Heart Failure News and Research

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Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest or myocardial infarction.

Geron scientists highlight importance of telomerase inhibitor, GRN163L at AACR 2010

Geron Corporation today announced five presentations by Geron scientists and collaborators on the company's telomerase inhibitor, imetelstat sodium, including the drug's activity against cancer stem cells, at the 101st American Association for Cancer Research annual meeting held in Washington D.C.

23 Apr 2010

Nile Therapeutics prices underwritten public offering of common stock

Nile Therapeutics, Inc., a company focused on the development of novel therapeutics for heart failure patients, announced the pricing of its previously announced underwritten public offering of 6,500,000 units of its securities at a public offering price of $0.70 per unit. Each unit consists of one share of Nile common stock and 0.30 warrants to purchase common stock.

23 Apr 2010

Genentech submits sBLA for Herceptin plus chemotherapy for advanced HER2-positive stomach cancer

Genentech, Inc., a wholly owned member of the Roche Group, announced today that the company submitted a supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration (FDA) for Herceptin® (trastuzumab) plus chemotherapy in people with advanced, HER2-positive adenocarcinoma of the stomach, including gastroesophageal junction cancer.

23 Apr 2010

Pfizer announces discontinuation of SUN 1170 Phase 3 study of Sutent in HCC

Pfizer Inc. announced today the discontinuation of the SUN 1170 Phase 3 open-label study of Sutent(r) (sunitinib malate) in advanced hepatocellular carcinoma, or liver cancer. Following a review by the independent Data Monitoring Committee, the study was discontinued based on a higher incidence of serious adverse events in the sunitinib arm compared to the sorafenib arm and the fact that sunitinib did not meet the criteria to demonstrate that it was either superior or non-inferior to sorafenib in the survival of patients with advanced hepatocellular cancer.

23 Apr 2010

Women and men experience different outcomes at U.S. hospitals: HealthGrades

Women and men experience different outcomes at U.S. hospitals for the same procedures and treatments, according to a new study released today by HealthGrades, the leading independent healthcare ratings organization.

22 Apr 2010

"Destination therapy" for end-stage heart failure patients

Federal approval for an alternative therapy to heart transplantation led to a new lease on life for a UT Southwestern Medical Center patient who suffered from heart failure for nearly a decade.

21 Apr 2010

Systems biologists integrate new genetic framework to help predict adverse drug reactions

In a major step toward predicting adverse drug reactions, systems biologists at Mount Sinai School of Medicine in New York City have integrated genetic, cellular and clinical information to find out why certain medicines can trigger fatal heart arrhythmias.

21 Apr 2010

Acorda Therapeutics to initiate Phase 1 clinical trial of GGF2 for heart failure in mid-2010

Acorda Therapeutics, Inc. today announced plans to initiate a Phase 1 single-dose clinical trial of the Company's compound, Glial Growth Factor 2 (GGF2), in patients with heart failure in mid-2010, based on an IND filed with the U.S. Food and Drug Administration (FDA) on March 19, 2010. GGF2 has been shown to protect heart muscle and restore cardiac function in preclinical models of heart failure, myocardial infarction and cardiotoxicity.

20 Apr 2010

End-of-life care documentation helps in emergency treatment decisions

When Heather Rubesch was a teenager, her aunt died in need of a kidney transplant. In later family discussions, Heather's mother, Linda, expressed some of her views about end-of-life care—for instance, her belief in organ donation.

19 Apr 2010

Heart transplant patient skis to the North Pole

They made it! In what is believed to be a world-first, a heart transplant patient along with his transplant doctor skied over 100 miles, over ice, snow drifts, across open water, through gale-force winds and freezing temperatures to make it to the North Pole early Thursday morning.

17 Apr 2010

Research roundup: Revamping NCI Clinical Trials, reducing malpractice suits, health disparities persist

A National Cancer Clinical Trials System For The 21st Century: Reinvigorating The NCI Cooperative Group Program - The "system for conducting cancer clinical trials in the United States is approaching a state of crisis," according to this report on inefficiencies and funding issues faced by the NCI's Clinical Trials Cooperative Group Program - which comprises 10 groups, more than 3,100 institutions, 14,000 investigators and more than 25,000 patients in clinical trials each year.

17 Apr 2010

Researchers study effectiveness of TeleCare in keeping individuals healthy

Like the bleeps of an alarm clock, TeleCare, a home monitoring device, gives the chronically ill a wake-up call: "It's time to take your vitals."

17 Apr 2010

Results of study comparing REMICADE to azathioprine for Crohn's disease published

Findings published today in The New England Journal of Medicine from a first-of-its-kind comparator trial evaluating the anti-tumor necrosis factor (TNF)-alpha biologic treatment REMICADE (infliximab) in the treatment of moderately to severely active Crohn's disease in patients who were naive to immunomodulator and biologic therapy, showed that a significantly greater proportion of patients receiving REMICADE achieved steroid-free remission and mucosal healing compared with patients receiving azathioprine.

