Huntington’s Disease News and Research

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Apathy can be used as biomarker of Huntington's disease progression

Researchers from the brain cognition and plasticity group of the Bellvitge Biomedical Research Institute and the Neuroscience Institute of the University of Barcelona have led an innovative study that identifies modifications in the connectivity of cerebral white matter associated with the heterogeneous nature of apathy in Huntington's disease, making it possible to use this syndrome as a biomarker of disease progression.

6 Sep 2019

New study reveals 'clutch' proteins responsible for putting T cell activation 'into gear'

In collaborative research, scientists from three continents were able to discover a crucial bit of information about how T cells move proteins inside them to drive the immune response. This could help evolve specific new treatments centered on T cell selectivity.

12 Jul 2019

Quanterix announces agreement to acquire UmanDiagnostics, world’s leading neurofilament light (Nf-l) antibody supplier

Quanterix announce agreement to acquire privately held UmanDiagnostics AB for $22.5 million.

From Quanterix 26 Jun 2019

Study searches for the origins of depressive symptoms in Huntington's disease

About 40% of the affected patients with Huntington's disease -a neurodegenerative pathology- show depression symptoms, even in early stages before the apparition of the typical motor symptoms of the disease.

31 May 2019

Study sheds light on design of pharmacological strategies to treat depression in Huntington's disease

About 40 % of the affected patients with Huntington's disease -a neurodegenerative pathology- show depression symptoms, even in early stages before the apparition of the typical motor symptoms of the disease.

31 May 2019

Study explores why people at risk for Huntington's disease choose not to undergo genetic testing

As many as 90 percent of individuals who have a parent with Huntington's disease (HD) choose not to take a gene test that reveals if they will also develop the fatal disorder -- and a new study details the reasons why.

17 May 2019

Nanotubes enable movement of toxic protein linked to Huntington's disease

A toxic protein linked to Huntington's disease can move from neuron to neuron through a nanotube tunnel whose construction is initiated by a protein called Rhes, say scientists at Scripps Research.

11 May 2019

Mutation in Huntington’s disease may alter interactions of Huntingtin protein with Rac1

Since 1993, when the gene that causes Huntington's disease was identified, there has been intense focus on understanding how this genetic mutation causes the disease's severe progressive neural deterioration.

4 Apr 2019

CIRM announces funding for UCI researchers to develop new treatment for Huntington’s disease

Following a California Institute for Regenerative Medicine Independent Citizens Oversight Committee meeting held last week, University of California, Irvine researchers learned they will receive $6 million in funding to support the continued development of a promising new treatment for Huntington's disease

5 Feb 2019

New guidelines developed for effective management of neuropsychiatric symptoms of Huntington’s disease

Although Huntington's disease (HD) is traditionally thought of as a neurological disorder, behavioral symptoms are a common feature and frequently cause distress and difficulty to patients, family members, and other caregivers.

30 Jan 2019

New method to speed up genetic diagnosis of Huntington’s disease

Elongated segments of DNA cause Huntington's disease and certain other disorders of the brain. Researchers funded by the SNSF have developed a method to determine the length of the mutated genes quickly and easily.

10 Jan 2019

The Opal: Pushing the Boundaries of Parkinson’s Disease Research

An interview with Dr. Kristen Sowalsky, discussing a wearable gait sensor and its impact on Parkinson’s disease research.

From APDM Wearable Technologies 8 Jan 2019

New mechanism may explain neurons shrinking in Huntington's disease

A hallmark of neurodegenerative diseases like Huntington's is the progressive death of nerve cells in the brain. The cells don't die quickly, though. They first start to disconnect from each other because their neurites -- long finger-like extensions that make connections all through the brain -- become smaller.

25 Dec 2018

Glial cell maturation is severely impaired in patients with Huntington's disease

The neurological disorder Huntington's disease causes behavioral and motor changes, which among other things are a result of dysfunctional maturation or formation of glial cells, the brain's support cells, researchers from the University of Copenhagen demonstrate in a new study based on mice trials.

24 Dec 2018

New research lays out potential path for treatment of Huntington’s disease

New research gives scientists a clearer picture of what is happening in the brains of people with Huntington's disease and lays out a potential path for treatment.

14 Dec 2018

A Preclinical Solution to Studying Neurological Diseases

At SfN 2018, Antti Nurmi explained a case study of how Charles River have used neuroimaging to study Batten's Disease.

From Charles River Laboratories Neuroscience 26 Nov 2018

C-Path, CHDI and CDISC announce availability of Huntington's Disease Therapeutic Area User Guide

The Huntington's Disease Regulatory Science Consortium, launched in March 2018 by the Critical Path Institute and CHDI Foundation, today, along with the Clinical Data Interchange Standards Consortium, announce the open availability of a newly developed Huntington's Disease Therapeutic Area User Guide

2 Nov 2018

Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

A group of Massachusetts General Hospital investigators is proposing that targeting immune checkpoints - molecules that regulate the activity of the immune system - in immune cells called microglia could reduce the inflammatory aspects of important neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.

17 Oct 2018

Alzheimer’s disease researchers makes significant breakthroughs

Researchers in Sweden and United Kingdom have made a breakthrough in Alzheimer’s disease research. They could soon be on the path to develop new drugs that could fight the disease more effectively.

26 Sep 2018

Discovering Prion-like Proteins in Eukaryotic Viruses

Dr. George Tetz discusses the discovery of prion-like domains in eukaryotic viruses, and the implications of this study on gene therapies and common neurological diseases such as Alzheimer's Disease.

6 Sep 2018