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Clinical study shows that drug improves endothelial function in sickle cell disease patients

Itamar Medical, an international medical technology company developing noninvasive diagnostic technology using the Peripheral Arterial Tone (PAT) Signal, announced today the use of the company's patented Endo-PAT2000 in BioMarin Pharmaceutical Inc.'s phase 2 study of patients with Sickle Cell Disease (SCD). The Endo-PAT2000 was used to measure endothelial function in a study designed to evaluate whether the drug 6R-BH4 can improve endothelial function in SCD patients

5 Dec 2008

Breakthrough in sickle cell disease and thalassemia research

Researchers have identified a gene that directly affects the production of a form of hemoglobin that is instrumental in modifying the severity of the inherited blood disorders sickle cell disease and thalassemia.

5 Dec 2008

Gene therapy used to alleviate sickle cell disease pathology

Using a harmless virus to insert a corrective gene into mouse blood cells, scientists at St. Jude Children's Research Hospital have alleviated sickle cell disease pathology.

3 Dec 2008

Children with sickle cell disease have inadequate healthcare

A new study finds that youth populations with sickle cell disease (SCD) are receiving inadequate healthcare, and thus may fail to benefit from scientific advances.

24 Nov 2008

New approach to bone marrow transplantation found to be a safe and effective cure for sickle cell disease

A unique approach to bone marrow transplantation pioneered in part by a Children's Hospital of Pittsburgh of UPMC physician has proven to be the only safe and effective cure for sickle cell disease, according to a new study.

8 Nov 2008

New sickle cell unrelated transplant trial

Children's National Medical Center immunologist and blood and marrow transplant physician Naynesh Kamani, MD, will serve as the study co-chair for a new national clinical trial of unrelated donor marrow and umbilical cord blood transplants for severe sickle cell disease.

18 Aug 2008

Federal health plan, Medicare do not cover routine HIV screening as recommended by CDC

Medicare and federal health care plans that provide coverage under the Federal Employees Health Benefit Plan do not offer payment for routine HIV screening of people ages 13 to 64 -- a practice that was recommended by CDC in 2006 -- Bloomberg reports.

3 Aug 2008

New understanding of fetal hemoglobin regulation in patients with sickle cell disease

Although sickle cell disease is a single-gene disorder, its symptoms are highly variable. In a study published online July 14 by the Proceedings of the National Academy of Sciences, scientists at Children's Hospital Boston and the Dana Farber Cancer Institute (DFCI), in collaboration with the Broad Institute of MIT and Harvard, report five gene variants that could potentially be helpful in predicting sickle cell disease severity, perhaps even leading to better treatment approaches in the future.

15 Jul 2008

Premature babies feel pain but don't show it

Brain scans of premature babies undergoing a simple medical procedure have revealed though they may appear to be pain free, they are experiencing pain.

24 Jun 2008

Hydroxyurea treatment for sickle cell underused by doctors

Uncertainties about proper use and possible long-term effects of hydroxyurea in the treatment of sickle cell anemia may be wrongly influencing doctors to avoid prescribing it to those in serious need, according to results of a literature review by specialists at Johns Hopkins.

17 Jun 2008

Aggregates of red and white blood cells may contribute to sickle cell disease

It's long been known that patients with sickle cell disease have malformed, "sickle-shaped" red blood cells - which are normally disc-shaped - that can cause sudden painful episodes when they block small blood vessels.

28 Apr 2008

Bosentan drugs offers new approach to limiting organ damage in sickle cell disease

Sickle cell disease (SCD) is so called because of the abnormal sickle shape of the red blood cells in individuals with this blood disorder.

2 Apr 2008

Cause of prolonged penile erection

Priapism (prolonged penile erection in the absence of sexual interest) is common in male individuals with sickle cell disease (SCD), a blood disorder characterized by abnormally shaped red blood cells.

14 Mar 2008

Predictors for sickle-cell-anemia complications

Researchers at UT Southwestern Medical Center have determined that the level, or saturation, of oxygen in blood could be used to identify children with sickle cell anemia who are at an increased risk of stroke.

6 Mar 2008

Researchers investigate predictors for sickle-cell-anemia complications

1 Mar 2008

Hydroxyurea for sickle cell patients

An independent panel convened this week by the NIH concluded that the use of hydroxyurea for sickle cell patients should be increased in adolescents and adults.

28 Feb 2008

Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells

Researchers are identifying innovative therapeutics for sickle cell anemia that focus on specific factors in the disease's progression, such as the important role of hydration of the red blood cells.

7 Feb 2008

Variation in the BCL11A gene linked to moderated symptoms of beta-thalassemia

Beta-thalassemia is a serious, potentially life-threatening disease that affects red blood cells, cells that carry oxygen via hemoglobin throughout the body.

4 Feb 2008

Sickle cell disease pain study

A new prospective study of pain in adults with sickle cell disease finds that daily pain is far more prevalent and severe than previous large studies have indicated.

15 Jan 2008

Authorities in the U.S. say hold back on children's Hib vaccine

Health authorities in U.S. are advising doctors to defer giving booster shots of a childhood vaccine following suspicions that production equipment may not have been properly sterilized.

20 Dec 2007