16 Apr 2010

Embryos with two mums to remove the risk of hereditary diseases: new research

New research published in the journal Nature, could pave the way to world’s first genetically modified human baby. The research involves making embryos with genes from one man and two women. There are hundreds or families around the world who are left childless or have serious ill babies because they carry genes for hereditary illnesses. This research may bring hope to such couples. According to scientists on the team, within the next three years these women will be able to avail such techniques. There has been skepticism regarding ethical issues attached to making of “designer babies”.

16 Apr 2010

Watson Laboratories' ANDA for generic Toprol XL tablets receives FDA approval

Watson Pharmaceuticals, Inc., today announced that its subsidiary, Watson Laboratories, Inc. - Florida, has received approval from the United States Food and Drug Administration on its Abbreviated New Drug Application for metoprolol succinate extended-release tablets USP in the 100 and 200 mg strengths, the generic equivalent to AstraZeneca's Toprol XL® tablets.

16 Apr 2010

Regulus Therapeutics' metabolic disease program data presented at Diabetes Keystone Symposium

Regulus Therapeutics Inc. today announced that new data from its metabolic disease program were presented at the "Diabetes" Keystone Symposium held April 12-17 in Whistler, British Columbia. The new pre-clinical research findings showed that therapeutic oligonucleotides targeting microRNA are able to improve insulin resistance and normalize plasma glucose in mouse models of diabetes while having no significant effect on glucose or insulin levels in normal mice.

16 Apr 2010

Ibuprofen demonstrates efficacy over acetaminophen for treatment of pain and fever

Cumberland Pharmaceuticals Inc. today announced results from a meta-analysis comparing the efficacy and safety of ibuprofen and acetaminophen, which was published in the March edition of the peer-reviewed journal The Annals of Pharmacotherapy. The publication notes that in a majority of evaluated studies ibuprofen demonstrated superior efficacy compared to acetaminophen for the treatment of pain and fever, and found no significant safety differences between the drugs.

15 Apr 2010

Successful stem cell therapy performed on CHF patients in Mexico

Bioheart, Inc. announced that treatment with stem cell therapy on two congestive heart failure (CHF) patients was performed successfully at the Hospital Angeles Tijuana, Mexico, through Bioheart's Center of Excellence program with Regenerative Medicine Institute.

15 Apr 2010

$SBUMC adds Toshiba Aquilion ONE \320-detector row CT system with pediatric imaging capabilities$

SBUMC adds Toshiba Aquilion ONE \320-detector row CT system with pediatric imaging capabilities

A new state-of-the art computed tomography (CT) scanner that provides physicians with precise images of internal organs with a single rotation of the gantry is now in operation at Stony Brook University Medical Center (SBUMC), adding to the hospital's advanced scanner technology.

15 Apr 2010

Beckman Coulter awarded new agreement with Premier Purchasing Partners for laboratory systems and supplies

Beckman Coulter, Inc., a leading developer, manufacturer, and marketer of products that simplify, automate, and innovate complex biomedical testing, announced that effective April 1, 2010, it has been awarded a new agreement with Premier Purchasing Partners, the group purchasing unit of Premier, Inc., to provide a full range of core laboratory systems and supplies. Premier is one of the nation's largest healthcare purchasing networks, with more than 2,300 member hospitals and 64,000 additional healthcare sites.

From Beckman Coulter Diagnostics 15 Apr 2010

Heart Failure News and Research

Further Reading

Geron scientists highlight importance of telomerase inhibitor, GRN163L at AACR 2010

Nile Therapeutics prices underwritten public offering of common stock

Genentech submits sBLA for Herceptin plus chemotherapy for advanced HER2-positive stomach cancer

Pfizer announces discontinuation of SUN 1170 Phase 3 study of Sutent in HCC

Women and men experience different outcomes at U.S. hospitals: HealthGrades

"Destination therapy" for end-stage heart failure patients

Systems biologists integrate new genetic framework to help predict adverse drug reactions

Acorda Therapeutics to initiate Phase 1 clinical trial of GGF2 for heart failure in mid-2010

End-of-life care documentation helps in emergency treatment decisions

Heart transplant patient skis to the North Pole

Research roundup: Revamping NCI Clinical Trials, reducing malpractice suits, health disparities persist

Researchers study effectiveness of TeleCare in keeping individuals healthy

Results of study comparing REMICADE to azathioprine for Crohn's disease published

Embryos with two mums to remove the risk of hereditary diseases: new research

Watson Laboratories' ANDA for generic Toprol XL tablets receives FDA approval

Regulus Therapeutics' metabolic disease program data presented at Diabetes Keystone Symposium

Ibuprofen demonstrates efficacy over acetaminophen for treatment of pain and fever

Successful stem cell therapy performed on CHF patients in Mexico

SBUMC adds Toshiba Aquilion ONE \320-detector row CT system with pediatric imaging capabilities

Beckman Coulter awarded new agreement with Premier Purchasing Partners for laboratory systems and supplies

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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