Hypercholesterolemia News and Research

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Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood. Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods that come from animals (particularly egg yolks, meat, poultry, fish, and dairy products). The body needs this substance to build cell membranes, make certain hormones, and produce compounds that aid in fat digestion. Too much cholesterol, however, increases a person's risk of developing heart disease.

People with hypercholesterolemia have a high risk of developing a form of heart disease called coronary artery disease. This condition occurs when excess cholesterol in the bloodstream is deposited in the walls of blood vessels, particularly in the arteries that supply blood to the heart (coronary arteries). The abnormal buildup of cholesterol forms clumps (plaque) that narrow and harden artery walls. As the clumps get bigger, they can clog the arteries and restrict the flow of blood to the heart. The buildup of plaque in coronary arteries causes a form of chest pain called angina and greatly increases a person's risk of having a heart attack.

Inherited forms of hypercholesterolemia can also cause health problems related to the buildup of excess cholesterol in other tissues. If cholesterol accumulates in tendons, it causes characteristic growths called tendon xanthomas. These growths most often affect the Achilles tendons and tendons in the hands and fingers. Yellowish cholesterol deposits under the skin of the eyelids are known as xanthelasmata. Cholesterol can also accumulate at the edges of the clear, front surface of the eye (the cornea), leading to a gray-colored ring called an arcus cornealis.
Nanoparticles carrying CRISPR gene editing tools for genetic modifications

Nanoparticles carrying CRISPR gene editing tools for genetic modifications

Junk genes could one day offer framework for treating people with familial hypercholesterolemia

Junk genes could one day offer framework for treating people with familial hypercholesterolemia

Study: Liver inflammation increases cholesterol levels in people with diabetes

Study: Liver inflammation increases cholesterol levels in people with diabetes

PCSK9 Inhibitors: Highlights barriers to new, breakthrough cholesterol-lowering drugs

PCSK9 Inhibitors: Highlights barriers to new, breakthrough cholesterol-lowering drugs

Researchers solve medical mystery through genetics

Researchers solve medical mystery through genetics

Amgen, UCB present romosozumab Phase 2 results at ENDO 2017

Amgen, UCB present romosozumab Phase 2 results at ENDO 2017

Novel synthetic HDL-C injection shows no benefit on arterial plaques

Novel synthetic HDL-C injection shows no benefit on arterial plaques

UAB researchers developing new peptide that may help combat familial hypercholesterolemia

UAB researchers developing new peptide that may help combat familial hypercholesterolemia

Endogenous peptide inhibits atherosclerosis by reducing cholesterol levels

Endogenous peptide inhibits atherosclerosis by reducing cholesterol levels

Linking human genome sequences to EHR information could influence clinical medicine, says expert

Linking human genome sequences to EHR information could influence clinical medicine, says expert

Research shows how mitochondrial targeting antioxidants could help treat osteoarthritis

Research shows how mitochondrial targeting antioxidants could help treat osteoarthritis

Moderately vigorous physical activity in midlife linked to better cognition at old age

Moderately vigorous physical activity in midlife linked to better cognition at old age

Lipoprotein apheresis may have new role in patients with refractory angina

Lipoprotein apheresis may have new role in patients with refractory angina

PCSK9 inhibitor can reduce need for apheresis treatment in patients with familial hypercholesterolemia

PCSK9 inhibitor can reduce need for apheresis treatment in patients with familial hypercholesterolemia

Increased parental longevity linked to lower risk of cardiovascular conditions in offspring

Increased parental longevity linked to lower risk of cardiovascular conditions in offspring

CHD rates decrease significantly in the U.S.

CHD rates decrease significantly in the U.S.

First generic version of Crestor gets FDA approval

First generic version of Crestor gets FDA approval

Study finds how tumour cells grow through scavenging bad cholesterol

Study finds how tumour cells grow through scavenging bad cholesterol

Study demonstrates rarity of familial hypercholesterolemia mutations in individuals with high cholesterol

Study demonstrates rarity of familial hypercholesterolemia mutations in individuals with high cholesterol

PCSK9-inhibitor drugs: A game-changer for individuals with extremely high cholesterol levels

PCSK9-inhibitor drugs: A game-changer for individuals with extremely high cholesterol levels