Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
Simple blood test reliably detects signs of Alzheimer’s damage before symptoms

Simple blood test reliably detects signs of Alzheimer’s damage before symptoms

New method to speed up genetic diagnosis of Huntington’s disease

New method to speed up genetic diagnosis of Huntington’s disease

Neuronal cell death in Alzheimer's disease may actually not be a bad thing, shows study

Neuronal cell death in Alzheimer's disease may actually not be a bad thing, shows study

NIPER researcher presents a review on autophagy in neuronal cells

NIPER researcher presents a review on autophagy in neuronal cells

Glial cell maturation is severely impaired in patients with Huntington's disease

Glial cell maturation is severely impaired in patients with Huntington's disease

Study finds epigenetic differences in the brains of individuals with schizophrenia

Study finds epigenetic differences in the brains of individuals with schizophrenia

New research lays out potential path for treatment of Huntington’s disease

New research lays out potential path for treatment of Huntington’s disease

Intellectually active lifestyle confers protection against neurodegeneration in Huntington's patients

Intellectually active lifestyle confers protection against neurodegeneration in Huntington's patients

Antibiotic-resistant bacteria could soon be targeted with Alzheimer's drug

Antibiotic-resistant bacteria could soon be targeted with Alzheimer's drug

Mount Sinai researcher awarded $2.5 million to advance understanding of neurodegenerative diseases

Mount Sinai researcher awarded $2.5 million to advance understanding of neurodegenerative diseases

CZI announces over $51 million funding to fight neurodegenerative diseases

CZI announces over $51 million funding to fight neurodegenerative diseases

First bifacial molecule can invade double-stranded DNA or RNA

First bifacial molecule can invade double-stranded DNA or RNA

C-Path, CHDI and CDISC announce availability of Huntington's Disease Therapeutic Area User Guide

C-Path, CHDI and CDISC announce availability of Huntington's Disease Therapeutic Area User Guide

New form of therapy may stop or reverse progressive vision loss

New form of therapy may stop or reverse progressive vision loss

Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

Genentech announces clinical data from studies investigating risdiplam in spinal muscular atrophy

Genentech announces clinical data from studies investigating risdiplam in spinal muscular atrophy

Blood-brain barrier can be important biomarker for early diagnosis of Alzheimer's disease

Blood-brain barrier can be important biomarker for early diagnosis of Alzheimer's disease

Penn researchers find common thread linking almost all TNR expansion diseases

Penn researchers find common thread linking almost all TNR expansion diseases

Research finds physical connection between the brain's fluid reservoirs and meningeal lymphatics

Research finds physical connection between the brain's fluid reservoirs and meningeal lymphatics

Huntington's disease may take effect much earlier in life than previously believed, study suggests

Huntington's disease may take effect much earlier in life than previously believed, study suggests