic and genomic tools, researchers at the Icahn School of Medicine at Mount Sinai have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer's and other diseases.

21 Mar 2024