Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
Protein aggregation in neurons linked to gene regulation in Huntington's disease

Protein aggregation in neurons linked to gene regulation in Huntington's disease

New CRISPR technology may help eliminate mutated gene sequence

New CRISPR technology may help eliminate mutated gene sequence

OHSU researchers discover disease in monkeys that mimics childhood neurodegenerative disorder

OHSU researchers discover disease in monkeys that mimics childhood neurodegenerative disorder

Scientists use new drug discovery system to target Huntington’s Disease

Scientists use new drug discovery system to target Huntington’s Disease

Scientists use new drug discovery system to target Huntington’s Disease

Scientists use new drug discovery system to target Huntington’s Disease

New drug discovery system allows scientists to target ‘undruggable’ enzymes

New drug discovery system allows scientists to target ‘undruggable’ enzymes

Scientists take important step to understand mechanisms that cause Huntington's disease

Scientists take important step to understand mechanisms that cause Huntington's disease

Researchers investigate recessive genetic disorder that leads to childhood blindness

Researchers investigate recessive genetic disorder that leads to childhood blindness

New theory on Huntington's disease shows promise to open new avenues of drug development

New theory on Huntington's disease shows promise to open new avenues of drug development

Single-cell RNA sequencing reveals how complex brain circuit works

Single-cell RNA sequencing reveals how complex brain circuit works

CRISPR technique reduces repetitive behavior in fragile X syndrome mouse models

CRISPR technique reduces repetitive behavior in fragile X syndrome mouse models

Researchers use gene editing to reduce autism symptoms in mice

Researchers use gene editing to reduce autism symptoms in mice

Researchers outline a connection between subplate neurons and brain disorders

Researchers outline a connection between subplate neurons and brain disorders

Study unravels new piece of information in the Huntington’s disease puzzle

Study unravels new piece of information in the Huntington’s disease puzzle

Study unravels how nuclear pore complexes transport mRNAs out of the nucleus

Study unravels how nuclear pore complexes transport mRNAs out of the nucleus

Scientists find overlap between causes of RA and Huntington’s disease

Scientists find overlap between causes of RA and Huntington’s disease

CRISPR-based treatment can restore retinal function in mice with eye disease

CRISPR-based treatment can restore retinal function in mice with eye disease

Salk researchers clarify relationship of two neuron types to psychiatric and movement disorders

Salk researchers clarify relationship of two neuron types to psychiatric and movement disorders

Key signaling protein in Huntington's disease found to have deleterious effects on heart function, shows study

Key signaling protein in Huntington's disease found to have deleterious effects on heart function, shows study

Higher consumption of fish linked to better neurological health

Higher consumption of fish linked to better neurological health