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Recycling tubular endosomes are associated with effective delivery of mRNA-based therapeutics, study finds

A recent study recently demonstrates the endosomal transport of nanoparticle-based formulations for the effective delivery of mRNA-based therapeutics.

14 Dec 2021

Announcing the Winners of The Scientist’s Top 10 Innovations of 2021

Each year The Scientist seeks to highlight the latest and greatest tools, technologies, and techniques to hit the life science landscape.

From Resolve Biosciences 6 Dec 2021

Does SARS-CoV-2 infection contribute to adrenal gland dysfunction?

New research suggests that SARS-CoV-2 infection can directly target and cause cellular damage to the adrenal glands.

23 Nov 2021

Study shows SARS-CoV-2 can infect and replicate in human iPSC-derived neurons

In a study recently published on the bioRxiv preprint server, researchers attempted to further increase the scope of previous studies in examining SARS-CoV-2 infection of human CNS resident cells.

22 Nov 2021

“Catching SARS-CoV-2 in the act” – viral infection of nasal mucosa spares nerve cells

A new study discusses the entry of SARS-CoV-2 into the respiratory and olfactory mucosa of the nasal cavity.

4 Nov 2021

Researchers explore how opioids may have become so widely abused

Researchers may have uncovered new answers on how to create safer opioids. Design a new opioid to bypass the part of brain that feels pleasure, but retain the analgesic properties, which make opioids one of the most effective pain relievers.

15 Oct 2021

Role of CRISPR-Cas12a visual biosensor in detection of SARS-CoV-2

A new study aimed to develop a novel CRISPR-Cas12a powered visual biosensor for the detection of SARS-CoV-2.

13 Oct 2021

Plasmonic sensing of isothermally amplified nucleic acids and single-molecule detection of SARS-CoV-2

A new study finds that plasmonic sensing of LAMP amplicons through DNA hybridization enables highly specific detection of SARS-CoV-2 RNA.

11 Oct 2021

Digital spatial profiling of individual glomeruli from HIV and COVID-19 patients

Now, a new study posted to the bioRxiv* server by scientists from the University of Washington explores the use of NanoString’s GeoMx digital spatial profiling (DSP) to investigate CG caused by HIV and SARS-Cov-2 infections.

14 Sep 2021

Understanding how pathogens evolve novel virulence activities

Understanding how pathogens evolve is a fundamental component of learning how to protect ourselves and our world from pests and diseases.

7 Sep 2021

Antisense oligonucleotides engineered to inhibit SARS-CoV-2

In a paper recently uploaded to the bioRxiv* preprint server, structure-based ASOs are developed against SARS-CoV-2, intended to bond with RNA in its structured in situ form, rather than the more rarely encountered linear section, achieving greater affinity and specificity than linear ASOs, and demonstrating inhibition of virus replication in human cells.

30 Aug 2021

Genosensors enable low-cost and rapid SARS-CoV-2 detection

The challenges posed by the COVID-19 pandemic have stimulated innovation on several fronts. One is the development of low-cost methods of clinical diagnosis.

10 Aug 2021

Clinical trials during a pandemic – lessons from COVID-19

In this interview, Dr. Benedicte Roquebert, Dr. Stephanie Haim-Boukobza and Dr. Souad Mehlal discuss how COVID-19 has resulted in new ways to think about clinical trials during a pandemic.

From Cerba Research 23 Jul 2021

MET amplification identified as a potentially actionable driver for non-small cell lung cancer

A study led by D. Ross Camidge, MD, PhD, director of thoracic oncology at the University of Colorado School of Medicine and CU Cancer Center member, has helped to define MET amplification as a rare but potentially actionable driver for non-small cell lung cancer (NSCLC).

20 Jul 2021

Research sheds light on a new mechanism for inhibitory synapse specificity in the cortex

Researchers at the Max Planck Florida Institute for Neuroscience have discovered that the cell adhesion protein IgSF11 determines the layer-specific synaptic connectivity of a distinct class of cortical interneurons.

15 Jul 2021

Study provides important insights into early stages of SARS-CoV-2 infection

Researchers in the UK have provided important new insights into the early stages of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

30 Jun 2021

SARS-CoV-2 test in 20 minutes with FISH

A collaboration from the University of Oxford and the University of Warwick has led to research into a novel method of viral detection through rapid fluorescence in situ hybridization (FISH) in order to effectively detect the SARS-CoV-2 virus within 20 minutes.

29 Jun 2021

SARS-CoV-2 can be neutralized by UV-A and UV-B

Since the end of the 1800s, Ultra-violet (UV) light has been widely documented for its germicidal properties. The UV-C light produced by low-pressure mercury tubes is widely used for disinfecting wastewater, closed environments, and biological products and is well-established, safe, and economical. UV light can have a germicidal effect on bacteria and viruses.

2 Jun 2021

A novel multiplexed diagnostic approach for COVID-19

Researchers developed a platform for detecting the virus directly from a patient's sample as well as the immune response through antibodies such as IgG and IgM.

31 May 2021

Oxytocin-vasopressin circuit has distinct dynamics throughout embryonic development

The work, carried out by Pilar Madrigal and Sandra Jurado, from the UMH-CSIC Neurosciences Institute in Alicante, a joint center of the Spanish National Research Council and Miguel Hernández University, has been published in Communications Biology, a Nature group´s journal.

22 May 2021