Glioblastoma News and Research

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Glioblastoma is the most aggressive and malignant form of glioma, a type of primary brain cancer. Surgery is often used to treat gliomas, along with radiation. However, since surgery and radiation fail to cure the disease, doctors may turn to additional radiation or chemotherapy. In early stages glioblastoma tumors often grow without symptoms and therefore can become quite large before symptoms arise. When the tumor becomes symptomatic, tumor growth is usually very rapid and is accompanied by altered brain function, and if left untreated the disease becomes lethal. Although primary treatment is often successful in temporarily stopping the progression of the tumor, glioblastomas almost always recur and become lethal.

Combination of two targeted drugs shows "clinically meaningful" activity in some malignant brain tumors

A combination of two targeted cancer drugs showed unprecedented, "clinically meaningful" activity in patients with highly malignant brain tumors that carried a rare genetic mutation, according to a clinical trial report by investigators from Dana-Farber Cancer Institute.

25 Nov 2021

Novel protein regulator of tumor angiogenesis may be a therapeutic target for difficult-to-treat cancers

A novel protein regulator of tumor angiogenesis, TMEM230, was recently characterized by researchers to have a role in tumor development and vascularization, with potential as a target for anti-tumor therapy in difficult-to-treat cancers such as glioblastoma.

23 Nov 2021

Researchers find a new way to analyze diseased and healthy cells from brain tumor patients

Scientists studying the most common and aggressive type of brain tumor in adults have discovered a new way of analyzing diseased and healthy cells from the same patient.

22 Oct 2021

Study reveals a link between neuroinflammation protein and survival outcomes in glioblastoma patients

Scientists have discovered a new link that could bring the scientific and medical community closer to understanding why glioblastoma, the most common malignant brain tumor, is deadlier in males than females.

18 Oct 2021

Wyss Center to lead a collaborative project aimed at improving brain cancer treatment

The Wyss Center announced today that it will lead a collaborative project, as part of Wellcome Leap's Delta Tissue Program, to improve understanding of the brain cancer glioblastoma (GBM) and help develop more effective therapies.

8 Oct 2021

Newly developed gel helps improve the effectiveness of immunotherapy in glioblastoma

Pairing a newly developed gel with immunotherapy that was delivered to post-surgical mouse brains with glioblastoma, a highly malignant and deadly cancer, improved the immunotherapy's effectiveness, report researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and colleagues. The findings appeared on Oct. 6, 2021, in Science Advances.

7 Oct 2021

Northwestern’s SPORE has made advances in understanding the genetic basis of glioblastoma

Glioblastoma is one of the deadliest cancers known to man. While the advent of immunotherapy and other cutting-edge treatments have prolonged life for people afflicted with other types of cancer, the prognosis for glioblastoma has remained relatively constant: just 18 months.

3 Oct 2021

Advanced technique offers new insights about the dynamics of gliomas

A team led by researchers at Weill Cornell Medicine, the New York Genome Center, Harvard Medical School, Massachusetts General Hospital and the Broad Institute of MIT and Harvard has profiled in unprecedented detail thousands of individual cells sampled from patients' brain tumors.

2 Oct 2021

Long-held theory of cancer-induced immune suppression requires revision, study says

Many cancers produce an enzyme called IDO that suppresses immune system activity, but the long-held hypothesis of how this mechanism operates requires revision, according to a study published in Clinical Cancer Research.

29 Sep 2021

Small molecule drug can attenuate the triggers of neuroinflammation, preclinical study shows

Neuroinflammation can worsen outcomes in stroke, traumatic brain injury, or spinal cord injury, as well as accelerate neurodegenerative diseases like ALS, Parkinson's, or Alzheimer's. This suggests that limiting neuroinflammation may represent a promising new approach to treat neurological diseases and neuropathic pain that are driven by neuroinflammation.

24 Sep 2021

Sex, age are crucial factors in the care and survival of patients with malignant brain tumors

Findings from a national study by researchers at Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and external collaborators suggest that sex and age are crucial factors in the care and survival of patients with malignant brain tumors and other central nervous systems (CNS) cancers.

23 Sep 2021

Novel cell reprogramming offers a promising therapeutic strategy to slow down glioblastomas

Gliomas are the most common primary brain tumors in adults. Among them, high-grade glioblastomas (GBMs) are particularly known to be notoriously aggressive and invasive, which makes it challenging to treat them. The disease rapidly progresses to an advanced stage in a short span of time, and the survival of such patients is often dismal.

16 Sep 2021

Results from Phase 0/1 trial of ribociclib plus everolimus in patients with high-grade glioma announced

The Ivy Brain Tumor Center at Barrow Neurological Institute, the largest early-phase drug development program for brain cancer in the world, announced results from their Phase 0/1 clinical trial of ribociclib plus everolimus in patients with high-grade glioma (HGG).

13 Sep 2021

Targeting and inhibiting a protein could provide more effective treatment for brain cancer

McGill University researchers identify proteins that drive cancer stem cells. Targeting and supressing a particular protein called galectin1 could provide a more effective treatment for glioblastoma, in combination with radiation therapy.

31 Aug 2021

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

Glioblastoma News and Research

Further Reading

Combination of two targeted drugs shows "clinically meaningful" activity in some malignant brain tumors

Novel protein regulator of tumor angiogenesis may be a therapeutic target for difficult-to-treat cancers

Researchers find a new way to analyze diseased and healthy cells from brain tumor patients

Study reveals a link between neuroinflammation protein and survival outcomes in glioblastoma patients

Wyss Center to lead a collaborative project aimed at improving brain cancer treatment

Newly developed gel helps improve the effectiveness of immunotherapy in glioblastoma

Northwestern’s SPORE has made advances in understanding the genetic basis of glioblastoma

Advanced technique offers new insights about the dynamics of gliomas

Long-held theory of cancer-induced immune suppression requires revision, study says

Small molecule drug can attenuate the triggers of neuroinflammation, preclinical study shows

Sex, age are crucial factors in the care and survival of patients with malignant brain tumors

Novel cell reprogramming offers a promising therapeutic strategy to slow down glioblastomas

Results from Phase 0/1 trial of ribociclib plus everolimus in patients with high-grade glioma announced

Targeting and inhibiting a protein could provide more effective treatment for brain cancer

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Study assesses contemporary burden of brain and other CNS tumors in the U.S

ICL fluorescent label homogenously penetrates the glioblastoma brain tumors

3D-printed tumors potentially next step in personalized medicine

Arteriolar niche used by breast cancer cells to prepare for metastasis

Researchers create the first 3D-bioprinted model of active glioblastoma tumor

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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