Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
Gene therapy regenerates functional new neurons in mouse models of HD

Gene therapy regenerates functional new neurons in mouse models of HD

Scientists reveal ability to reverse Huntington's disease-causing DNA repeat mutations in the lab

Scientists reveal ability to reverse Huntington's disease-causing DNA repeat mutations in the lab

Researchers discover glial cells that control stress response, extend lifespan in worms

Researchers discover glial cells that control stress response, extend lifespan in worms

Language may be a promising biomarker for progression of Hungtinton's disease

Language may be a promising biomarker for progression of Hungtinton's disease

Inflammation detected in the brains of veterans with Gulf War Illness

Inflammation detected in the brains of veterans with Gulf War Illness

New genetic screen for Huntington’s disease

New genetic screen for Huntington’s disease

AI analysis of blood samples can predict progression of neurodegenerative disease

AI analysis of blood samples can predict progression of neurodegenerative disease

Research team identifies new roles for Huntington's Disease protein

Research team identifies new roles for Huntington's Disease protein

A molecular switch for repairing damage in central nervous system disorders discovered

A molecular switch for repairing damage in central nervous system disorders discovered

A new kind of testing for patients with Parkinson's disease

A new kind of testing for patients with Parkinson's disease

New technique could lead to better diagnosis and effective tracking of Huntington’s disease

New technique could lead to better diagnosis and effective tracking of Huntington’s disease

University Of Iowa wins $18 million grant to continue study on Huntington's disease

University Of Iowa wins $18 million grant to continue study on Huntington's disease

Scientists evaluate mouse models used for developing new treatments for Huntington's disease

Scientists evaluate mouse models used for developing new treatments for Huntington's disease

Huntington's disease patients need to better understand the risks and benefits of new therapies

Huntington's disease patients need to better understand the risks and benefits of new therapies

Researchers uncover novel pathogenic mechanism in Huntington’s disease

Researchers uncover novel pathogenic mechanism in Huntington’s disease

Fluorescent carbon dots can effectively detect calcium levels in cells

Fluorescent carbon dots can effectively detect calcium levels in cells

Q-Suite Motor Assessment Tool helps detect subtle motor abnormalities in children

Q-Suite Motor Assessment Tool helps detect subtle motor abnormalities in children

Link found between genetic variations and size of the brainstem, other subcortical structures

Link found between genetic variations and size of the brainstem, other subcortical structures

Pluripotent stem cells help advance understanding of how Huntington's disease develops

Pluripotent stem cells help advance understanding of how Huntington's disease develops

Patterns unique to the striatum observed in people with Huntington's disease

Patterns unique to the striatum observed in people with Huntington's disease