Immune Response News and Research

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Landmark study characterizes evolution of symptoms, signs of acute HIV infection

Acute HIV infection (AHI) contributes significantly to HIV transmission and may be important for intervention strategies seeking to reduce incidence and achieve a functional cure.

19 May 2016

Crtc switch activated during fasting helps halt spread of intestinal bacteria into bloodstream

A molecular pathway that is activated in the brain during fasting helps halt the spread of intestinal bacteria into the bloodstream, according to a new study by a team of researchers at the Salk Institute.

18 May 2016

Food components can have significant influence on immune system

An international team of researchers under the leadership of the LIMES Institute and the excellence cluster ImmunoSensation of the University of Bonn unraveled a new regulatory mechanism how food components and environmental factors influence the immune system.

18 May 2016

Could worm infection counter IBD? An interview with Dr Loke and Dr Cadwell

The hygiene hypothesis refers to the idea that decreased exposure to certain infectious agents (because of better hygiene) is the reason why we have seen an increase in inflammatory diseases in the developed world.

17 May 2016

Researchers reveal new mechanism that helps breast cancer cells engage MDSCs

Not every breast cancer tumor follows the same path to grow. Some tumors have the assistance of myeloid-derived suppressor cells (MDSCs), a diverse type of immune cell involved in the suppression of the body's response against tumors.

17 May 2016

Potential vaccine that resembles sugar structures may help fight against gut bacterium C. difficile

A vaccine against one of the most dangerous hospital germs may soon be available. Scientists from the Max Planck Institute of Colloids and Interfaces in Potsdam and the Freie Universität Berlin have developed a substance that elicits an immune response against the gut bacterium Clostridium difficile.

13 May 2016

Mouse models of Zika virus infection in pregnancy provide basis to develop vaccines, treatments

Two mouse models of Zika virus infection in pregnancy have been developed by a team of researchers at Washington University School of Medicine in St. Louis. In them, the virus migrated from the pregnant mouse's bloodstream into the placenta, where it multiplied, then spread into the fetal circulation and infected the brains of the developing pups.

12 May 2016

Simultaneous DNA, RNA and protein analysis to enhance cancer immunology studies: an interview with Dr Joseph Beechem

Cancer immunology is all about how your immune cells are going to fight and kill your tumor cells. If you look at the pure genetic code of a T-cell that's going to kill your tumor compared to the same cell that has been “put-to-sleep” (by the tumor), the pure genetic DNA content of those two cells are identical.

From NanoString Technologies 11 May 2016

lncRNA in placenta may help protect unborn baby from invading pathogens

The human placenta is an organ unlike any other. During the course of nine months it is formed by the embryo, sustains life and then is shed.

10 May 2016

Caltech researchers discover new potential cause for Crohn's disease

The community of beneficial bacteria that live in our intestines, known as the gut microbiome, are important for the development and function of the immune system. There has been growing evidence that certain probiotics--therapies that introduce beneficial bacteria into the gut--may help alleviate some of the symptoms of intestinal disorders such as Crohn's disease.

10 May 2016

Research shows spleen MZ B cells produce signaling proteins involved in inflammatory responses

The inability to adequately respond to infection can cause a whole-body state of inflammation known as sepsis. This can eventually lead to systemic inflammatory response syndrome (SIRS), and even death.

9 May 2016

Study hints at new therapeutic approach to mitigate effects of prenatal Zika virus infection

The U.S. Centers for Disease Control and Prevention recently concluded that Zika virus infection in pregnant women can stunt neonatal brain development, leading to babies born with abnormally small heads, a condition known as microcephaly. Now, for the first time, researchers at University of California San Diego School of Medicine have determined one way Zika infection can damage developing brain cells.

9 May 2016

New antibody-based therapy may provide better strategy for long-term control of HIV

The development of antiretroviral therapy, a combination of drugs that slows the replication of HIV in the body, has transformed the treatment of this infection. What was once a certain death sentence is now a chronic condition that people can live with for decades.

9 May 2016

T cell gives precise mechanical tugs to detect friends and foes

T cells, the security guards of the immune system, use a kind of mechanical "handshake" to test whether a cell they encounter is a friend or foe, a new study finds.

6 May 2016

Study sheds light on development of ILCs that play vital role in body's immune defense

Through the use of powerful genomic techniques, researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases have found that the development of immune cells, called innate lymphoid cells (ILCs), gradually prepares these cells for rapid response to infection. This work, which appeared online today in Cell, sheds light on the development and function of a cell type that is increasingly recognized as having an important role in the body's immune defense. NIAMS is part of the National Institutes of Health.

6 May 2016

Duke scientists develop human-derived antibody that preferentially attacks cancer cells

A research team from Duke Health has developed an antibody from the body's own immune system that preferentially attacks cancer cells.

6 May 2016

Experimental drug ozanimod moderately effective in treatment of ulcerative colitis

Researchers at University of California San Diego School of Medicine have shown that ozanimod (RPC1063), a novel drug molecule, is moderately effective in the treatment of ulcerative colitis. Results of the Phase II clinical trial will appear in the May 5 issue of the New England Journal of Medicine.

5 May 2016

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

University of Alabama at Birmingham researchers report the first documentation that suppressing a key cell-signaling pathway in a rat model of Parkinson's disease reduces pathogenesis. Oral administration of AZD1480 — one of the JAK/STAT pathway inhibitors generally known as Jakinibs — lessened the destructive inflammation and nerve cell degradation in the area of the brain affected by Parkinson's.

4 May 2016

Ebola vaccine shows promise in clinical trials

"The results for tolerability, safety, and the immune response to the vaccine candidate are very promising," explains Prof Marylyn Addo. The antibodies which developed against the virus were still detectable after six months. Addo is convinced, "With this, a single vaccine could provide lasting protection against Ebola." The infectious disease specialist, who works for the German Center for Infection Research at the University Medical Center Hamburg Eppendorf in Hamburg, led the trial in Hamburg.

4 May 2016

LJI study could provide important target for autoimmune disease interventions

Follicular helper T cells (Tfh cells), a rare type of T cells, are indispensable for the maturation of antibody-producing B cells. They promote the proliferation of B cells that produce highly selective antibodies against invading pathogens while weeding out those that generate potentially harmful ones.

3 May 2016

Immune Response News and Research

Landmark study characterizes evolution of symptoms, signs of acute HIV infection

Crtc switch activated during fasting helps halt spread of intestinal bacteria into bloodstream

Food components can have significant influence on immune system

Could worm infection counter IBD? An interview with Dr Loke and Dr Cadwell

Researchers reveal new mechanism that helps breast cancer cells engage MDSCs

Potential vaccine that resembles sugar structures may help fight against gut bacterium C. difficile

Mouse models of Zika virus infection in pregnancy provide basis to develop vaccines, treatments

Simultaneous DNA, RNA and protein analysis to enhance cancer immunology studies: an interview with Dr Joseph Beechem

lncRNA in placenta may help protect unborn baby from invading pathogens

Caltech researchers discover new potential cause for Crohn's disease

Research shows spleen MZ B cells produce signaling proteins involved in inflammatory responses

Study hints at new therapeutic approach to mitigate effects of prenatal Zika virus infection

New antibody-based therapy may provide better strategy for long-term control of HIV

T cell gives precise mechanical tugs to detect friends and foes

Study sheds light on development of ILCs that play vital role in body's immune defense

Duke scientists develop human-derived antibody that preferentially attacks cancer cells

Experimental drug ozanimod moderately effective in treatment of ulcerative colitis

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

Ebola vaccine shows promise in clinical trials

LJI study could provide important target for autoimmune disease interventions

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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