Genomic News and Research

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Alarming trends in sexually transmitted diseases (STDs) among America's young people

A study by ASHA, sponsored by Roche Diagnostics of Indianapolis, Indiana is being released in conjunction with April's STD Awareness Month and demonstrates that the incident rate of STDS in youth (ages 15-24) have increased dramatically in recent years.

12 Apr 2005

Fifteen-year hunt uncovers gene behind pseudothalidomide syndrome

A team of scientists from Colombia, the United States and elsewhere has successfully completed a 15-year-plus search for the genetic problems behind the very rare Roberts syndrome, whose physical manifestations often include cleft lip and palate and shortened limbs that resemble those of babies whose mothers took thalidomide during pregnancy.

11 Apr 2005

Findings will stir new research in bacterial evolution

Bacteria acquired up to 90 percent of their genetic material from distantly related bacteria species, according to new research from The University of Arizona in Tucson.

7 Apr 2005

Researchers set a new standard in the design and engineering of nuclear hormone receptor-based genetic on-off switches

Researchers at the University of Illinois at Urbana-Champaign have set a new standard in the design and engineering of nuclear hormone receptor-based genetic on-off switches, without causing new problems or aggravating existing ones.

7 Apr 2005

Genomic DNA provides clues to new advances in cancer diagnostics

Researchers at the University of Illinois at Chicago have identified a method of assessing the malignant potential of cells based on the sensitivity of cellular DNA to enzyme digestion.

22 Mar 2005

ParAllele BioScience announces key patent issuance

ParAllele BioScience has announced the issuance by the U.S. Patent Office of a key patent (6,858,412) covering its Molecular Inversion Probe (MIP) technology. The patent is owned by Stanford University and is exclusively licensed to ParAllele.

21 Mar 2005

Genomic analysis may one day be a primary diagnostic tool for physicians deciding on a course of treatment for trauma

The researchers showed that state-of-the-art techniques for rapidly analyzing changes in activity of all human genes will likely produce useful insights into the health of critically ill patients. The findings, which are available online and will be published in the March 29 issue of the Proceedings of the National Academy of Sciences, make it possible for physicians to begin answering important questions about critical care through genomic analysis.

21 Mar 2005

DNA weak links may provide clues to cancer biology

The chromosomes of mammals, including humans, contain regions that are particularly prone to breaking under conditions of stress and in cancer. Now, new research by geneticists at Duke University Medical Center finds that yeast cells also contain such weak links in DNA and begins to reveal the molecular characteristics of these links that might help to explain them.

13 Mar 2005

Genetic examinations of trauma, burn victims produce consistent results

A genetic tool with the potential to identify which trauma and burn patients are most likely to become seriously ill has worked consistently in a wide range of experimental clinical settings - an important hurdle to overcome before the method is routinely used in emergency rooms and intensive care units.

7 Mar 2005

DNA ejection from single phage particles

Studying phage, a primitive class of virus that infects bacteria by injecting its genomic DNA into host cells, researchers have gained insight into the driving force behind this poorly understood injection process, which has been proposed in the past to occur through the release of pressure accumulated within the viral particle itself.

7 Mar 2005

Air Genome Project to sample air using whole genome shotgun sequencing

The J. Craig Venter Institute is launching a pilot project to better understand the diversity of microbes in urban air. In addition to more deeply characterizing the microbes we breathe every day, researchers anticipate that the results will provide information vital to designing systems that detect potentially dangerous biological substances in the air.

7 Mar 2005

Genome clues to amoebic dysentery

Each year, there are an estimated 50 million cases of amoebic dysentery, causing up to 100,000 deaths, mostly in developing countries. On Thursday 24 February 2005, researchers at the Wellcome Trust Sanger Institute and their colleagues reported in Nature magazine the genome sequence of the parasite that causes the disease, Entamoeba histolytica.

1 Mar 2005

Caution against FDA approval of race-based pharmaceutical

New York University Sociologist Troy Duster concludes that a pharmaceutical to combat heart disease among blacks is based on faulty research and urges the Food and Drug Administration to obtain more reliable data before approving the drug.

27 Feb 2005

Common epigenetic problem doubles cancer risk

In experiments with mice, a team of scientists from the United States, Sweden and Japan has discovered that having a double dose of one protein is sufficient to change the normal balance of cells within the lining of the colon, thereby doubling the risk that a cancer-causing genetic mutation will trigger a tumor there.

27 Feb 2005

Novel genetic test helps detect mutations that may be missed by conventional DNA test

Researchers have identified a genetic test that when used with DNA testing would detect a higher number of genetic mutations in colorectal cancer patients, according to a study in the February 16 issue of JAMA, a theme issue on medical applications of biotechnology.

15 Feb 2005

The link between intelligence and dementia

Scientists have turned to the brightest brains in Britain in a bid to understand the link between intelligence and dementia.

15 Feb 2005

New primate-specific gene family that spans about 10% of human chromosome 2

A team of scientists led by Peer Bork, Ph.D., Senior Bioinformatics Scientist at the European Molecular Biology Laboratory, report today in the journal Genome Research that they have identified a new primate-specific gene family that spans about 10% of human chromosome 2.

13 Feb 2005

Findings could lead to new asthma treatment based on individual genetic profiles

Children who suffer from acute asthma attacks share a genetic profile that appears to be unique to these children, according to a new study by researchers at Cincinnati Children's Hospital Medical Center. The discovery opens the door to the possibility of designing treatments specifically tailored to children who suffer from the severest forms of asthma.

7 Feb 2005

Novel nanotechnology detects human DNA mutations

Researchers at Nanosphere, Inc. have reported unprecedented benefits in the company's technology for the medical analysis of human DNA.

26 Jan 2005

New insight into how tumor cells can become resistant to anti-cancer therapy

The scientists observed that a protein called P-glycoprotein (P-gp), which causes resistance to chemotherapy in many tumor types, is able to physically “jump” or transfer between tumor cells and retain its functional properties, protecting otherwise sensitive cells from the effects of anti-cancer treatment in vivo and in vitro.

18 Jan 2005