Glycans News and Research

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Mutational targets of SARS-CoV-2 receptor-binding domain for vaccine-antiviral development

The COVID-19 pandemic has spread throughout the whole world within six months, causing millions of infections and hundreds of thousands of deaths. Yet there is no effective vaccine or antiviral to deal with it.

18 Jun 2020

Combination of antibodies and internal radiation can help fight cervical cancer

The sugar coating on cancer cells helps them thrive, and a new study indicates patients with cervical cancer who make antibodies to those sugars appear to do better when they also receive internal radiation therapy.

16 Jun 2020

Developing a new rapid test for COVID-19

News-Medical speaks to Professor Matt Gibson about his groundbreaking research where his team has developed a new rapid test for COVID-19 detection.

15 Jun 2020

Researchers are developing new diagnostic tool for rapid detection of coronavirus

Coronavirus diagnostics currently require centralized facilities and collection/distribution of swabs and results are 'next day'.

15 Jun 2020

Glycans "lock and load" the SARS-CoV-2 spike protein for infection

A new study by scientists from the University of California San Diego, USA and Maynooth University, Ireland and published on the preprint server bioRxiv* in June 2020 reports preliminary results showing that the spike protein of the SARS-CoV-2, as well as its glycan coat, has “hitherto unseen functional and structural” properties. These may be useful in designing novel therapeutics to target this molecule.

14 Jun 2020

Bruker introduces breakthrough MALDI-2 source on timsTOF fleX, and further innovations in CCS-enabled 4D proteomics on timsTOF

At the virtual ASMS 2020 Reboot conference, Bruker Corporation today announces a major advance in matrix-assisted laser desorption ionization (MALDI) with the launch of the world’s first commercial MALDI-2 post-ionization (PI) source, which is now available as an option on the timsTOF fleXTM ESI/MALDI mass spectrometer.

From Bruker Life Sciences Mass Spectrometry 3 Jun 2020

New test may help detect prostate cancer earlier and with greater accuracy

A new type of test that uses complex sugars to detect prostate cancer earlier and with greater accuracy is being developed by researchers at the University of Birmingham.

29 May 2020

Novel insights on SARS-CoV-2 cell entry may inform further vaccine and treatment development

A research group from Harvard Medical School reported two cryo-electron microscopy structures derived from a single preparation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein in their paper available on the preprint server bioRxiv. Understanding the nuances of prefusion and postfusion conformations shed light on viral cell entry and may, in turn, guide the development of vaccines and drugs.

18 May 2020

New and unexplored angle in the binding of SARS-CoV-2 to host cells

Researchers in the Netherlands, Cuba, and Italy have made important discoveries about the carbohydrate-mediated binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein to host cell lectin receptors and host lung microbiota.

17 May 2020

Researchers make a significant leap in mucus biology

Worldwide, hundreds of millions of people are impacted by chronic respiratory disease. COPD alone affects more than 250 million people, causing 3 million deaths each year.

13 May 2020

Research on SARS-CoV-2 spike protein may lead to new vaccines and treatments

The virus that causes COVID-19 is studded on its exterior with "spike proteins," a key component in its ability to infect human cells. Two University of Georgia researchers, Rob Woods and Parastoo Azadi, are investigating the proteins and sugars on the surface of the virus with the goal of finding information that could lead to vaccines and therapeutics.

28 Apr 2020

Study reveals the coronavirus camouflage that will aid vaccine design

Research led by the University of Southampton has revealed the fundamental features of the SARS-CoV-2 coronavirus that causes COVID19.

8 Apr 2020

Origins of SARS-CoV-2 – natural or man-made?

With over 780,000 individuals across the world infected and over 37,000 dead, the world is gripped by the pandemic caused by the novel strain of coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

30 Mar 2020

Changes in surface sugarlike molecules help cancer cells to spread

Changes in a specific type of sugarlike molecule, or glycan, on the surface of cancer cells help them to spread into other tissues, according to researchers at the University of California, Davis. Published March 23 in Proceedings of the National Academy of Sciences, the work could lead to diagnostic tests and new therapies to slow or stop the spread of cancers.

25 Mar 2020

Researchers elucidate structure and function of enzyme that builds complex sugar trees

Researchers have used cryo-electron microscopy to elucidate for the first time the structure and function of a very small enzyme embedded in cell membranes.

27 Feb 2020

Do biologists and physicists approach AFM differently?

This was the question at the forefront of my mind as I attended the Linz Winter Workshop back in February. Do biologists and physicists approach AFM differently and, does it matter?

From Nu Nano Ltd 28 Jan 2020

Taming pathogens with mucus and phages

Millions of people are treated with antibiotics each year for infections or as a preventative measure. The Centers for Disease Control and Prevention reports that at least 2.8 million people are infected with antibiotic-resistant bacteria each year, meaning the germs have found ways to overpower antibiotics and continue to grow.

24 Jan 2020

How SpatialOMx is Delivering New Insights into Disease Research

An interview with Shannon Cornett Ph.D, discussing the use of MALDI-guided spatial molecular analysis for biomarker discovery.

From Bruker Life Sciences Mass Spectrometry 14 Jan 2020

Study of glycobiology and glycan diagnostics in personalized medicine featured in OMICS special issue

An in-depth look at the science of glycobiology and glycan diagnostics, and their promise in personalized medicine in the current post-genomic era are featured in a special issue of OMICS: A Journal of Integrative Biology, the peer-reviewed interdisciplinary journal published by Mary Ann Liebert, Inc., publishers.

13 Jan 2020

Measuring glycans in samples of antibodies

When Lorna De Leoz invited laboratories to participate in her glycomics study, she hoped for 20 responses. Instead, she was deluged by emails from around the world.

2 Jan 2020