Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
Scientists find overlap between causes of RA and Huntington’s disease

Scientists find overlap between causes of RA and Huntington’s disease

CRISPR-based treatment can restore retinal function in mice with eye disease

CRISPR-based treatment can restore retinal function in mice with eye disease

Salk researchers clarify relationship of two neuron types to psychiatric and movement disorders

Salk researchers clarify relationship of two neuron types to psychiatric and movement disorders

Key signaling protein in Huntington's disease found to have deleterious effects on heart function, shows study

Key signaling protein in Huntington's disease found to have deleterious effects on heart function, shows study

Higher consumption of fish linked to better neurological health

Higher consumption of fish linked to better neurological health

Scientists use CRISPR tool to make multiple edits to DNA samples 'in vitro'

Scientists use CRISPR tool to make multiple edits to DNA samples 'in vitro'

Large ALS-causing protein aggregates protect rather than harm neurons

Large ALS-causing protein aggregates protect rather than harm neurons

Scientists find link between over-accumulation of mitochondrial iron and Huntington's disease

Scientists find link between over-accumulation of mitochondrial iron and Huntington's disease

Houston Methodist-led research focuses on rare, inherited neurodegenerative disorder

Houston Methodist-led research focuses on rare, inherited neurodegenerative disorder

Novel method enables researchers to see interaction of star-shaped brain cells in real time

Novel method enables researchers to see interaction of star-shaped brain cells in real time

Researcher finds that shape of misfolded proteins may contribute to Alzheimer’s, Parkinson’s and Huntington’s disease

Researcher finds that shape of misfolded proteins may contribute to Alzheimer’s, Parkinson’s and Huntington’s disease

Adult-onset degenerative disease mechanism begins much earlier than previously thought

Adult-onset degenerative disease mechanism begins much earlier than previously thought

C-Path and CHDI announce launch of Huntington's Disease Regulatory Science Consortium

C-Path and CHDI announce launch of Huntington's Disease Regulatory Science Consortium

Golgi stress signaling pathway found in cells with Huntington’s disease

Golgi stress signaling pathway found in cells with Huntington’s disease

Scientists decode molecular structure of healthy huntingtin protein

Scientists decode molecular structure of healthy huntingtin protein

Patients with Huntington's have lesser cancer than general population

Patients with Huntington's have lesser cancer than general population

UNC gene therapy scientists uncover viral barcode to penetrate blood-brain barrier

UNC gene therapy scientists uncover viral barcode to penetrate blood-brain barrier

Rockefeller scientists develop system to model Huntington’s in human embryonic stem cells

Rockefeller scientists develop system to model Huntington’s in human embryonic stem cells

Researchers uncover key protein that rescues progression of adult spinocerebellar ataxia

Researchers uncover key protein that rescues progression of adult spinocerebellar ataxia

Study finds overall pattern of commonality between Huntington's and Parkinson's

Study finds overall pattern of commonality between Huntington's and Parkinson's