Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

Genentech announces clinical data from studies investigating risdiplam in spinal muscular atrophy

Genentech announces clinical data from studies investigating risdiplam in spinal muscular atrophy

Blood-brain barrier can be important biomarker for early diagnosis of Alzheimer's disease

Blood-brain barrier can be important biomarker for early diagnosis of Alzheimer's disease

Penn researchers find common thread linking almost all TNR expansion diseases

Penn researchers find common thread linking almost all TNR expansion diseases

Research finds physical connection between the brain's fluid reservoirs and meningeal lymphatics

Research finds physical connection between the brain's fluid reservoirs and meningeal lymphatics

Huntington's disease may take effect much earlier in life than previously believed, study suggests

Huntington's disease may take effect much earlier in life than previously believed, study suggests

Proteins that protect neurons from destruction can be delivered through nose

Proteins that protect neurons from destruction can be delivered through nose

Protein aggregation in neurons linked to gene regulation in Huntington's disease

Protein aggregation in neurons linked to gene regulation in Huntington's disease

New CRISPR technology may help eliminate mutated gene sequence

New CRISPR technology may help eliminate mutated gene sequence

OHSU researchers discover disease in monkeys that mimics childhood neurodegenerative disorder

OHSU researchers discover disease in monkeys that mimics childhood neurodegenerative disorder

Scientists use new drug discovery system to target Huntington’s Disease

Scientists use new drug discovery system to target Huntington’s Disease

Scientists use new drug discovery system to target Huntington’s Disease

Scientists use new drug discovery system to target Huntington’s Disease

New drug discovery system allows scientists to target ‘undruggable’ enzymes

New drug discovery system allows scientists to target ‘undruggable’ enzymes

Scientists take important step to understand mechanisms that cause Huntington's disease

Scientists take important step to understand mechanisms that cause Huntington's disease

Researchers investigate recessive genetic disorder that leads to childhood blindness

Researchers investigate recessive genetic disorder that leads to childhood blindness

New theory on Huntington's disease shows promise to open new avenues of drug development

New theory on Huntington's disease shows promise to open new avenues of drug development

Single-cell RNA sequencing reveals how complex brain circuit works

Single-cell RNA sequencing reveals how complex brain circuit works

CRISPR technique reduces repetitive behavior in fragile X syndrome mouse models

CRISPR technique reduces repetitive behavior in fragile X syndrome mouse models

Researchers use gene editing to reduce autism symptoms in mice

Researchers use gene editing to reduce autism symptoms in mice

Researchers outline a connection between subplate neurons and brain disorders

Researchers outline a connection between subplate neurons and brain disorders