Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
Q-Suite Motor Assessment Tool helps detect subtle motor abnormalities in children

Q-Suite Motor Assessment Tool helps detect subtle motor abnormalities in children

Link found between genetic variations and size of the brainstem, other subcortical structures

Link found between genetic variations and size of the brainstem, other subcortical structures

Pluripotent stem cells help advance understanding of how Huntington's disease develops

Pluripotent stem cells help advance understanding of how Huntington's disease develops

Patterns unique to the striatum observed in people with Huntington's disease

Patterns unique to the striatum observed in people with Huntington's disease

UCLA research identifies potential strategy that may halt Huntington's disease

UCLA research identifies potential strategy that may halt Huntington's disease

Apathy can be used as biomarker of Huntington's disease progression

Apathy can be used as biomarker of Huntington's disease progression

Salk researchers develop new gene-editing tool to target broad range of mutations, cell types

Salk researchers develop new gene-editing tool to target broad range of mutations, cell types

Prion disease in mice treated successfully with antisense oligonucleotides

Prion disease in mice treated successfully with antisense oligonucleotides

Nanoparticles used to deliver CRISPR gene editing tools into the cell

Nanoparticles used to deliver CRISPR gene editing tools into the cell

Researchers develop first blood-brain barrier chip using stem cells

Researchers develop first blood-brain barrier chip using stem cells

Study searches for the origins of depressive symptoms in Huntington's disease

Study searches for the origins of depressive symptoms in Huntington's disease

Study sheds light on design of pharmacological strategies to treat depression in Huntington's disease

Study sheds light on design of pharmacological strategies to treat depression in Huntington's disease

Newly discovered mechanism sheds light on how Parkinson’s disease can spread in the brain

Newly discovered mechanism sheds light on how Parkinson’s disease can spread in the brain

Study discovers origin of neurofibromas that develop throughout the skin of NF1 patients

Study discovers origin of neurofibromas that develop throughout the skin of NF1 patients

Study explores why people at risk for Huntington's disease choose not to undergo genetic testing

Study explores why people at risk for Huntington's disease choose not to undergo genetic testing

Scientists discover how mutations in DNA can cause neurodegenerative disease

Scientists discover how mutations in DNA can cause neurodegenerative disease

Nanotubes enable movement of toxic protein linked to Huntington's disease

Nanotubes enable movement of toxic protein linked to Huntington's disease

Drug that treats high blood pressure shows promise against neurodegenerative diseases

Drug that treats high blood pressure shows promise against neurodegenerative diseases

A new role for sensory signals in the brain discovered

A new role for sensory signals in the brain discovered

Mutation in Huntington’s disease may alter interactions of Huntingtin protein with Rac1

Mutation in Huntington’s disease may alter interactions of Huntingtin protein with Rac1