Glutamine News and Research

RSS

Glutamine is an amino acid used in nutrition therapy. It is also being studied for the treatment of diarrhea caused by radiation therapy to the pelvis.

Ground breaking discovery could lead to new anti TB drugs

New drugs to treat strains of TB which have become resistant to treatment are now a possibility following a ground breaking discovery from the University of Surrey.

4 Dec 2019

New drug combo may improve pancreatic cancer therapy

A new study by scientists at Sanford Burnham Prebys Medical Discovery Institute have discovered a combination of two cancer-fighting drugs that successfully worked on pancreatic tumor in mice, shrinking them significantly, and paving the way for a speedy clinical trial designed to test their efficacy in humans.

18 Nov 2019

Protein that drives pancreatic cancer growth could be new treatment target

A protein that drives growth of pancreatic cancer, and which could be a target for new treatments, has been identified by researchers at the Crick.

12 Nov 2019

Glutamine-blocking compound slows cancer growth, unleashes anti-tumor immune response

A compound developed by Johns Hopkins researchers that blocks glutamine metabolism can slow tumor growth, alter the tumor microenvironment and promote the production of durable and highly active anti-tumor T cells.

10 Nov 2019

Study: SDHI pesticides induce oxidative stress and kill human cells

Mitochondria are organelles that are present in eukaryotic cells. They contain respiratory chains that are crucial for the survival of organisms.

7 Nov 2019

Human regenerative capacity discovered

Move over, salamanders, we humans can also regrow some of our body tissues. At least, this is what a new study published on October 9, 2019, in the journal Science Advances, reports. Using a mechanism quite similar to that by which amphibians like salamanders, and some zebrafish, grow back lost body parts, human joint cartilage can also regenerate itself.

10 Oct 2019

Horizon Discovery announces full commercial licensing of GS knockout CHO K1 cell line to Glenmark

Horizon Discovery Group plc, a global leader in the application of gene editing and gene modulation for cell line engineering, today announced the full commercial licensing to Glenmark Pharmaceuticals, a global innovative pharmaceutical company, of its gene-edited Glutamine Synthetase knockout Chinese Hamster Ovary K1 cell line. Terms of the agreement were based on stringent evaluation of the cell line by Glenmark to assess its suitability for adoption into the Company’s biomanufacturing processes.

From Revvity 30 Sep 2019

Research: Protein complex represents a new metabolic target for liver cancer

Disrupting a metabolic pathway in the liver in a way that creates a more "cancer-like" metabolism actually reduces tumor formation in a mouse model of liver cancer.

24 Sep 2019

Version of an antibiotic drug extends survival in mice with lethal pediatric brain tumors

Versions of an antibiotic drug called DON first isolated from soil bacteria more than 60 years ago have shown promising signs of extending survival in mice models of especially lethal pediatric brain tumors marked by the high expression of a cancer-causing gene known as the MYC oncogene, according to results of two studies from researchers at the Johns Hopkins Kimmel Cancer Center.

23 Sep 2019

Faster, cheaper, better: improved gene therapy tool production

The heart of modern therapy is increasingly personalized and targeted at specific cellular or genetic deficits. This requires gene therapy, in many cases. A new study, published on 19 September 2019 in the journal Nature, describes an improved way to produce purified gene carrier viruses called AAVs cheaply and quickly, from the culture medium.

22 Sep 2019

Researchers identify compounds that influence time to sexual maturity and lifespan

Every day, people are exposed to myriad chemicals, both natural and synthetic. Some of these compounds may affect human physical development, but testing them directly on people would be grossly unethical.

20 Aug 2019

Liver dysfunction provokes cerebral molecular disturbances in two weeks

The liver plays a vital role as a filter in the human body. But what happens when it malfunctions? Researchers from the Universities of Geneva and Lausanne, the Vaud University Hospital Centre, the Centre for Biomedical Imaging, the Federal Polytechnic School of Lausanne and the University Hospitals of Geneva, Switzerland, teamed up to perform a detailed analysis of hepatic encephalopathy, a type of brain damage caused by chronic liver disease.

19 Aug 2019

Thioredoxin antioxidant could soon be used to improve cancer treatment

Researchers from Medical University of South Carolina (MUSC) have discovered the use of thioredoxin – a naturally occurring antioxidant to modulate T cells of the immune system. This may be a big step towards improving currently used immune therapies such as adoptive T-cell therapy (ACT) and hematopoietic stem cell transplantation (HSCT).

8 Jul 2019

Researchers determine atomic interactions that stabilize phase-changing proteins

Most of the well-studied proteins in our bodies are like metal; some can change shape easily, like aluminum foil, and others are rigid, like steel beams, but they typically have a solid, well-defined structure.

2 Jul 2019

Chemical changes in the brain may be associated with unexplained motor symptoms

A new study finds that people who have movement problems, symptoms that cannot be explained by an underlying disease, may have chemical changes in specific areas of the brain.

6 Jun 2019

Tumor-fighting combination targets aggressive form of brain cancer

Researchers have paired a specialized diet and a tumor-fighting drug and found the non-toxic combination helps to destroy the two major cells found in an aggressive form of brain cancer, the team reports in the online edition of the Nature group journal Communications Biology.

31 May 2019

Mining 25 years of data reveals new insights into predicting the age of onset for Huntington disease

Investigators at the University of British Columbia/Centre for Molecular Medicine & Therapeutics and BC Children's Hospital have examined more than 25 years of data to reveal new insights into predicting the age of onset for Huntington disease.

18 May 2019

Brazilian researchers develop new strategy to starve triple negative breast cancer cells

A team of Brazilian researchers has developed a strategy that slows the growth of triple negative breast cancer cells by cutting them off from two major food sources.

13 May 2019

Johns Hopkins researchers uncover role of neurotransmitter in the spread of aggressive cancers

Using human cancer cells, tumor and blood samples from cancer patients, researchers at Johns Hopkins Medicine have uncovered the role of a neurotransmitter in the spread of aggressive cancers. Neurotransmitters are chemical "messengers" that transmit impulses from neurons to other target cells.

25 Apr 2019

Researchers identify cause of inherited metabolic disorder

A new study from BC Children's Hospital, the University of British Columbia (UBC) and an international team of researchers published in the New England Journal of Medicine is the first to identify a rarely-seen type of DNA mutation as the cause of an inherited metabolic disorder.

16 Apr 2019