Heart Failure News and Research

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Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest or myocardial infarction.

Alendronate may be associated with irregular heartbeat

Alendronate, a medication used to prevent fractures in women with osteoporosis, may be associated with an increased risk of atrial fibrillation, a type of abnormal heart rhythm, according to a report in the April 28 issue of Archives of Internal Medicine.

28 Apr 2008

UCLA study identifies factors leading to hospital admission for heart failure

Nearly two out of three patients have one or more precipitating factors that may contribute to hospital admissions nationwide for heart failure, according to a new UCLA study. Pneumonia, irregular heart beats, and obstructed blood flow to the heart are the most frequent factors.

28 Apr 2008

Interventions for enhancing medication adherence

Patients often do not take the medicines their doctors prescribe, and a new review of existing research suggests that there is no proven way to get them to follow directions for long periods.

24 Apr 2008

FDA approves Relistor for opioid-induced constipation - helps reduce effects of drugs like morphine on bowel function

The U.S. Food and Drug Administration today approved Relistor (methylnaltrexone bromide) to help restore bowel function in patients with late-stage, advanced illness who are receiving opioids on a continuous basis to help alleviate their pain.

24 Apr 2008

Genentech updates on phase III study of Avastin plus chemo in first-line, advanced, non-squamous, non-small cell lung cancer

Genentech, Inc. has announced an update for the previously reported Roche-sponsored international Phase III clinical study (AVAiL) of Avastin (bevacizumab) in combination with gemcitabine and cisplatin chemotherapy, in patients with advanced, non-squamous, non-small cell lung cancer (NSCLC).

21 Apr 2008

GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure

About 40 percent of African-Americans have a genetic variant that can protect them after heart failure and prolong their lives, according to research conducted at Washington University School of Medicine in St. Louis and collaborating institutions.

20 Apr 2008

A genetic variation mimics effect of heart failure medications - may explain why beta-blockers do not work for all patients

A genetic variation, found predominantly in African Americans, protects some people with heart failure, enabling them to live longer than expected. That's the conclusion of a research team led by investigators at the University of Maryland School of Medicine in Baltimore and the Washington University School of Medicine in St. Louis.

20 Apr 2008

Experimental study on most common form of heart valve disease in Western countries may lead to new treatments

A team of scientists from the University of Montreal and the Montreal Heart Institute Research Centre, led by Dr. Jean-Claude Tardif, has completed an important study that show how a new type of medication can lead to an improvement in the aortic valve narrowing

18 Apr 2008

Herceptin and chemotherapy improves response rates without major adverse effects in HER2 breast cancer

Women with a particularly aggressive form of breast cancer seem to do better if they are treated with a combined anthracycline and taxane chemotherapy regimen before surgery, together with trastuzumab (Herceptin) before and after surgery, according to results from the largest multi-centre trial to investigate this treatment.

18 Apr 2008

Loop diuretics linked to bone loss in older men

Older men who take loop diuretics, commonly prescribed drugs for heart failure and hypertension, appear to have increased rates of hip bone loss than men who are not taking this medication, according to a report in the April 14 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

15 Apr 2008

Statins may help control blood pressure

Researchers in the States say that statins, the popular cholesterol-lowering drugs, may also lower blood pressure.

15 Apr 2008

Carotid stenting shows long-term benefit as alternative to surgery

Carotid artery stenting is an effective option for high risk patients who are not eligible for surgery, according to a long-term study published in this week's New England Journal of Medicine.

11 Apr 2008

Hospitalization linked to increased mortality in heart failure patients

Patients with heart failure are at increased risk of death if they are hospitalized for worsening heart failure symptoms, according to new research from UAB (University of Alabama at Birmingham).

11 Apr 2008

Sexual dysfunction in postmenopausal women not linked to heart disease

Although sexual dysfunction in some men is predictive of cardiovascular disease, this association has never been examined in women.

10 Apr 2008

Discovery of process behind heart muscle contraction

Researchers from the University of Pittsburgh and the University of Chicago were able to control heart muscle function in a new way after discovering the previously unknown role of two enzymes in heart muscle contraction, as detailed in the April 11 cover story of the Journal of Biological Chemistry.

10 Apr 2008