Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
IMB researchers make breakthrough in understanding origin of aging process

IMB researchers make breakthrough in understanding origin of aging process

Researchers develop model to explore hard-to-study mutations in human genome

Researchers develop model to explore hard-to-study mutations in human genome

Scientists directly convert skin cells from healthy adults into motor neurons

Scientists directly convert skin cells from healthy adults into motor neurons

Potential rare gene mutation could act as predictor for schizophrenia and autism

Potential rare gene mutation could act as predictor for schizophrenia and autism

New version of gene editing technique corrects molecular mistakes in RNA-based diseases

New version of gene editing technique corrects molecular mistakes in RNA-based diseases

Omeros’ OMS721 receives orphan drug designation from FDA for treatment of IgA nephropathy

Omeros’ OMS721 receives orphan drug designation from FDA for treatment of IgA nephropathy

Expert highlights CRISPR’s applications, limitations, and ethical concerns

Expert highlights CRISPR’s applications, limitations, and ethical concerns

Small-molecule drug improves brain performance in mouse model of Rett syndrome

Small-molecule drug improves brain performance in mouse model of Rett syndrome

CUMC researchers capture first snapshot of key brain receptor in action

CUMC researchers capture first snapshot of key brain receptor in action

Scientists uncover new gene therapy treatment routes for motor neurone disease

Scientists uncover new gene therapy treatment routes for motor neurone disease

Experts develop first freely available data network for Huntington's disease research

Experts develop first freely available data network for Huntington's disease research

Researchers examine formation of functional amyloids by bacteria in real time

Researchers examine formation of functional amyloids by bacteria in real time

Pyk2 deficits contribute to memory problems in Huntington’s disease mouse model

Pyk2 deficits contribute to memory problems in Huntington’s disease mouse model

Study: Abnormal proteins in Alzheimer's, Parkinson's, and Huntington's diseases share similar feature

Study: Abnormal proteins in Alzheimer's, Parkinson's, and Huntington's diseases share similar feature

Scientists to develop drugs for treating cognitive deficits in Huntington's disease sufferers

Scientists to develop drugs for treating cognitive deficits in Huntington's disease sufferers

Researchers discover how tau disrupts functioning of nerve cells even before forming tangles

Researchers discover how tau disrupts functioning of nerve cells even before forming tangles

‘Disease in a dish’ model pinpoints how defects in blood-brain barrier can cause psychomotor disorder

‘Disease in a dish’ model pinpoints how defects in blood-brain barrier can cause psychomotor disorder

Neurobiologists uncover reason for defects in the blood-brain barrier of Huntington's disease patients

Neurobiologists uncover reason for defects in the blood-brain barrier of Huntington's disease patients

Scientists use AHDS patients’ cells to recreate disease and mimic blood-brain barrier

Scientists use AHDS patients’ cells to recreate disease and mimic blood-brain barrier

Sangamo Therapeutics and Pfizer team up for development of Hemophilia A gene therapy

Sangamo Therapeutics and Pfizer team up for development of Hemophilia A gene therapy