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SARS-CoV-2 nucleocapsid G215C variation may explain Delta severity

A new study shows that the SARS-CoV-2 nucleocapsid protein has unique properties that allow the virus to become more infective in the presence of certain mutations.

11 Feb 2022

New method decodes the role of DDX41 protein in preventing double-strand breaks in DNA

There are many different ways in which the genetic material DNA can be damaged, resulting in the development of diseases such as cancer. Certain forms of DNA damage are associated with so-called R-loops.

8 Feb 2022

Representative structures of SARS-CoV-2 and development of therapeutic agents for targeting these proteins

Researchers from China summarized the representative structures of SARS-CoV-2 proteins and discussed the development of novel therapeutic agents for targeting these proteins to treat and prevent COVID-19.

2 Feb 2022

Exploring beta-coronavirus neutralization by vaccine-induced murine antibody WS6

In a new study, researchers evaluated the neutralizing antibody titers in mice vaccinated with messenger ribonucleic acid (mRNA) encoding SARS-CoV-2 spike (S) protein.

1 Feb 2022

Researchers use microscopic strands of DNA to assemble hydrogel blocks

Researchers from the Okinawa Institute of Science and Technology Graduate University (OIST) have used microscopic strands of DNA to guide the assembly of gel blocks that are visible to the naked eye.

31 Jan 2022

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

A new paper in the journal Molecules describes this in molecular terms, comparing SARS-CoV-2 with an earlier highly pathogenic coronavirus, SARS-CoV.

31 Jan 2022

COVID-19 vaccines elicit cross-reactive antibodies against endemic coronaviruses

Researchers study the interaction between immunity to endemic coronaviruses and SARS-CoV-2.

30 Jan 2022

UofL professor wins $6.7 million grant to investigate how metals cause lung cancer

For nearly three decades, John Pierce Wise Sr. has investigated the connection between exposure to metals and cancer, working both in the lab and in the field, reporting significant discoveries about the effects of metals on chromosomes in lung cancer and how those effects differ in humans and in whales.

27 Jan 2022

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

In a recent study posted to the bioRxiv* preprint server, researchers evaluated the mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated inflammatory marker interferon (IFN) repression in hosts.

25 Jan 2022

An algorithm to predict host cleavage targets of SARS-CoV-2 3CLPro

In a recent study posted to the bioRxiv* preprint server, researchers developed a novel bioinformatic algorithm to predict host cleavage targets of the SARS-CoV-2 3C-like protease (3CLPro).

23 Jan 2022

Genetic marker linked to higher risk of death in COVID-19 patients

A new study discusses the importance of single nucleotide polymorphisms in the Rab46 gene as a marker of adverse outcomes in high-risk COVID-19 patients.

23 Jan 2022

Flexibility may maximize the potency of peptides used to treat Type 2 diabetes

A little wiggle room might be just what the doctor ordered. New research suggests that the peptides -; short chunks of protein -; used to treat Type 2 diabetes may be more effective if they're able to flexibly move back and forth between different shapes.

23 Dec 2021

Helix News and Research

SARS-CoV-2 nucleocapsid G215C variation may explain Delta severity

New method decodes the role of DDX41 protein in preventing double-strand breaks in DNA

Representative structures of SARS-CoV-2 and development of therapeutic agents for targeting these proteins

Exploring beta-coronavirus neutralization by vaccine-induced murine antibody WS6

Researchers use microscopic strands of DNA to assemble hydrogel blocks

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

COVID-19 vaccines elicit cross-reactive antibodies against endemic coronaviruses

UofL professor wins $6.7 million grant to investigate how metals cause lung cancer

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

An algorithm to predict host cleavage targets of SARS-CoV-2 3CLPro

Genetic marker linked to higher risk of death in COVID-19 patients

Flexibility may maximize the potency of peptides used to treat Type 2 diabetes

QTQTN motif upstream of furin-cleavage site in SARS-CoV-2 infection and pathogenesis

Comparison of RBD/ACE2 receptor complex in wild type SARS-CoV-2 and Omicron variant

Study demonstrates SARS-CoV-2 ORF6 localization and interferon antagonism as independent events

Effect of mutations on SARS-CoV-2 E protein interactions with cell junctions

SARS-CoV-2 antibody profiles in vaccinated and convalescent macaques compared to humans

ORF10 protein mutations alter SARS-CoV-2 pathogenicity

Impact of engineered ACE2-Fc on SARS-CoV-2 infection

Error rate of bacterial DNA polymerase is consistently higher under microgravity, study shows

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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