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Lab-grown brain organoids may hold the answers to personalized treatments for glioblastomas

Lab-grown brain organoids developed from a patient's own glioblastoma, the most aggressive and common form of brain cancer, may hold the answers on how to best treat it.

26 Dec 2019

Leukemia patients treated with common cancer drug have heightened risk of heart failure

Patients with acute lymphoblastic leukemia or acute myeloid leukemia who are treated with anthracyclines are at a heightened risk of heart failure- most often within one year of exposure to the chemotherapy treatment, according to a new study led by researchers at Penn Medicine.

17 Dec 2019

New combination therapy can lead to durable responses in patients with multiple myeloma

An experimental, off-the-shelf immunotherapy that combines a targeted antibody and chemotherapy can lead to potentially durable responses in multiple myeloma patients whose disease has relapsed or is resistant to other standard therapies.

17 Dec 2019

Penn researchers track defective sperm epigenome linked to male infertility

One out of eight couples has trouble conceiving, with nearly a quarter of those cases caused by unexplained male infertility. For the past decade, research has linked that infertility to defective sperm that fail to "evict" proteins called histones from DNA during development.

16 Dec 2019

UAB seminar on the extraordinary science of the immune system

"The human immune system makes my head explode," Pulitzer Prize-winning journalist Matt Richtel recently told a University of Alabama at Birmingham freshman seminar on immunology. "This is by far the hardest subject I have ever had to explore."

15 Dec 2019

Community-based program enables donation of tumor tissue and blood samples for research

Precision medicine with targeted therapies has led to improved treatment options and patient outcomes. These approaches were developed by studying tumors grown in laboratories and patient samples obtained before and during their treatment.

14 Dec 2019

The health care promises we cannot keep

It was a promise Matt Perrin wasn't able to keep. "I'll never take away your independence," he'd told his mother, Rosemary, then 71, who lived alone on Cape Cod, Mass., in a much-loved cottage.

12 Dec 2019

Genetic variant mainly found in individuals of African ancestry increases odds of heart failure

A genetic variant in the gene transthyretin (TTR)- which is found in about 3 percent of individuals of African ancestry- is a more significant cause of heart failure than previously believed, according to a multi-institution study led by researchers at Penn Medicine.

10 Dec 2019

Common antibiotic appears to boost the effect of radiation on tumor cells

The antibiotic vancomycin alters the gut microbiome in a way that can help prime the immune system to more effectively attack tumor cells after radiation therapy.

9 Dec 2019

Yale study highlights the need to develop effective, less toxic approaches to treat AML patients

A new study by Yale Cancer Center researchers shows understanding treatment patterns for patients with acute myeloid leukemia is vital to develop strategies to improve outcomes.

9 Dec 2019

$Experimental immunotherapy can put patients with relapsed or refractory lymphoma into remission$

Experimental immunotherapy can put patients with relapsed or refractory lymphoma into remission

A new, experimental immunotherapy can put patients with B-cell non-Hodgkin lymphoma (NHL) that is resistant to or has come back after multiple other therapies, including CAR T therapy, into remission.

8 Dec 2019

Broadly expressed metabolic approach could make sarcoma susceptible to targeted therapies

Soft tissue sarcoma cells stop a key metabolic process which allows them to multiply and spread, and so restarting that process could leave these cancers vulnerable to a variety of treatments.

26 Nov 2019

Researchers analyze online review content of specialized drug treatment facilities

Almost 10 percent of the nation's entire population live with substance use disorder, but many struggle to find the right help – a task which is made more difficult because there is no standardized rating system to ensure the quality of care within specialized drug treatment facilities.

22 Nov 2019

Atlantic Health System offers advanced lung cancer screening program

November is national Lung Cancer Awareness Month. Lung cancer remains the #1 cancer killer of both men and women in the United States.

20 Nov 2019

Counties experiencing most economic distress have highest heart disease mortality rates

Communities in the United States that experienced the most economic distress in the wake of the Great Recession saw a significant increase in death rates from heart disease and strokes among middle-aged people, according to a new multi-institution study led by researchers at Penn Medicine.

18 Nov 2019

Early diagnosis of peripartum cardiomyopathy associated with improved outcomes

Women who are diagnosed with peripartum cardiomyopathy (PPCM) during late pregnancy or within a month following delivery are more likely to experience restored cardiac function and improved outcomes compared to those who are diagnosed later in the postpartum period, according to a new study from Penn Medicine.

17 Nov 2019

Eradicating H pylori infection significantly reduces gastric cancer risk

While it is well known within the medical community that there is a link between the bacteria Helicobacter pylori (H pylori) and rates of gastric cancer- commonly referred to as stomach cancer-;the rates and risk among Americans has been largely understudied.

14 Nov 2019