Glucocorticoid is a compound that belongs to the family of compounds called corticosteroids (steroids). Glucocorticoids affect metabolism and have anti-inflammatory and immunosuppressive effects. They may be naturally produced (hormones) or synthetic (drugs).
A new study explores how acute stressors affected mice in terms of their immune responses in specific regions of the brain.
Isabella Salamone is an eighth-year student in the Driskill Graduate Program in Life Sciences (DGP) who is studying sexual dysmorphism in mice in the laboratory of Elizabeth McNally, MD, PhD, the Elizabeth J. Ward Professor of Genetic Medicine and director of the Center for Genetic Medicine.
There is a steadily growing arsenal of drugs for COVID-19. Researchers from Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität (FU) Berlin have studied the mechanisms of action of antiviral and anti-inflammatory drugs.
Researchers assess the impact of interval administration of LD-IL-2 was examined in 18 T1D patients who received a three-day dosing interval.
A recent study by the TU Dresden and the University of Zurich in cooperation with the Max Planck Institute for the Science of Light establishes for the first time a link between depressive disorders and mechanical characteristics of all major blood cell types.
Obese mice that were fed a high-fat diet and that received prednisone one time per week had improved exercise endurance, got stronger, increased their lean body mass and lost weight, reports a new Northwestern Medicine study published in The Journal of Experimental Medicine.
Researchers reported the association of a single nucleotide polymorphism rs9984273 in the interferon-alpha/beta receptor gene with outcomes of acute respiratory distress syndrome and COVID-19.
Glucocorticoid steroids improved muscle performance through distinct, sex-specific molecular mechanisms in mice, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.
A new study reports finds very low aldosterone levels in a subset of COVID-19 patients.
A new study describes the efficacy of adenosine receptor agonists in the treatment of SARS-CoV-2 infection.
Voluntary fasting, for example interval fasting, is beneficial to health for many people, depending on their individual condition. For example, controlled periods of starvation can prevent and improve diseases such as diabetes and obesity.
Dexamethasone, a glucocorticoid with anti-inflammatory and immunosuppressive effects, can transiently increase the expression of therapeutic genes delivered using adeno-associated virus (AAV) vectors.
Researchers of the University of Bologna carried out a study on murine models (mice) demonstrating that pre-natal exposure to nicotine and its by-products produces long-term effects on sleep and stress-response in some areas of the brain.
In a new study, researchers used per protocol bronchoalveolar lavage fluid (BALF) samples after intubation to evaluate the transcriptomic profiles of the local pulmonary host responses during early-stage severe coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (CARDS), non-COVID-19 ARDS, and sepsis.
Drugs we take like prednisone can weaken our bones and so can aging, and scientists working to prevent both have some of the first evidence that the best target may not be the logical one.
A team of US-based scientists has recently explored various risk factors associated with the poor prognosis of coronavirus disease 2019 (COVID-19). They have identified thrombosis-related risk factors as a major predictor of in-hospital COVID-19 related mortality. The study is currently available on the medRxiv* preprint server while awaiting peer review.
New research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows that in one study, the majority of rheumatoid arthritis patients on an ultra-low dose of the drug rituximab maintained low disease activity for up to four years, and rarely needed to switch to other biologic drugs or glucocorticoids to control their disease.
New research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows that pregnant women with Takayasu's arteritis, a type of large-vessel vasculitis, appear to have a high prevalence of serious maternal and fetal adverse outcomes.
A study measured neutralization of SARS-CoV-2 and vaccine responses in immunocompromised patients with systemic inflammatory diseases.
A recent study discusses the clinical characteristics and outcomes of patients with SARDs who were previously vaccinated against SARS-CoV-2.