Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
Novel microfluidic device used to manipulate major whey protein

Novel microfluidic device used to manipulate major whey protein

Autophagy disruption may be at the root of early cognitive changes in Huntington’s disease

Autophagy disruption may be at the root of early cognitive changes in Huntington’s disease

Dying patients with rare diseases struggle to get experimental therapies

Dying patients with rare diseases struggle to get experimental therapies

Mass spectrometry: An important tool to unravel mechanisms underlying Huntington's disease

Mass spectrometry: An important tool to unravel mechanisms underlying Huntington's disease

Study: Gene editing therapy for early-stage Huntington’s disease may have long-lasting benefits

Study: Gene editing therapy for early-stage Huntington’s disease may have long-lasting benefits

Turning down glial genes can help mitigate Huntington's disease pathogenesis

Turning down glial genes can help mitigate Huntington's disease pathogenesis

Special type of stem cell can reduce the amount of HIV virus

Special type of stem cell can reduce the amount of HIV virus

Biomarker of chronic cellular stress is associated with Huntington's disease, shows study

Biomarker of chronic cellular stress is associated with Huntington's disease, shows study

Researchers identify brain regions involved in seeking information about negative events

Researchers identify brain regions involved in seeking information about negative events

Researchers identify new approach to clear toxic Huntingtin protein

Researchers identify new approach to clear toxic Huntingtin protein

Reversible pharmacological treatment can improvise stuttering in humans

Reversible pharmacological treatment can improvise stuttering in humans

New method shows that tau forms small aggregates as part of the body's normal physiology

New method shows that tau forms small aggregates as part of the body's normal physiology

BrainMap analysis strongly affirms 'network degeneration hypothesis' theory

BrainMap analysis strongly affirms 'network degeneration hypothesis' theory

“Expansion Hunter” method can detect DNA errors that lead to repeat expansion diseases

“Expansion Hunter” method can detect DNA errors that lead to repeat expansion diseases

Targeting brain protein may lead to new therapeutic approaches for neurodegenerative disorders

Targeting brain protein may lead to new therapeutic approaches for neurodegenerative disorders

New consortium aims to accelerate development of stem cell-based therapies for Huntington’s disease

New consortium aims to accelerate development of stem cell-based therapies for Huntington’s disease

Major CIHR grant to help find and tackle the root cause of neurodegenerative disease

Major CIHR grant to help find and tackle the root cause of neurodegenerative disease

Optimized nano-micelles can induce efficient genome editing in the mouse brain

Optimized nano-micelles can induce efficient genome editing in the mouse brain

Optimized nano-micelles can induce efficient genome editing in the mouse brain

Optimized nano-micelles can induce efficient genome editing in the mouse brain

Study shows how mutant huntingtin protein triggers brain cell death

Study shows how mutant huntingtin protein triggers brain cell death