Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
Researchers combine two emerging imaging technologies to better view biomolecules

Researchers combine two emerging imaging technologies to better view biomolecules

Repeated DNA sequences in the genome may contribute to schizophrenia risk

Repeated DNA sequences in the genome may contribute to schizophrenia risk

bit.bio launches Huntington’s disease human cell model

bit.bio launches Huntington’s disease human cell model

New drug shows promise in treating a movement disorder associated with Huntington's disease

New drug shows promise in treating a movement disorder associated with Huntington's disease

Investigational new drug may be safe for patients with mild cognitive impairment, dementia

Investigational new drug may be safe for patients with mild cognitive impairment, dementia

Chaperone-mediated autophagy needed to protect against atherosclerosis

Chaperone-mediated autophagy needed to protect against atherosclerosis

Alzheimer’s disease protein helps skin cancer cells thrive when they metastasize to the brain

Alzheimer’s disease protein helps skin cancer cells thrive when they metastasize to the brain

Single protein elicits multilineage reprogramming of astrocytes in adult mouse brains

Single protein elicits multilineage reprogramming of astrocytes in adult mouse brains

New DNA test can quickly and accurately identify a range of hard-to-diagnose genetic diseases

New DNA test can quickly and accurately identify a range of hard-to-diagnose genetic diseases

Researchers create a comprehensive atlas of cerebrovascular cell types

Researchers create a comprehensive atlas of cerebrovascular cell types

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

Gene therapy can provide long-lasting therapeutic benefit in Huntington's disease

Gene therapy can provide long-lasting therapeutic benefit in Huntington's disease

Common cystic fibrosis drugs work by directly aiding the protein folding process, study shows

Common cystic fibrosis drugs work by directly aiding the protein folding process, study shows

JPND announces call for multinational research on understanding the mechanisms of non-pharmacological interventions

JPND announces call for multinational research on understanding the mechanisms of non-pharmacological interventions

Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

Advanced technique reveals the ultrastructure of huntingtin inclusion bodies

Advanced technique reveals the ultrastructure of huntingtin inclusion bodies

New technology shows great promise for early diagnosis of Alzheimer’s disease

New technology shows great promise for early diagnosis of Alzheimer’s disease

Toxic fatty acids trigger cell death in damaged neurons

Toxic fatty acids trigger cell death in damaged neurons

Buck Institute receives $14 million NIH grant to focus on one of the major drivers of aging

Buck Institute receives $14 million NIH grant to focus on one of the major drivers of aging

Study focuses on psychiatric, cognitive symptoms emerging at early stages of Huntington's disease

Study focuses on psychiatric, cognitive symptoms emerging at early stages of Huntington's disease