Helicase News and Research

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Researchers forge new path to combat viruses and cancers with helicase inhibitors

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections-;and, alas, extraordinarily difficult to target with drugs.

9 Mar 2024

Decoding the differences between two vital RNA transport complexes

Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages.

8 Feb 2024

Pangolins' genetic makeup linked to increased coronavirus susceptibility

Research reveals pangolins' vulnerability to coronavirus due to innate immune gene pseudogenization, impacting their antiviral response.

10 Jan 2024

Study unlock secrets of Zika virus's multipurpose enzyme and reveals therapeutic vulnerability

Viruses have limited genetic material-;and few proteins-;so all the pieces must work extra hard. Zika is a great example; the virus only produces 10 proteins.

8 Dec 2023

Study reveals link between CHD8 gene, gut abnormalities, and autism-related behaviors

The connection between the CHD gene and autism-related gastrointestinal (GI) manifestations.

4 Oct 2023

Researchers unravel structure of MCM8/9 enzyme linked to infertility and cancer

Scientific research requires patience. The rewards are not always immediate, and the technology needed does not always exist. Michael A. Trakselis, Ph.D., professor and director of graduate affairs for the Department of Chemistry and Biochemistry at Baylor University, understands this.

29 Aug 2023

Research shows how mosquito-transmitted viruses hijack host cells to promote infection

New Cleveland Clinic research shows how mosquito-transmitted viruses – like Zika, West Nile, Yellow Fever and dengue viruses – hijack host cells to promote their own replication and infection.

16 Aug 2023

Genetic determinants of retinol circulation and their impact on health

The genetic architecture of circulating retinol.

15 Aug 2023

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

Researchers used a multidisciplinary approach to investigate a nonstructural protein essential in SARS-CoV-2 replication.

10 Aug 2023

Genome-wide study finds link between CHD1L gene and HIV control

"We searched for human genetic variation that associates with spontaneous control of HIV and identified a novel region in the genome that is only variable in populations of African ancestries," says Professor Jacques Fellay at EPFL's School of Life Sciences.

2 Aug 2023

Study finds link between DHX9 gene mutations and neurodevelopmental disorders

A group of 20 patients with undiagnosed neurodevelopmental disorders ranging from severe to mild has now received a genetic diagnosis thanks to an international team of researchers at the GREGoR Research Center at Baylor College of Medicine, the Chinese University of Hong Kong, the German Mouse Clinic and collaborating institutions.

18 Jul 2023

Study sheds light on how viruses override host cell's DNA replication machinery

University of Pittsburgh researchers have shown for the first time how Merkel cell polyomavirus (MCV), which causes an aggressive skin cancer called Merkel cell carcinoma, initiates DNA replication in host cells.

17 Jul 2023

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

Mosaic Therapeutics, an oncology therapeutics company dedicated to resolving cancer’s complexity to power new treatments for patients, today announced the close of its $28 million series A funding round.

From Mosaic Therapeutics 4 Apr 2023

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

Company developing targeted oncology therapies spun out of world-leading research at the Wellcome Sanger Institute, in collaboration with the Netherlands Cancer Institute.

From Mosaic Therapeutics 4 Apr 2023

Comparative study on retinoic acid-inducible gene-I of humans and bats

In a recent study posted to the bioRxiv* preprint server, researchers cloned and functionally characterized the virus ribonucleic acid (RNA) sensor, retinoic acid-inducible gene-I (RIG-I), from the microbat Myotis daubentonii (Yangochiroptera suborder) and the megabat Rousettus aegyptiacus (Yinpterochiroptera suborder), and compared them to the human ortholog.

15 Feb 2023

Study uncovers protein that acts as a brake for DNA replication

A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers.

24 Jan 2023

Study uncovers genetic cause of a novel developmental epilepsy syndrome

Neurodevelopmental disorders (NDD) encompass highly prevalent conditions such as autism and epilepsy, with cognitive disabilities alone affecting 1-3% of the global population.

16 Dec 2022

Detection of filoviruses by the innate immune system

In a new study, researchers examined how the innate immune system detects filoviruses.

1 Dec 2022

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

Researchers presented a functional analysis of the SARS-CoV-2 open reading frame 3c (ORF3c) protein.

17 Nov 2022

Specific mutations in the monkeypox virus contribute to its continued infectiousness

Monkeypox has infected more than 77,000 people in more than 100 countries worldwide, and -; similar to COVID-19 -; mutations have enabled the virus to grow stronger and smarter, evading antiviral drugs and vaccines in its mission to infect more people.

4 Nov 2022

Helicase News and Research

Researchers forge new path to combat viruses and cancers with helicase inhibitors

Decoding the differences between two vital RNA transport complexes

Pangolins' genetic makeup linked to increased coronavirus susceptibility

Study unlock secrets of Zika virus's multipurpose enzyme and reveals therapeutic vulnerability

Study reveals link between CHD8 gene, gut abnormalities, and autism-related behaviors

Researchers unravel structure of MCM8/9 enzyme linked to infertility and cancer

Research shows how mosquito-transmitted viruses hijack host cells to promote infection

Genetic determinants of retinol circulation and their impact on health

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

Genome-wide study finds link between CHD1L gene and HIV control

Study finds link between DHX9 gene mutations and neurodevelopmental disorders

Study sheds light on how viruses override host cell's DNA replication machinery

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

Mosaic Therapeutics closes $28m series A funding and appoints Brian Gladsden as CEO

Comparative study on retinoic acid-inducible gene-I of humans and bats

Study uncovers protein that acts as a brake for DNA replication

Study uncovers genetic cause of a novel developmental epilepsy syndrome

Detection of filoviruses by the innate immune system

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

Specific mutations in the monkeypox virus contribute to its continued infectiousness

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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