Glycolysis News and Research

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Glycolysis is a series of reactions that helpextract energy from glucose. This is an ancient pathway of metabolism that is present in the majority of living organisms today. It is the foundation of both aerobic and anaerobic cellular respiration. It takes place in the cytosol of a cell and is the foundation of both aerobic and anaerobic cellular respiration.

Sleeping sickness parasite exhibits metabolic flexibility and adaptability

Parasitic protozoa called trypanosomes synthesize sugars using an unexpected metabolic pathway called gluconeogenesis, according to a study published December 27 in the open-access journal PLOS Pathogens by David Horn of the University of Dundee in the UK, and colleagues.

28 Dec 2018

New approach to destroy HIV reservoirs

Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified the characteristics of CD4 T lymphocytes that are preferentially infected by the virus - it is their metabolic (or energy-producing) activity1 that enables the virus to multiply.

21 Dec 2018

New research examines cancer metabolism at multiple scales

No matter what form cancer takes in the body, it starts at the cellular level and grows via metabolism run amok.

21 Dec 2018

Study finds how pyruvate helps improve cardiac output in pediatric patients with LCOS

Can pyruvate, the end product of glycolysis, help improve cardiovascular function in children who have cardiopulmonary bypass surgery and suffer from low cardiac output syndrome? This question is one that Rafael Jaimes, Ph.D., a staff scientist at Children's National Heart Institute, a division of Children's National Health System, is studying, thanks to a two-year grant from the American Heart Association.

19 Dec 2018

Deadly combination: Drug cocktail induces cancer cell death by switching off energy supply

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth - this was discovered by researchers from the University of Basel's Biozentrum two years ago. In a follow-up study, recently published in Cell Reports, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

11 Dec 2018

Study shows for the first time how a specific cell gene affects transformation of others

An international team of seven institutions from Spain and the US including the University of Valencia has discovered for the first time that the biological activity of the c-MYC gene is necessary so that cell reprogramming occurs, that is, the process by which a specialised cell -for example, a neuron- is transformed into a different cell type.

30 Nov 2018

Researchers elucidate central mechanisms of salt-induced hypertension through sympathetic activation

Hypertension is a major risk factor for cardiovascular disease worldwide, and approximately 40% (1 billion) of adults aged 25 and above have been diagnosed with hypertension. A positive correlation between salt intake and blood pressure has long been postulated.

30 Nov 2018

Researchers discover pathway for enhancing the self-repair efforts of injured kidneys

A team of researchers led by Jonathan Stamler, MD, of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, has discovered a pathway for enhancing the self-repair efforts of injured kidneys.

29 Nov 2018

Restricting cancer metabolism could make oncolytic viruses more effective at attacking tumors

Restricting the ability of cancer cells to metabolise sugar could make oncolytic viruses more effective at attacking them, suggests a study published today in the journal Cancer Research.

29 Nov 2018

Cancer stem cells depend on amino acid metabolism, and it's proving to be their Achilles' heel

Think of energy metabolism like a party popper: Ripping something apart releases a bang. Most of your cells rip apart sugar to release the "bang" of energy. Sometimes they rip apart fats, and in a pinch, cells can even metabolize protein.

13 Nov 2018

Study offers hope of early detection, treatment of liver cancer

Liver cancer is the second leading cause of cancer-related mortality worldwide, claiming 700,000 lives each year. Most cases are discovered too late for a cure -- but now a study offers hope of early detection, and targets for new treatments.

31 Oct 2018

Study: Matcha green tea kills breast cancer stem cells

MATCHA, the Green Tea packed with antioxidants, is often hailed as containing properties which prevent disease.

30 Aug 2018

Novel approach reveals metabolic vulnerabilities in kidney cancer

In order to halt the growth of cancer cells, you have to know what feeds them. Researchers at the nationally recognized Kidney Cancer Program at UT Southwestern's Harold C. Simmons Comprehensive Cancer Center have developed a novel approach using glucose that may open up new opportunities for therapeutic intervention.

30 Aug 2018

Study suggests new strategies for using cell metabolism to treat cancer

Researchers at the University of Cincinnati College of Medicine have discovered that cell metabolism plays an important role in the ability of cells to start a survival program called autophagy, an unwanted side effect of some anti-cancer drugs that helps some tumor cells dodge treatment and eventually regrow into new tumors.

29 Aug 2018

Researchers describe link between poor oocyte development and oxidative stress in obese mice

Excessive body fat is associated with negative effects on female fertility and pregnancy. In mice, maternal obesity impairs proper development of egg precursor cells called oocytes.

17 Aug 2018

Exosomes: Are They All Alike and Why Does it Matter?

In this interview, Haiying Zhang, Assistant Professor of Cell and Development Biology from the Department of Pediatrics at Weill Cornell Medicine talks to News – Medical about the importance of Exosomes.

From Waters | Wyatt Technology 1 Aug 2018

New proteomics studies help gain more insights into Alzheimer's, cancer and listeriosis

The brains of people with Alzheimer's disease contain many protein aggregates outside of cells, known as plaques. These are mainly made of the peptide amyloid-beta, which is released from the plasma membrane when the protease BACE1 cleaves its membrane-anchored precursor protein.

19 Jul 2018

Protein complex that helps shape destiny of developing T cells identified

Like a mentor helping medical students choose between specialties, a protein complex helps shape the destiny of developing T cells, St. Jude Children's Research Hospital scientists have reported.

9 Jul 2018

Unusual cell-to-cell communication in glioblastoma promotes aggressiveness and therapy resistance

A surprising form of cell-to-cell communication in glioblastoma promotes global changes in recipient cells, including aggressiveness, motility, and resistance to radiation or chemotherapy.

22 Jun 2018

Researchers use 'multiomics' approach to study newborn mouse heart

During the first days of life, the heart of a newborn mouse adapts to entirely new physiological conditions, larger volume loads and an increased energy demand. As a result, fundamental changes occur in the heart. Studies have shown that the heart of neonate mouse retains its ability to effectively repair tissue damage.

4 Jun 2018