I Cell Disease News and Research

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Cancer cell line developed that is resistant to new cancer therapy

A cancer cell line that is resistant to one of the newest classes of cancer treatments has been developed by researchers who already are using it to determine what else to give patients when this happens.

12 Dec 2007

Children with sickle cell disease, silent strokes show some relief with blood transfusions

A group of children who have sickle cell disease and who experience silent strokes showed some relief from the silent strokes with blood transfusion therapy, researchers at Washington University School of Medicine in St. Louis have found.

10 Dec 2007

Discovery of new hemoglobin function

A team of researchers from Wake Forest University, the National Institutes of Health and other institutions has discovered a previously undetected chemical process within the oxygen-carrying molecule hemoglobin that could have far-reaching implications for the treatment of cardiovascular diseases.

6 Nov 2007

Anticlotting drug found to be safe in sickle cell patients

An intravenous "blood thinner" widely used in patients with acute coronary syndromes and during coronary artery stent placement appears to be safe in patients with sickle cell disease and may have beneficial anti-inflammatory effects, a small study at the University of North Carolina at Chapel Hill School of Medicine has found.

12 Oct 2007

Hemoglobin-based oxygen carrier shows promise as treatment for sickle cell disease

Studies in mice suggest that a red blood cell substitute based on human hemoglobin could be a promising new treatment for sickle cell disease in humans.

24 Jul 2007

New method to estimate sickle cell disease severity

Researchers from Boston University School of Medicine (BUSM) and Boston University School of Public Health (BUSPH) have developed a method to estimate sickle cell disease severity and predict the risk of death in people with this disease.

12 Jul 2007

Include children in research to make breakthroughs in child medicine

Scientists will only make real breakthroughs in children's medicine if they include children in research programmes as well as adults, according to a leading paediatric expert.

9 Jul 2007

Bone marrow microenvironment can contribute to blood cell disorder

Disorders of blood cells may begin in the biological environment where the cells develop, not just with the cells themselves, according to a study from researchers at the Massachusetts General Hospital (MGH) and the Peter MacCallum Cancer Center (Peter Mac) in Melbourne, Australia.

17 Jun 2007

Steroidal hormones for contraception in women with sickle cell disease

Hormonal contraceptives are unlikely to predispose women to type 2 diabetes and appear to be safe for those with sickle cell anemia.

4 May 2007

BioMarin starts phase 2a study of 6R-BH4 in sickle cell disease

BioMarin Pharmaceutical has announced that the first patient has initiated treatment in the Phase 2a clinical study of 6R-BH4 (sapropterin dihydrochloride) for the treatment of sickle cell disease (SCD).

4 May 2007

Serious illness among children with sickle cell disease reduced with pneumococcal conjugate vaccine

A vaccine introduced in 2000 has reduced by more than 90 percent the rate of a serious bacterial illness among young children with sickle cell disease (SCD), who are particularly susceptible to it, according to a new study that appears in the June 1 issue of Clinical Infectious Diseases and currently is available online.

2 May 2007

GenoMed prevents sickle cell pain for over a year

GenoMed has announced the publication of a case report of a sickle cell patient whose pain has disappeared for over a year thanks to GenoMed's treatment.

12 Mar 2007

Stroke risk for sickle cell children with early complications

Children with sickle cell disease who experienced major complications such as pain and lung disease early in life are at no greater risk for stroke or death during later childhood, new research from UT Southwestern Medical Center shows.

30 Jan 2007

Cure for sickle cell pain

GenoMed announced today that it has submitted a case report of a sickle cell patient whose pain disappeared with GenoMed's treatment approach, only to recur when GenoMed's treatment was stopped.

11 Sep 2006

Prenatal diagnostic tests have low risk of miscarriage

Pregnant women who seek prenatal diagnostic testing to identify genetic or chromosomal abnormalities have a lower risk of miscarriage than previously believed, according to a UCSF study.

31 Aug 2006

Anomalous renal effects of tin protoporphyrin in a murine model of sickle cell disease

Researchers have unexpectedly shown that sickle cell-associated kidney injury may be reduced by inhibiting the enzyme activity of a protein that commonly confers protection in other diseased states.

19 Jul 2006

Healthy habits and appropriate treatments help prevent stroke

Stroke is the third leading cause of death and a major source of disability in the United States. Every year about 700,000 people in the United States suffer a stroke, resulting in nearly 158,000 deaths.

10 May 2006

Europe slow to implement infant pneumococcal vaccine programmes

Up to 90 per cent of cases of invasive pneumococcal diseases (IPD) - which includes serious infections like meningitis - occur in otherwise healthy young children, according to a study published in the April issue of IJCP, the International Journal of Clinical Practice.

13 Apr 2006

Boot camp death from beating

The family of a young boy who died at a Florida boot camp, who alleged that his death was suspicious, have been vindicated by a second autopsy.

15 Mar 2006

Test for LDH enzyme may help determine risk factors in sickle cell disease

Researchers have found that a simple test for an enzyme called LDH may have significant importance for determining major risk factors in adults with sickle cell disease.

9 Mar 2006