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New C. elegans model will accelerate study of a rare disease

The model will permit to accelerate and reduce the price of the research, which is studying the mechanisms and the possible pharmacological targets for the neuronal alterations of this disease.

20 Feb 2020

UT Southwestern scientists discover potential vulnerabilities in new coronavirus

UT Southwestern Medical Center data scientists analyzing genetic sequences of the COVID-19 coronavirus have identified potential vulnerabilities that could help in vaccine development and further study of the infectious disease now spreading worldwide.

17 Feb 2020

Generating genomes and encoding new abilities into artificial DNA

A new study to be presented at the American Association for the Advancement of Science (AAAS) in February 2020 will report on the generation of the world’s first artificially created bacterial genome using a digital design algorithm along with the synthesis of DNA building blocks on a large scale. This genome takes form by chemical rather than template-based synthesis. The research is published in the journal Proceedings of the National Academy of Sciences.

16 Feb 2020

DNA misfolding linked to heightened risk for Type 1 diabetes

It's known that genetics, or an inherited genome, is a major determinant of one's risk for autoimmune diseases, like Type 1 diabetes. In human cells, a person's genome--about six feet of DNA--is compressed into the micrometer space of the nucleus via a three-dimensional folding process.

11 Feb 2020

Scientists reveal the damaging effect of Zika virus on a type of brain cell

The Zika virus (ZIKV) outbreak in Brazil in 2015 sparked for many health agencies and scientists to study the pathogen, which has been linked to microcephaly and other fetal neurological disorders collectively known as Congenital Zika Syndrome.

27 Jan 2020

Research unravels consequences of Zika virus attack on neural cells

Previous studies regarding the damage of the Zika virus on the brain had already pointed out the virus's predilection for a certain neural cell: the astrocyte. However, few studies have proposed to identify the infection effects on these cells, as well as their association with developmental alterations, including brain malformations and microcephaly.

27 Jan 2020

Study provides key insights on potential origins of coronavirus outbreak in China

Emerging viral infections--from bird flu to Ebola to Zika infections--pose major threats to global public health, and understanding their origins can help investigators design defensive strategies against future outbreaks.

22 Jan 2020

New sensitive marker may enable early diagnosis, treatment of spotted fever rickettsioses

Rickettsiae are bacteria that cause severe, potentially lethal human infections, including Mediterranean spotted fever and Rocky Mountain spotted fever.

16 Jan 2020

Tackling antibiotic resistance head-on with CRISPR

With modern advances in genetic engineering occurring almost every day, the latest discovery concerns antibiotic resistance. Using the powerful gene editor CRISPR, scientists reported the development of a gene-drive system that is 100 times as efficient as other current systems at inactivating a specific bacterial gene responsible for making the bacterium antibiotic-resistant and which is present as multiple copies within the same bacterial cell.

16 Dec 2019

Mutated version of DNA repair protein may illuminate its role in preventing cancer

Two trillion times each day, the cells in a typical human divide to replace old, damaged or dead cells. Before a cell divides, though, it makes an exact copy of its DNA, which will be passed on to the new cells.

31 Oct 2019

Researchers uncover novel molecular clues for tumor aggression in neurofibromatosis type 1

Researchers at the Johns Hopkins Kimmel Cancer Center report that their study of tumor samples from people with the rare genetic syndrome neurofibromatosis type 1 (NF1) has uncovered novel molecular clues about which tumors are most likely to be aggressive in those with NF1

From Johns Hopkins Medicine 18 Oct 2019

Rotavirus plays role in development of type 1 diabetes

A new article published in the journal PLOS Pathogens on October 10, 2019, claims that the common rotavirus may be responsible for the occurrence of type 1 diabetes, a form of diabetes which occurs in children and is due to destruction of the pancreatic islet cells that produce the hormone insulin to normalize blood glucose levels.

13 Oct 2019

Intensive new combination therapy for ovarian cancer shows promising results

Researchers have found that more intensive chemotherapy maintenance for ovarian cancer could be beneficial for patients. The results of the study were presented at the ESMO Congress 2019 in Barcelona, Spain last weekend on the 28th of September.

30 Sep 2019

Novel therapeutic approach improves survival in patients newly diagnosed with advanced ovarian cancer

An international study demonstrates that administering niraparib after conventional chemotherapy treatment in patients newly diagnosed with advanced ovarian cancer, improves their progression-free survival, and reduces their risk of relapse or death from this disease.

28 Sep 2019

PARP inhibitor combined with chemotherapy increases survival for newly diagnosed ovarian cancer patients

Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that initial treatment with the PARP inhibitor veliparib in combination with chemotherapy significantly increased progression-free survival for patients with newly diagnosed, metastatic high-grade serous ovarian cancer, according to the results of the VELIA trial.

28 Sep 2019

Research explains why many psychiatric drugs that work in the lab don’t work in people

Current drug development for neuropsychiatric disorders is in crisis, say experts. More than 90 percent of all drugs that are developed for illnesses like schizophrenia, depression, Alzheimer’s disease (AD), or the brain tumor glioblastoma complete successful trials in mice but then come to a grinding halt in human trials, wasting billions of dollars in drug research. This is partly because of obvious behavioral differences between the two species.

22 Aug 2019

Homologous News and Research

New C. elegans model will accelerate study of a rare disease

UT Southwestern scientists discover potential vulnerabilities in new coronavirus

Generating genomes and encoding new abilities into artificial DNA

DNA misfolding linked to heightened risk for Type 1 diabetes

Scientists reveal the damaging effect of Zika virus on a type of brain cell

Research unravels consequences of Zika virus attack on neural cells

Study provides key insights on potential origins of coronavirus outbreak in China

New sensitive marker may enable early diagnosis, treatment of spotted fever rickettsioses

Tackling antibiotic resistance head-on with CRISPR

Mutated version of DNA repair protein may illuminate its role in preventing cancer

Researchers uncover novel molecular clues for tumor aggression in neurofibromatosis type 1

Rotavirus plays role in development of type 1 diabetes

Intensive new combination therapy for ovarian cancer shows promising results

Novel therapeutic approach improves survival in patients newly diagnosed with advanced ovarian cancer

PARP inhibitor combined with chemotherapy increases survival for newly diagnosed ovarian cancer patients

Research explains why many psychiatric drugs that work in the lab don’t work in people

Neuronal gene mutations may be linked to seizures associated with Long QT Syndrome

FDA announces new policy framework for development of regenerative medicine products

Study shows promise for a drug to extend life of patients with ovarian cancer

Researchers unlock mystery of immunosuppressive drug's biosynthesis

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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