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Infection with SARS-CoV-2 results in antibodies against common colds

A study published in the journal Science Advances uses electron microscopy-based polyclonal epitope mapping (EMPEM) methodology to elucidate the spike epitopes of β-HCoV targeted by preexisting serum antibodies and compares them to the epitopes targeted by antibodies elicited by SARS-CoV-2 infection using electron microscopy-based polyclonal epitope mapping (EMPEM) methodology.

8 May 2022

Study describes ultra-structure of Nipah virus surface glycoprotein

A team of US-based scientists has recently demonstrated the cryo-electron microscopic structure and antigenicity of the attachment glycoprotein of the Nipah virus.

27 Apr 2022

Exploring the oligomerizing behavior of SARS-CoV-2 accessory protein 7b

Researchers tested the hypothesis that severe SARS-CoV-2 accessory protein 7b forms oligomers with ion channel activity in lipid and detergent environments.

23 Mar 2022

Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

Researchers constructed a novel fusion inhibitor−based recombinant protein, referred to as 5−Helix, to block SARS-CoV-2 spike-mediated cell-cell fusion.

17 Mar 2022

New insight into SARS-CoV-2 nsp14 protein opens door to new drugs

In a recent research paper currently available on bioRxiv* preprint server, scientists from the University of Oxford in the United Kingdom and the University of Auckland in New Zealand identified several structural specificities of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may serve as viable starting points for the development and optimization of viral inhibitors against coronavirus disease 2019 (COVID-19) and other future threats.

16 Mar 2022

Study models SARS-CoV-2 M protein monomer and dimer 3D structures

Researchers presented new structural insights about the SARS-CoV-2 membrane protein.

15 Mar 2022

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

Researchers isolated a large panel of broadly neutralizing antibodies from COVID-19 recovered-vaccinated donors.

10 Mar 2022

New DNA test can quickly and accurately identify a range of hard-to-diagnose genetic diseases

A new DNA test, developed by researchers at the Garvan Institute of Medical Research in Sydney and collaborators from Australia, UK and Israel, has been shown to identify a range of hard-to-diagnose neurological and neuromuscular genetic diseases quicker and more-accurately than existing tests.

4 Mar 2022

Triple drug regimen proven effective against non-structural protein-1 of SARS-CoV-2

Researchers evaluated the synergistic activity of drugs acting against non-structural protein 1 of SARS-CoV-2 to decrease the viral infectivity.

2 Mar 2022

Mechanisms leading to Parkinson's disease following SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated the impact of an amyloidogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein fragment named SFYVYSRVK (SK9) on the α-synuclein (aS) monomers and fibrils, a potential risk factor for Parkinson's disease.

28 Feb 2022

MUSC study sheds light on better ways to prevent and treat colorectal cancer

An MUSC Hollings Cancer Center study sheds light on better ways to prevent and treat colorectal cancer, which often is found at advanced stages when it's much harder to treat.

28 Feb 2022

Mechanism of SARS-CoV-2 Nsp1 interaction with ribosomal complexes

In a recent study posted to the bioRxiv* preprint server, the team of researchers explored the protein-protein interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 1 (Nsp1) and host 40S and 43S ribosomal subunits.

15 Feb 2022

RNA capping mechanism of SARS-CoV-2 unveiled

In a recent study posted to the bioRxiv* preprint server, researchers elucidated the mechanism of ribonucleic acid (RNA) capping in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

14 Feb 2022

Deep insights on digital transformation in health care

The COVID-19 pandemic sparked a digital transformation in health care. Artificial intelligence and the Internet of Things are contributing to widespread changes in medicine, as reviewed in a Special Issue on All Things Digital Transformation in the peer-reviewed OMICS: A Journal of Integrative Biology.

14 Feb 2022

Helix News and Research

Infection with SARS-CoV-2 results in antibodies against common colds

Study describes ultra-structure of Nipah virus surface glycoprotein

Exploring the oligomerizing behavior of SARS-CoV-2 accessory protein 7b

Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

New insight into SARS-CoV-2 nsp14 protein opens door to new drugs

Study models SARS-CoV-2 M protein monomer and dimer 3D structures

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

New DNA test can quickly and accurately identify a range of hard-to-diagnose genetic diseases

Triple drug regimen proven effective against non-structural protein-1 of SARS-CoV-2

Mechanisms leading to Parkinson's disease following SARS-CoV-2 infection

MUSC study sheds light on better ways to prevent and treat colorectal cancer

Mechanism of SARS-CoV-2 Nsp1 interaction with ribosomal complexes

RNA capping mechanism of SARS-CoV-2 unveiled

Deep insights on digital transformation in health care

Study describes a β-CoV spike protein target for protective antibodies that may facilitate pan-β-CoV vaccine development

Study reveals that 1PBC and niclosamide bind the same drug-binding pocket

SARS-CoV-2 nucleocapsid G215C variation may explain Delta severity

New method decodes the role of DDX41 protein in preventing double-strand breaks in DNA

Representative structures of SARS-CoV-2 and development of therapeutic agents for targeting these proteins

Exploring beta-coronavirus neutralization by vaccine-induced murine antibody WS6

Innovations in baculovirus–insect cell expression systems

Compound Management and its Crucial Role in Early Pharmaceutical Research

Natural products: the next frontier in drug discovery

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