Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
Novel brain pathology could improve diagnosis, treatment of neurodegenerative diseases

Novel brain pathology could improve diagnosis, treatment of neurodegenerative diseases

SAFB1 may be a diagnostic marker for neurodegenerative diseases, shows study

SAFB1 may be a diagnostic marker for neurodegenerative diseases, shows study

Researchers develop potential new therapy for common form of muscular dystrophy

Researchers develop potential new therapy for common form of muscular dystrophy

Researchers develop gold nanoparticles to reduce neuronal cell death

Researchers develop gold nanoparticles to reduce neuronal cell death

Scientists use CRISPR tool to make rapid, precise cuts in genomic material

Scientists use CRISPR tool to make rapid, precise cuts in genomic material

Researchers identify two brain phenomena that may explain the side-effects of ketamine

Researchers identify two brain phenomena that may explain the side-effects of ketamine

Research shows potential new therapeutic strategy for slowing down Huntington's disease

Research shows potential new therapeutic strategy for slowing down Huntington's disease

AFFiRiS announces preclinical results of monoclonal antibody mAB C6-17 in Huntington's

AFFiRiS announces preclinical results of monoclonal antibody mAB C6-17 in Huntington's

Scientists uncover why developing nerve cells take a wrong turn

Scientists uncover why developing nerve cells take a wrong turn

New technology developed to map cholesterol metabolism in the brain

New technology developed to map cholesterol metabolism in the brain

New study reveals complex role of immune-system molecule in Huntington's disease

New study reveals complex role of immune-system molecule in Huntington's disease

Scientists gain new insight into the pathological mechanisms behind two neurodegenerative diseases

Scientists gain new insight into the pathological mechanisms behind two neurodegenerative diseases

Nanodevices could prevent plaque formation in the brain

Nanodevices could prevent plaque formation in the brain

Adult brain cells revert back to embryonic state after injury, study finds

Adult brain cells revert back to embryonic state after injury, study finds

Researchers uncover novel role for autophagy in the brain

Researchers uncover novel role for autophagy in the brain

Gene therapy regenerates functional new neurons in mouse models of HD

Gene therapy regenerates functional new neurons in mouse models of HD

Scientists reveal ability to reverse Huntington's disease-causing DNA repeat mutations in the lab

Scientists reveal ability to reverse Huntington's disease-causing DNA repeat mutations in the lab

Researchers discover glial cells that control stress response, extend lifespan in worms

Researchers discover glial cells that control stress response, extend lifespan in worms

Language may be a promising biomarker for progression of Hungtinton's disease

Language may be a promising biomarker for progression of Hungtinton's disease

Inflammation detected in the brains of veterans with Gulf War Illness

Inflammation detected in the brains of veterans with Gulf War Illness