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DNA must be enormously compressed in sperm cells, study says

If you are moaning once again about your suitcase being far too small as your vacation approaches, you should take human sperm cells as an inspiration.

11 Jul 2022

New study investigates the epigenetic drift of time passing

A new research paper was published in Aging (Aging-US) on the cover of Volume 14, Issue 12, entitled, "Time makes histone H3 modifications drift in mouse liver."

30 Jun 2022

Study finds SARS-CoV-2 E protein antagonizes BET protein-mediated antiviral responses during infection

Researchers assessed the impact of SARS-CoV-2 envelope protein on the bromodomain and extraterminal domain (BET) proteins.

29 Jun 2022

International researchers win funding for Cancer Grand Challenge

Pediatric oncologist Anton Henssen and a group of researchers from the US and the UK have won funding for a Cancer Grand Challenge.

16 Jun 2022

Study brings precision medicine closer to reality for diffuse large B cell lymphoma

DNA mutations are essential to the rapid development of an array of antibody-producing immune cells called B cells that collectively can recognize a vast number of specific targets.

25 May 2022

Researchers discover potential treatment approach for advanced uveal melanoma

An international team of researchers led by University College Dublin (UCD) have uncovered a potential treatment approach for advanced uveal melanoma (UM), a type of cancer that effects the eye.

19 May 2022

Multi-omics identify COVID-19 severity predictors and prothrombotic signatures in patients with end-stage kidney disease

Researchers demonstrated that plasma levels of leucine-rich repeat-containing 15 are a strong indicator of the severity of COVID-19 in patients with end-stage kidney disease.

3 May 2022

CRISPR/Cas9 deletions induce adverse on-target genomic effects

Researchers utilized a CRISPR/Cas9 system to evaluate the usage of tRNA by deleting two tRNA genes from the genomes of hyper hepatocellular carcinoma and human near-haploid chronic myeloid leukemia cells.

27 Apr 2022

Effect of COVID-19 mRNA vaccine on in vitro glial cells of the brain studied by Raman spectroscopy and imaging

Researchers studied how the mRNA-based BNT162b2 COVID-19 vaccine altered the biochemical composition of glial and glioma brain cells in vitro.

8 Mar 2022

New technique can upregulate specific genes without permanently altering the genome

By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical "off switches" that silence them.

6 Mar 2022

Study reveals role of a protein in healthy functioning of blood stem cells

A protein that masterminds the way DNA is wrapped within chromosomes has a major role in the healthy functioning of blood stem cells, which produce all blood cells in the body, according to a new study from researchers at Weill Cornell Medicine.

28 Jan 2022

ANU researchers identify why Th17 cells go rogue and promote the onset of multiple sclerosis

Researchers from The Australian National University (ANU) have identified why certain cells in the body, known as Th17 cells, go rogue and promote the onset of autoimmune diseases such as multiple sclerosis (MS).

27 Jan 2022

UBR7 protein acts as a histone chaperone during DNA replication, study finds

The protein UBR7 acts as a histone chaperone, regulating histone re-deposition at specific sites during DNA replication, according a recent study published in The EMBO Journal.

20 Dec 2021

Mutations in histone regulator protein linked to rare neurodevelopmental disorder, cancers

Mutations in a histone regulator protein are linked to both a rare neurodevelopmental disorder and to some cancers, according to a study published in the journal Genes and Development.

16 Dec 2021

Hypercoagulability of the blood responsible for cardiac thrombosis in COVID-19 patients

Researchers examined autopsy tissue samples of hearts from patients who died early in the COVID-19 pandemic.

7 Dec 2021

The antiviral function of BET protein against SARS-CoV-2 infection

Considering the past shreds of evidence on BRD2 and BRD4 associated with viral infections, researchers have recently evaluated the function of all relevant BET proteins during COVID-19 infection.

17 Nov 2021

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

A recent study investigates histone mimicry as a mechanism by SARS-CoV-2 for disrupting epigenetic regulation to evade host cell responses to infection.

15 Nov 2021

Scientists develop a single-cell chromatin atlas for the human genome

Researchers at University of California San Diego have produced a single-cell chromatin atlas for the human genome.

14 Nov 2021

Two proteins work in tandem to build lifelines to cancer cells, study finds

In human cancer cell and mouse studies, researchers from Johns Hopkins Medicine have found that a set of proteins work in tandem to build supply lines that deliver oxygen and nutrients to tumors, enabling them to survive and grow.

20 Sep 2021

Fountain of youth for the epigenome could become important in the treatment of osteoporosis

As we age, our bones become thinner, we suffer fractures more often, and bone-diseases such as osteoporosis are more likely to occur. One responsible mechanism involves the impaired function of the bone-marrow stem cells, which are required for the maintenance of bone integrity.

15 Sep 2021