Human Leukocyte Antigen News and Research

RSS

Third BNT162b2 dose effectively neutralizes SARS-CoV-2 Omicron pseudovirus

The findings reveal that the Omicron neutralizing titers induced by the third vaccine dose are comparable to that achieved against the original Wuhan strain (wild-type SARS-CoV-2) by the two-dose regimen. The study is currently available on the medRxiv* preprint server while awaiting peer review.

28 Dec 2021

Investigating potential cross-protection against SARS-CoV-2 after previous exposure to bovine coronavirus

Researchers have conducted an investigation to probe the similarity of viral epitopes between bovine coronavirus (BCoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Dec 2021

T cell responses remain broadly robust against Omicron variant of SARS-CoV-2

A new study highlights the significance of robust T cell responses in preventing severe omicron infections.

16 Dec 2021

COVID-19 in association with pre-existing mental and physical health issues

The present study attempts to identify the factors that increase the risk of COVID-19 infection or confer protection against COVID-19 in a study population above 55 years of age known to experience higher morbidity and risk of mortality from COVID-19.

13 Dec 2021

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

A new study, published on the bioRxiv* preprint server, has focused on public clonotypes, i.e., clones found in multiple individuals, for the development of a novel reverse epitope discovery technique. This technique holds greater potential for population-wide applications.

23 Nov 2021

What are the anti-COVID drugs currently in development?

The first antiviral drugs effective against COVID-19 were recently approved in the UK and USA. A researcher from the Laboratory of Gene Technology has been exploring what we know so far.

8 Nov 2021

Study assesses T-cell responses directed against highly conserved regions of SARS-CoV-2

The study aimed to assess whether highly conserved regions within coronaviruses harbor CD8+ T-cell epitopes, capable of being cross-recognized between different coronaviruses.

18 Oct 2021

Study reveals a link between genital warts and the human leukocyte antigen system

New research presented today at the EADV 30th Congress reveals a link between genital warts and the human leukocyte antigen system - the part of the immune system which helps regulate immune responses.

1 Oct 2021

The impact of multiple sclerosis therapy on COVID-19 vaccine efficacy

In a paper, the vaccine-induced cellular and immune response of MS patients receiving a range of therapies are assessed.

23 Sep 2021

Severe COVID-19 is associated with expansion of immature myeloid cells and inflammation

A team of scientists in Ireland recently identified certain immune markers that can predict the progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to severe coronavirus disease 2019 (COVID-19). Early detection of these predictive markers can facilitate therapeutic decision-making prior to peak severity.

7 Sep 2021

'Humanized' mouse model beats current approaches for finding the best organ donor

A "humanized" mouse model equipped with the immune system of a patient who needs an organ transplant beats current measures for identifying the best potential living donor, scientists report.

27 Aug 2021

A spike-derived epitope YLQ induces robust polyfunctional cytotoxic T cell responses in COVID-19 recovered individuals

The findings reveal that the dominant spike-derived epitope induces polyfunctional CD8+ T cell response in coronavirus disease 2019 (COVID-19) recovered individuals. The study is currently available on the bioRxiv* preprint server.

18 Aug 2021

Public and private SARS-CoV-2 T cell receptors may be crucial for pan-coronavirus vaccines

Researchers have just established a structural basis for two spike glycoprotein epitopes of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are restricted to human leukocyte antigen (HLA) A2 molecules. More specifically, they are involved in the presentation of antigenic peptides to specific T lymphocytes and recognized by public and private T cell receptors. The research is currently available on the bioRxiv* preprint server.

2 Aug 2021

CD8+ T cells show gene-dependent variation in cross-reactivity to human coronaviruses

A new study discusses how both different responses to the infection itself and to COVID-19 vaccines are likely the result of genetic differences.

25 Jul 2021

Widespread SARS-CoV-2 mutation escapes vaccine- and infection-induced CD8 T-cell responses

Researchers in the UK have warned that a widespread mutation that has arisen in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to escape recognition by CD8 T-cell responses in both convalescent patients and recipients of the current coronavirus disease 2019 (COVID-19) vaccines.

29 Jun 2021

CD39+ monocyte count higher in pregnant than non-pregnant COVID-19 patients

A new study published on the bioRxiv* server describes the changes in the representation of a subset of activated monocytes in this group of patients.

23 Jun 2021

Metformin potently inhibits SARS-CoV-2-induced cytokine release in monocytes

An interesting new bioRxiv* preprint reports the suppression of monocyte glycolysis and cytokine production when exposed to the virus, following pretreatment with the commonly used drug, metformin.

6 Jun 2021

Gene offers some level of protection from severe Covid

The first evidence of a genetic link explaining why some people who catch Covid-19 don't become sick has been discovered.

5 Jun 2021

Human T cells can target more than 1,400 sites on SARS-CoV-2 virus

In a new paper, scientists from La Jolla Institute for Immunology (LJI) bring together research findings from COVID-19 researchers around the world.

25 May 2021

Researchers investigate immune molecule that helps protect transplanted kidneys

Looking to improve organ transplant success, researchers are working to learn more about how an immune molecule, which also protects a fetus, helps protect some transplanted kidneys, and to develop a synthetic version of that molecule that could help more patients.

18 May 2021