High Throughput News and Research

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Nanoneedle technology licensed for early detection of disease, biomarker discovery

A Boston-based startup company, NanoMosaic LLC, intends to commercialize a high-throughput, high-sensitivity platform for analyte detection developed at Harvard University.

2 Apr 2020

Biogazelle initiates large-scale testing of patient samples for SARS-CoV-2

Biogazelle NV, a CRO specialized in RNA analytics, has announced the initiation of large-scale testing of patient samples for SARS-CoV-2. Biogazelle is providing one of the multiple testing sites in a government-led consortium of pharma, biotech, IT and academia, alongside Janssen Pharmaceutica (J&J), GSK, UCB, UgenTec, MIPS and ThermoFisher.

2 Apr 2020

Researchers develop new PCR system for detection of SARS-CoV-2 virus

Michael Traugott and the spin-off company Sinsoma GmbH, together with the Departments of Zoology and Microbiology at the University of Innsbruck, are developing a new PCR system for the detection of the SARS-CoV-2 virus.

1 Apr 2020

Virus-scanning tool could identify previously undetected cases of COVID-19 infections

When a virus invades the body, it leaves fingerprints behind. A research tool known as VirScan can detect this evidence - from just a single drop of blood - and identify the viruses that have infected a person in the past. Soon, the new coronavirus will join the VirScan lineup.

31 Mar 2020

New microfluidic chip can mimic hypoxic conditions after a heart attack

Researchers led by biomedical engineers at Tufts University invented a microfluidic chip containing cardiac cells that is capable of mimicking hypoxic conditions following a heart attack - specifically when an artery is blocked in the heart and then unblocked after treatment.

30 Mar 2020

Why Primary Cells Are Important for In Vitro ADME-Tox Studies

Lonza is a large, multinational corporation serving the entire pharmaceutical product development and manufacturing pipeline, from non-clinical research products to final dosage and delivery solutions.

From Lonza 26 Mar 2020

Russian researchers explain why new pathogenic viruses are so hard to detect

In a recently published fundamental review dedicated to the diagnostics of viral infections, a Russian research team featuring MIPT researchers was the first to systematically describe and summarize the cutting-edge technologies in the rapidly developing field of genetics.

25 Mar 2020

MILabs enhances preclinical diagnostic U-CT system for COVID-19 research

Based on recent scientific research, diagnostic X-ray CT is able to detect COVID-19, the disease caused by the novel coronavirus (SARS-CoV-2), in individuals with high clinical suspicion of the virus -- even in cases with negative initial DNA tests.

20 Mar 2020

Researches develop a new method of scanning probe microscopy controlled by AI

A team have established a method of fully autonomous scanning probe microscopy (SPM) controlled by artificial intelligence.

19 Mar 2020

High-throughput screening of AAV vector capsid libraries reveals unexpected insights

Researchers have used high-throughput screening of adeno-associated viral (AAV) vector capsid libraries to maximize the likelihood of obtaining AAV variants with desired properties.

18 Mar 2020

Tooth-enamel protein discovered in the eyes of people with dry AMD

A protein that normally deposits mineralized calcium in tooth enamel may also be responsible for calcium deposits in the back of the eye in people with dry age-related macular degeneration, according to a study from researchers at the National Eye Institute.

13 Mar 2020

New NGS technique offers quick, accurate diagnosis of sepsis

A report in the Journal of Molecular Diagnostics, published by Elsevier, describes a new technique that uses real-time next-generation sequencing to analyze tiny amounts of microbial cell-free DNA in the plasma of patients with sepsis, offering the possibility of accurate diagnosis of sepsis-causing agents within a few hours of drawing blood.

5 Mar 2020

New collapsible basket technology has big advantages for drug discovery, personalized medicine

A drug discovery scientist typically screens up to 10,000 compounds in the early stages of developing one FDA approved drug. During this high-throughput screening, candidate compounds are initially tested on cell and tissue samples.

4 Mar 2020

Novel drug to arrest antibiotic resistance by preventing micro-evolution

Desperate times need desperate measures. Accordingly, scientists, today published a new study in the journal Cell Host and Microbe in March 2020, showing that drugs that prevent the acquisition of DNA-borne antibiotic resistance traits from their surroundings by bacteria can stop mice from becoming resistant to the action of the antibiotics.

3 Mar 2020

New method maps 3D forces exerted by tiny cell clusters

A team of researchers has developed a new technique to map the three-dimensional forces that clusters of human cells exert on their surrounding environment. The method could potentially help scientists better understand how tissue forms, how wounds heal or how tumors spread.

3 Mar 2020

Challenges for translating pharmacomicrobiomics to personalized medicine

A new Commentary identifies three actionable challenges for translating pharmacomicrobiomics to personalized medicine in 2020.

2 Mar 2020

New research cluster aims to use mass spectrometry to provide insights in systems medicine

The Mainz University Medical Center and Johannes Gutenberg University Mainz are establishing the interdisciplinary research cluster entitled "Data-Independent Acquisition-based Systems Medicine (DIASyM): Mass Spectrometry for High-Throughput Deep Phenotyping of Heart Failure Syndrome".

28 Feb 2020

Cultural transition to agriculture linked with emergence of human-adapted pathogens

Using Salmonella enterica genomes recovered from human skeletons as old as 6,500 years, an international team of researchers illustrates the evolution of a human pathogen and provides the first ancient DNA evidence in support of the hypothesis that the cultural transition from foraging to farming facilitated the emergence of human-adapted pathogens that persist until today.

25 Feb 2020

Sartorius launches BioPAT Spectro for use with ambr systems and BIOSTAT STR

Sartorius, a leading international partner of the biopharmaceutical industry today introduced BioPAT Spectro, a Quality by Design tool for use with its ambr automated micro and mini bioreactor systems and with the single-use production bioreactors BIOSTAT STR.

From Sartorius 24 Feb 2020

Essential oil components could meet the criteria set for drug candidates

A research team at the VIB-KU Leuven Center for Microbiology and the KU Leuven Department of Biology showed that, contrary to generally held belief, most components of essential oils could meet the criteria set for drug candidates.

23 Feb 2020