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Researcher studies how sickle cell disease affects blood flow and oxygen delivery

Sickle Cell Disease is rare but devastating. Due to a genetic mutation affecting hemoglobin, the component of the red blood cell that carries oxygen, a reduced amount of oxygen is supplied to vital tissues and organs.

7 Feb 2019

New clinical practice guideline on home oxygen therapy for children

The American Thoracic Society has developed a new clinical practice guideline for home oxygen therapy for children. The guideline appears in the Feb. 1 edition of the Society's American Journal of Respiratory and Critical Care Medicine.

4 Feb 2019

African scientists to build research capacity in African countries, develop ongoing scientific partnerships

Ten African scientists have been selected for training at the National Institutes of Health as part of a new fellowship program to build research capacity in African countries and develop ongoing scientific partnerships.

24 Jan 2019

New method modifies blood stem cells to reverse genetic mutation that causes IPEX

UCLA researchers led by Dr. Donald Kohn have created a method for modifying blood stem cells to reverse the genetic mutation that causes a life-threatening autoimmune syndrome called IPEX.

11 Jan 2019

New massive sequencing platform implemented for double factor preimplantation genetic testing

A research team from the Universitat Autònoma de Barcelona, in collaboration with the Blood and Tissue Bank of Catalonia, has managed to implement a massive sequencing platform for Preimplantation Genetic Testing for the first time in history.

5 Dec 2018

Johns Hopkins researchers report challenges in treating severe crisis pain of sickle cell disease

In a study tracking the severe crisis pain of sickle cell disease and its management in 73 adults over a period of a year, Johns Hopkins researchers found that even among those on high doses of daily at-home opioids, a persistent subset was more likely to seek emergency hospital care for crisis pain and was less likely to have the pain controlled by intensive treatment.

27 Nov 2018

FDA approves novel molecular-based assay to help determine blood compatibility

The U.S. Food and Drug Administration today approved ID CORE XT, a molecular-based assay used in blood transfusion medicine to help determine blood compatibility.

11 Oct 2018

Study sheds light on how vaso-occlusive pain crises arise in sickle-cell disease

One of the most common complications of sickle-cell disease occurs when deformed red blood cells clump together, blocking tiny blood vessels and causing severe pain and swelling in the affected body parts.

4 Sep 2018

Study reveals molecular mechanisms underlying expansive arterial remodeling

Expansive arterial remodeling comprises a genetically programmed biological response designed to restore homeostatic levels of arterial wall stress after an increase in vessel flow load occurs.

25 Aug 2018

NIH grant for Mount Sinai to study use of inhaled corticosteroids for treatment of sickle cell disease

The Departments of Emergency Medicine and Hematology at the Icahn School of Medicine at Mount Sinai have been awarded a $4 million grant from the National Institutes of Health toward further study of inhaled corticosteroids to treat sickle cell disease in individuals who do not have asthma.

14 Aug 2018

Using CRISPR-Cas9 genome editing to correct mutation responsible for sickle cell disease

Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells. Prior to adoption as a medical therapeutic, safety concerns relating to off-target effects must be minimized to mitigate risks that may arise from the unintended action of this system at sites similar, but not identical, to the desired gene target site.

From Integrated DNA Technologies 10 Aug 2018

Therapy with L-Glutamine reduces pain in patients with sickle cell disease

UCSF Benioff Children's Hospital Oakland clinical researchers, in conjunction with other sickle cell centers and scientists at Emmaus Life Sciences, Inc., have demonstrated that therapy with L-Glutamine reduced the frequency of pain episodes in both pediatric and adult patients with sickle cell disease.

27 Jul 2018

Researchers identify enzyme as potential new drug target for blood disorders

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease.

20 Jul 2018

CRISPR/Cas9 gene editing can cause greater genetic damage than previously thought

Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. These results create safety implications for gene therapies using CRISPR/Cas9 in the future as the unexpected damage could lead to dangerous changes in some cells.

16 Jul 2018

New guideline recommends first-trimester screening of pregnant women for asymptomatic bacteriuria

First-trimester screening of pregnant women for asymptomatic bacteriuria -- higher than normal bacteria levels without symptoms of a bladder infection -- is recommended by the Canadian Task Force on Preventive Health Care in an updated guideline in CMAJ

9 Jul 2018

Music therapy shows promise for improving lives of people with sickle cell disease

A new study published in the Journal of Music Therapy reveals promising findings for the application of improvisational music therapy in assuaging the multidimensional acute pain of adult patients with sickle cell disease.

14 Jun 2018

Acetaminophen use helps reduce acute kidney injury risk in pediatric heart surgery patients

Children who underwent cardiac surgery were less likely to develop acute kidney injury if they had been treated with acetaminophen in the first 48 hours after their procedures, according to a Vanderbilt study just published in JAMA Pediatrics.

15 May 2018

Study: Stigmatizing language in medical records may play a role in how the patient is treated

A Johns Hopkins study found that physicians who use stigmatizing language in their patients' medical records may affect the care those patients get for years to come.

9 May 2018

Doctors cure sickle cell patients using allogeneic stem cells

Seven adults with sickle cell disease have been cured by doctors at the University of Illinois Hospital, thanks to the development of a new protocol for stem cell transplantation.

25 Apr 2018

Pitt researcher secures nearly $5 million NIH funding for 'Tic-Tac-Toe' RF coil system

The University of Pittsburgh houses a whole-body 7 Tesla magnetic resonance imager (7T MRI), one of the strongest human MRI devices in the world and a powerful imaging tool that allows researchers to gain a far better understanding of brain structure and function.

13 Apr 2018