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Bifunctional nanobodies with antitoxin potencies could protect against botulinum neurotoxins

New study reveals potential for developing novel antibody-based antitoxins against botulinum neurotoxins (BoNTs), including the most commonly used, yet most toxic one, Botox.

27 Feb 2020

Heroin use increasing among American adults

Earlier studies have shown a startling sevenfold increase in illnesses and deaths directly traceable to heroin use in the USA over less than 20 years. Along with this epidemic, HIV and hepatitis infections acquired by injections of drugs have also broken out in large clusters in many places. Yet, the extent of heroin use itself has been neglected. The current study looked at this overlooked area of research.

11 Feb 2020

Advanced X-ray combination technique aids tuberculosis and osteoporosis research

With an advanced X-ray combination technique, scientists have traced nanocarriers for tuberculosis drugs within cells with very high precision.

4 Feb 2020

Nanoparticle Trojan horse approach to clearing atherosclerotic plaques

Researchers from Michigan State University and Stanford University have designed special nanoparticles which could break down an atherosclerotic plaque from within. This could prevent heart attacks say researchers. The study titled, “Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis,” was published in the latest issue of the journal Nature Nanotechnology.

29 Jan 2020

Novel nanoparticle eats away portions of plaques that cause heart attacks

Michigan State University and Stanford University scientists have invented a nanoparticle that eats away - from the inside out - portions of plaques that cause heart attacks.

27 Jan 2020

Horseback riding along with brain-building tasks can benefit children with neurodevelopmental disorders

Therapeutic horseback riding combined with brain-building exercises can improve the dexterity, coordination and strength of children with neurodevelopmental disorders, shows a study in Frontiers in Veterinary Science.

24 Jan 2020

Researcher wins $2.5 million grant to study why therapeutic horseback riding benefits autistic children

After showing that a 10-week therapeutic horseback riding intervention reduced irritability and hyperactivity while improving the social communication skills of youth diagnosed with autism spectrum disorder, University of Colorado Anschutz Medical Campus researcher and Children's Hospital Colorado psychologist, Dr. Robin Gabriels, has received a $2.5 million grant to investigate why the therapy works.

22 Jan 2020

Scientists break new ground with animal-free antibodies for diphtheria

A project taking the first steps towards ending the use of horses to treat diphtheria has succeeded.

21 Jan 2020

Sodium chloride nanoparticles offer potential for cancer therapies with fewer side effects

A new study at the University of Georgia has found a way to attack cancer cells that is potentially less harmful to the patient. Sodium chloride nanoparticles – more commonly known as salt – are toxic to cancer cells and offer the potential for therapies that have fewer negative side effects than current treatments.

9 Jan 2020

Inputs to the motor cortex can guide dexterous movements in mice

In a sleepy haze, reaching out and grabbing the coffee cup in front of you seems to happen on autopilot. But your caffeine-deprived brain is working hard.

26 Dec 2019

Using bacterial nano-syringes as drug transporters in medicine

Pathogens can use a range of toxins to damage their host organism. Bacteria, such as those responsible for causing the deadly Plague, use a special injection mechanism to deliver their poisonous contents into the host cell.

17 Dec 2019

Some phages employ new strategy to avoid becoming the next casualty of DNA-dicing enzymes

Bacteria and the viruses that infect them are engaged in a molecular arms race as ancient as life itself. Evolution has equipped bacteria with an arsenal of immune enzymes, including CRISPR-Cas systems, that target and destroy viral DNA. But bacteria-killing viruses, also known as phages, have devised their own tools to help them outmaneuver even the most formidable of these bacterial defenses.

9 Dec 2019

Common cold virus could infect fetus via placenta

According to researchers, the common cold viruses are capable of infecting human placental cells and may thus transmit the infection to the fetus in the womb during pregnancy. The new study was published in the journal PLOS ONE, and provides the first concrete proof that this type of carriage is possible.

3 Dec 2019

HIV positive sperm bank launched in New Zealand

In pursuit of greater acceptance for HIV positive people, an organization in New Zealand aspires to begin an HIV positive sperm bank called Sperm Positive. It will start by accepting sperms from 3 males who have HIV but are being treated such that their sperm is not capable of transmitting the infection at present. The treatment has reduced viremia (the viral load in the blood) to such a level that it is undetectable by standard methods.

27 Nov 2019

Giving a shot of ketamine could help heavy drinkers reduce alcohol intake

A one-off dose of ketamine could help heavy drinkers reduce their alcohol intake, finds a new UCL experimental study.

26 Nov 2019

Celiac disease may now be curable with biodegradable nanoparticles

A phase 2 trial just concluded shows that people with celiac disease may now be able to hope for a cure, through a treatment that makes the immune system tolerant towards gluten. This could eventually make it possible for such individuals to eat gluten-containing foods without fear.

22 Oct 2019

New treatment shows promise to reverse celiac disease

Results of a new phase 2 clinical trial using technology developed at Northwestern Medicine show it is possible to induce immune tolerance to gluten in individuals with celiac disease. The findings may pave the way for treated celiac patients to eventually tolerate gluten in their diet.

22 Oct 2019

β-blockers could regenerate infant heart muscle, mitigate effects of congenital heart disease

Surgery can mend congenital heart defects shortly after birth, but those babies will carry a higher risk of heart failure throughout the rest of their lives. Yet, according to a Science Translational Medicine study published today by UPMC Children's Hospital of Pittsburgh researchers, β-blockers could supplement surgery to regenerate infant heart muscle and mitigate the lasting effects of congenital heart disease.

9 Oct 2019

UCLA researchers identify new drug delivery pathway to stop tumor growth

Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new drug delivery pathway that may help stop tumor growth and keep cancer from coming back in mice.

25 Sep 2019

Using 'Trojan horse' strategy to kill deadly antibiotic-resistant pathogens

Pseudomonas aeruginosa is a dangerous bacterium that causes infections in hospital settings and in people with weakened immune systems.

24 Sep 2019