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PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

The investigational PARP inhibitor talazoparib caused regression of patient-derived xenografts (PDXs) of triple-negative breast cancers (TNBC) that had BRCA mutations and also those that did not have BRCA mutations but had other alterations in DNA damage-repair pathways.

1 Nov 2017

‘Precision Medicine’ may not always be so precise when applied to diverse populations, study says

Precision Medicine in oncology, where genetic testing is used to determine the best drugs to treat cancer patients, is not always so precise when applied to some of the world's more diverse populations, according to a study led by the Translational Genomics Research Institute, an affiliate of City of Hope, and the Keck School of Medicine of the University of Southern California.

27 Oct 2017

Dream Team plans to stop pancreatic cancer before symptoms occur

Deeply entrenched and mature by the time it's found, pancreatic cancer is one of the hardest to defeat. A Dream Team assembled by Stand Up to Cancer and led by an investigator at The University of Texas MD Anderson Cancer Center will test new ways to find the disease in its emerging, more vulnerable phase in people who are at high risk for developing it.

26 Oct 2017

Scientists uncover new clues to male infertility or congenital illness

When it comes to male reproductive fertility, timing is everything. Now scientists are finding new details on how disruption of this timing may contribute to male infertility or congenital illness.

19 Sep 2017

Myriad Genetics presents positive results of new hereditary cancer test at 36th annual conference of NSGC

Myriad Genetics, Inc., a leader in molecular diagnostics and personalized medicine, today announced that two important studies will be featured in podium presentations at the 36th annual conference of the National Society of Genetic Counselors in Columbus, OH.

18 Sep 2017

Multigene panel test could be useful to detect patients with hereditary kidney cancer syndrome

A multigene panel test could be a useful diagnostic tool to help clinicians identify patients with a hereditary kidney cancer syndrome, according to the results of a study published in Cancer.

13 Sep 2017

Study: Maintenance therapy increases progression-free survival in BRCA mutant recurrent ovarian cancer

Rucaparib maintenance therapy increases progression-free survival in BRCA mutant recurrent ovarian cancer by 77%, according to late-breaking results from the ARIEL3 trial reported today at the ESMO 2017 Congress in Madrid.

8 Sep 2017

Research identifies new gene fusions and mutations linked to GIST tumors

Researchers at UC San Diego Moores Cancer Center, with colleagues from Memorial Sloan Kettering Cancer Center and Fox Chase Cancer Center, have determined that a specific region of the small bowel, called the duodenal-jejunal flexure or DJF, shows a high frequency of gastrointestinal stromal tumors (GISTs) with mutations of the NF1 gene

18 Aug 2017

Novel blood test identifies tumor-derived DNA in early-stage cancer patients

In a bid to detect cancers early and in a noninvasive way, scientists at the Johns Hopkins Kimmel Cancer Center report they have developed a test that spots tiny amounts of cancer-specific DNA in blood and have used it to accurately identify more than half of 138 people with relatively early-stage colorectal, breast, lung and ovarian cancers.

17 Aug 2017

Genome editing – public perceptions studied

Genome editing is fast becoming a norm with more and more research teams working on this arena and coming up with new cutting edge developments. However attitudes towards genetic modifications vary with several opinions – political, moral and religious, raising concerns.

11 Aug 2017

Study shows new method for repairing disease-causing mutation in human embryos

Scientists have demonstrated an effective way of using a gene-editing tool to correct a disease-causing gene mutation in human embryos and stop it from passing to future generations.

3 Aug 2017

Researchers ferreting out patients most likely to become resistant to cancer treatment

According to the National Cancer Institute, the number of people beating a cancer diagnosis reached nearly 14.5 million in 2014 and is expected to rise to almost 19 million by 2024. Now, that's good news, but it doesn't mean that cancer researchers - in the lab or clinic - are resting on any laurels.

2 Aug 2017

US scientists make advances in modifying human embryos

American Scientists have managed to edit and improve the DNA of human embryos in an effort to correct the gene defects that cause inherited diseases.

27 Jul 2017

Study identifies new mutations linked to hereditary neuroendocrine tumors

Pheochromocytomas and paragangliomas are rare neuroendocrine tumors with a strong hereditary component. Half the genes whose alterations confer hereditary susceptibility to develop this condition code for enzymes involved in the Krebs cycle, a metabolic route involved in cellular respiration.

20 Jul 2017

Researchers suggest new strategy to identify germline mutations in men with prostate cancer

Scientists have had limited success at identifying specific inherited genes associated with prostate cancer, despite the fact that it is one of the most common non-skin cancers among men.

29 Jun 2017

New approach finds statistical evidence that ancient gene variants contribute to autism

The way you measure things has a lot to do with the value of the results you get. If you want to know how much a blueberry weighs, don't use a bathroom scale; it isn't sensitive enough to register a meaningful result.

22 Jun 2017

Genetic mutation could be cause of severe eczema, research finds

A genetic mutation could be the cause of severe eczema, according to new research published June 19 in Nature Genetics by researchers at the Uniformed Services University of the Health Sciences.

20 Jun 2017

Research findings lay groundwork for developing more targeted treatments for deadly neuroblastomas

Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research by the University of Chicago Medicine. The findings lay the groundwork for developing more targeted treatments for particularly deadly variations of the cancer.

20 Jun 2017

Researchers discover mutations in CARD11 gene that lead to eczema

Researchers have identified mutations in a gene called CARD11 that lead to atopic dermatitis, or eczema, an allergic skin disease.

19 Jun 2017

Nagoya University research identifies skin disease inherited as germline mutation from father

Nagoya University research identified a patient with the whole-body skin disease epidermolytic ichthyosis that had been inherited as a germline mutation from her father with the milder epidermolytic nevus.

16 Jun 2017