Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
Huntington’s disease mutant gene affects brain and body growth in childhood

Huntington’s disease mutant gene affects brain and body growth in childhood

Neuroscientists track gene expression to gain insights into drug addiction, Parkinson's disease

Neuroscientists track gene expression to gain insights into drug addiction, Parkinson's disease

Study reveals innovative gene therapy approach to regenerate functional new neurons

Study reveals innovative gene therapy approach to regenerate functional new neurons

Additional data demonstrates positive results of pridopidine drug on Total Functional Capacity

Additional data demonstrates positive results of pridopidine drug on Total Functional Capacity

Study finds surprising link between ALS, FTD and Huntington's disease-associated mutation

Study finds surprising link between ALS, FTD and Huntington's disease-associated mutation

New method could help determine the most appropriate treatment for HIV patients

New method could help determine the most appropriate treatment for HIV patients

Active bilingualism protects against cognitive decline

Active bilingualism protects against cognitive decline

Study: Optogenetic stimulation of circuit improves symptomatology of Huntington's disease

Study: Optogenetic stimulation of circuit improves symptomatology of Huntington's disease

New strategy shows promises for treating RNA-repeat expansion disorders

New strategy shows promises for treating RNA-repeat expansion disorders

Researchers generate a transcriptomic map of the COVID brain

Researchers generate a transcriptomic map of the COVID brain

Scientists examine a novel approach to analyzing dendritic spine shapes

Scientists examine a novel approach to analyzing dendritic spine shapes

NIH awards $3.8 million to predict dementia in patients with Parkinson's disease

NIH awards $3.8 million to predict dementia in patients with Parkinson's disease

Actively speaking two languages delays the onset of mild cognitive impairment

Actively speaking two languages delays the onset of mild cognitive impairment

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

CZI announces $4.5 million to advance novel approaches in neurodegeneration field

CZI announces $4.5 million to advance novel approaches in neurodegeneration field

Study finds evidence of gut dysbiosis in people with Huntington's disease

Study finds evidence of gut dysbiosis in people with Huntington's disease

Discovery of enzyme could provide new route for treating Huntington's disease

Discovery of enzyme could provide new route for treating Huntington's disease

Artificial intelligence can increase effectiveness of drug repurposing for psychiatric disorders

Artificial intelligence can increase effectiveness of drug repurposing for psychiatric disorders

Erectile dysfunction drugs lower the accumulation of toxic proteins in zebrafish models

Erectile dysfunction drugs lower the accumulation of toxic proteins in zebrafish models

Study reveals intricate details about the biology of huntingtin protein

Study reveals intricate details about the biology of huntingtin protein