Hypoplastic News and Research

RSS

Gout medication may help improve heart function in adult patients

Researchers at the University of Cincinnati College of Medicine have shown that probenecid, a drug long used to treat gout, may be able to improve heart function in adult patients who experience heart failure.

20 Feb 2018

CHLA participates in clinical trial using stem cells to treat rare congenital heart defect

Children's Hospital Los Angeles is announcing participation in the first-ever clinical trial using stem cells from umbilical cord blood to delay or even prevent heart failure in children born with a rare congenital heart defect that leaves them with half a heart.

5 Feb 2018

Pitt scientists discover genes responsible for severe congenital heart disease

The first known identification of two genes responsible for hypoplastic left heart syndrome (HLHS), a severe congenital heart defect, has been reported by researchers at the University of Pittsburgh School of Medicine.

22 May 2017

Clinical study tests adult stem cell therapy for infants with congenital HLHS

In a first-in-children randomized clinical study, medical researchers at the University of Maryland School of Medicine and the Interdisciplinary Stem Cell Institute at the University of Miami Miller School of Medicine have begun testing to see whether adult stem cells derived from bone marrow benefit children with the congenital heart defect hypoplastic left heart syndrome (HLHS).

21 Dec 2016

CHLA cardiologists perform rare fetal cardiac intervention procedure

Last August, when Children's Hospital Los Angeles cardiologists confirmed that the heart of a 27-week-old fetus suffered from a critical cardiac condition that prevented blood returning from the fetus's lungs from circulating back into the body, they told the parents that their child faced certain open-heart surgery after birth. Even worse, babies born with this very rare condition—hypoplastic left heart syndrome (HLHS) with restrictive atrial septum—have a 50 percent neonatal mortality rate.

27 Feb 2016

Arterial shunt in hybrid palliation better for hypoplastic left heart syndrome treatment

Children born with the major congenital heart defect hypoplastic left heart syndrome (HLHS) often must undergo a series of corrective surgeries beginning at birth. While most have the standard three-stage Norwood procedure, a hybrid strategy has been introduced to offset some disadvantages associated with the Norwood surgeries. In a report in The Journal of Thoracic and Cardiovascular Surgery, investigators compare whether outcomes can be improved if an arterial shunt is used as a source of pulmonary blood flow rather than the more conventional venous shunt as part of the hybrid strategy of HLHS surgical reconstruction.

14 Aug 2015

Eight clinical researchers selected as finalists for Outstanding Investigator Award at Cardiology 2015

Pediatric cardiology researchers and clinicians from numerous centers from around the world are gathering at the Cardiology 2015: the 18th Annual Update on Pediatric and Congenital Cardiovascular Disease conference, sponsored by The Children's Hospital of Philadelphia and Phoenix Children's Hospital on Feb. 11 to Feb. 15 in Scottsdale, Ariz.

16 Feb 2015

Experts gather at Cardiology 2015 conference to discuss challenges in treating congenital heart disease

Many aspects of pediatric cardiology are relatively new to the discipline. Only recently have physicians been able to accurately diagnose and characterize the myriad congenital cardiovascular conditions that occur and begin to apply successful strategies for care. This week, an international group of more than 800 medical experts gather at the nation's largest pediatric cardiology conference to discuss challenges in treating congenital heart disease in the fetus, neonates, children and young adults.

12 Feb 2015

Experts to discuss challenges in CHD treatments at pediatric cardiology conference

12 Feb 2015

Innovative treatment option for children with plastic bronchitis

A case study published recently in the journal Pediatrics describes an innovative, minimally invasive procedure that treated plastic bronchitis, a potentially life-threatening disease, in a six-year-old boy with a heart condition. Using new lymphatic imaging tools and catheterization techniques, physician-researchers eliminated bronchial casts, which are an accumulation of lymphatic material that clogged the child's airway.

22 Oct 2014

Costs of care differ significantly across hospitals for children born with heart defects

Costs of care differ significantly across hospitals for children born with heart defects, according to new research led by a University of Michigan researcher. Congenital heart defects are known to be the most common birth defects, impacting nearly 1 in every 100 births.

25 Feb 2014

Study reveals that more than 14% of pregnant women are prescribed opioids for pain

More than 14 percent of pregnant women were prescribed opioids (narcotics) for pain at some time during their pregnancy, according to a study posted to the online version of Anesthesiology.

13 Feb 2014

Multi-center study finds causes for neonatal mortality in infants with HLHS

A first-of-its-kind study led by Texas Children's Hospital and Baylor College of Medicine, published online in the journal, Circulation, found that infants with hypoplastic left heart syndrome born far from a hospital providing neonatal cardiac surgery for HLHS have increased neonatal mortality, with most deaths occurring before surgery.

24 Oct 2013

Vera and Paul Guerin Family Congenital Heart Program to be established in Cedars-Sinai Heart Institute

In an effort to lengthen the life span and improve the quality of life for those born with heart defects, longtime Cedars-Sinai supporters Vera and Paul Guerin have donated $10 million to establish the Vera and Paul Guerin Family Congenital Heart Program in the Cedars-Sinai Heart Institute.

20 Sep 2013

Mayo Clinic announces first US stem cell clinical trial for children with hypoplastic left heart syndrome

Mayo Clinic has announced the first U.S. stem cell clinical trial for pediatric congenital heart disease. The trial aims to determine how stem cells from autologous umbilical cord blood can help children with hypoplastic left heart syndrome, a rare defect in which the left side of the heart is critically underdeveloped.

12 Jun 2013

Cardiac stem cells from newborns show stronger regenerative ability

Researchers at the University of Maryland School of Medicine, who are exploring novel ways to treat serious heart problems in children, have conducted the first direct comparison of the regenerative abilities of neonatal and adult-derived human cardiac stem cells.

11 Sep 2012

New surgical technique may repair common, painful hip condition in elite athletes

A common, painful hip condition in elite athletes may be able to be repaired with an improved surgical technique, according to researchers presenting their work at the American Orthopaedic Society for Sports Medicine's Annual Meeting in Baltimore, Maryland today.

16 Jul 2012

Seattle Children's Hospital performs 100th heart transplant on 5-month-old baby

On Saturday, April 28, a 5-month-old baby received the 100th heart transplant performed at Seattle Children's Hospital, a significant milestone for him as well as the hospital's Heart Center and Heart Transplant Program teams.

7 May 2012

TCFC completes two in-utero fetal cardiac interventions to treat HLHS

The team at Texas Children's Fetal Center, a national leader for treating fetal anomalies, has successfully completed two in-utero fetal cardiac interventions to treat hypoplastic left heart syndrome (HLHS), a congenital heart defect that is one of the most complex heart defects to treat.

5 May 2012

Innate patient factors, overall morbidity affect neurodevelopment in infants with single-ventricle disease

In the largest multicenter clinical trial of children undergoing early-stage surgery for single-ventricle heart defects, differences in intraoperative management did not significantly affect neurodevelopmental outcomes at 14 months of age. Instead, the strongest influences were innate patient characteristics and general medical morbidity during the child's first year of life.

6 Apr 2012