Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
“Expansion Hunter” method can detect DNA errors that lead to repeat expansion diseases

“Expansion Hunter” method can detect DNA errors that lead to repeat expansion diseases

Targeting brain protein may lead to new therapeutic approaches for neurodegenerative disorders

Targeting brain protein may lead to new therapeutic approaches for neurodegenerative disorders

New consortium aims to accelerate development of stem cell-based therapies for Huntington’s disease

New consortium aims to accelerate development of stem cell-based therapies for Huntington’s disease

Major CIHR grant to help find and tackle the root cause of neurodegenerative disease

Major CIHR grant to help find and tackle the root cause of neurodegenerative disease

Optimized nano-micelles can induce efficient genome editing in the mouse brain

Optimized nano-micelles can induce efficient genome editing in the mouse brain

Optimized nano-micelles can induce efficient genome editing in the mouse brain

Optimized nano-micelles can induce efficient genome editing in the mouse brain

Study shows how mutant huntingtin protein triggers brain cell death

Study shows how mutant huntingtin protein triggers brain cell death

Study demonstrates intricate relationship between Prpf19 and Exoc7 in inherited ataxias

Study demonstrates intricate relationship between Prpf19 and Exoc7 in inherited ataxias

Study identifies potential therapeutic target for treatment of Huntington's disease

Study identifies potential therapeutic target for treatment of Huntington's disease

Research provides insight into protein structures that could treat Huntington’s disease

Research provides insight into protein structures that could treat Huntington’s disease

Study addresses multiple challenges of the pathogenesis of Huntington's disease

Study addresses multiple challenges of the pathogenesis of Huntington's disease

New guidance to provide mental health support for people with neurodegenerative conditions

New guidance to provide mental health support for people with neurodegenerative conditions

Protein alteration contributes to degeneration of neuronal populations in Huntington's disease

Protein alteration contributes to degeneration of neuronal populations in Huntington's disease

Cleveland Clinic receives two grants to study therapeutic potential of anti-cancer drug in Alzheimer's

Cleveland Clinic receives two grants to study therapeutic potential of anti-cancer drug in Alzheimer's

£1.6 million grant awarded to advance development of MND drug candidate

£1.6 million grant awarded to advance development of MND drug candidate

Study reveals specific neuronal circuits underlying environment-based value learning

Study reveals specific neuronal circuits underlying environment-based value learning

Huntington’s disease mutant gene affects brain and body growth in childhood

Huntington’s disease mutant gene affects brain and body growth in childhood

Neuroscientists track gene expression to gain insights into drug addiction, Parkinson's disease

Neuroscientists track gene expression to gain insights into drug addiction, Parkinson's disease

Study reveals innovative gene therapy approach to regenerate functional new neurons

Study reveals innovative gene therapy approach to regenerate functional new neurons

Additional data demonstrates positive results of pridopidine drug on Total Functional Capacity

Additional data demonstrates positive results of pridopidine drug on Total Functional Capacity