Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

"Luckiest man" - cured of AIDS - will have further tests

The British man thought to be the first person to have shaken off HIV, the virus that causes AIDS, is to undergo further clinical tests in the hope of a breakthrough in treating the condition.

14 Nov 2005

HIV antiretroviral therapy does help those in third world

With preliminary results from a study in Botswana, Harvard School of Public Health researchers have found that people with HIV-1 subtype C in resource-poor settings, who receive antiretroviral (ARV) therapy, can achieve comparable results to those in the developed world.

7 Nov 2005

Clinicans warned about randomized clinical trials

A review article in the November 2 issue of JAMA: The Journal of the American Medical Association, suggests clinicians ought to view with skepticism the results of randomized clinical trials stopped early because of apparent benefit.

3 Nov 2005

Drug giants join forces to develop gel for women in fight against AIDS

Giant American drug companies Merck and Bristol-Myers Squibb, have signed agreements to develop a treatment called a microbicide, a gel or a cream that women can use to protect themselves from AIDS.

2 Nov 2005

Vaginal gel shown to protect female monkeys against an HIV-like virus

Research with female monkeys at the Tulane National Primate Research Center has for the first time shown that three different anti-viral agents in a vaginal gel protect the animals against an HIV-like virus.

1 Nov 2005

Preventing pneumonia in children helps prevent pneumonia in older adults

The incidence of pneumonia among older adults has decreased substantially, linked to the introduction of a pneumonia vaccine for children in 2000, according to a study in the October 26 issue of JAMA: The Journal of the American Medical Association.

25 Oct 2005

New strategies to help developing countries address neglected diseases

For the health challenges facing developing countries, the numbers alone are staggering. Every day, 40,000 people - enough to fill a sports stadium - die from preventable infectious diseases and malnutrition. Entire generations of human potential are perishing.

25 Oct 2005

No shred of evidence that HIV-positive men who lose fat in their legs reciprocally gain fat in their bellies

There is no syndrome that causes increased belly fat and decreased facial and limb fat among HIV-positive men who take antiretroviral drugs, according to a study by researchers at the San Francisco VA Medical Center and the University of California, San Francisco.

13 Oct 2005

Evaluation of the efficacy of buprenorphine hydrochloride and clonidine hydrochloride, in detoxification of opioid-dependent teenagers

In a comparison of two drugs prescribed to treat teenagers dependent on heroin and other opioids, the drug buprenorphine was more effective, especially in treatment retention, according to a study in the October issue of Archives of General Psychiatry.

4 Oct 2005

Body's own defenses may cause HIV-related dementia

Publishing in the Sept. 2005 issue of the Journal of Virology, the researchers show that HIV in the temporal lobe mutates at a rate 100 times faster than in other parts of the body, triggering white blood cells to continually swarm to attack the infection. The associated overcrowding and inflammation appear to cause the dementia.

3 Oct 2005

Clinical trials of daily oral antiretroviral dosing as pre-exposure prophylaxis

Writing in the journal Science, an international team of researchers, clinicians and others explains that a promising, relatively new approach is for people not infected but at high risk to take drugs that might prevent them from contracting HIV. But debate over the particulars of the strategy has slowed progress.

3 Oct 2005

No specific antiretroviral drug-related "Crix belly" syndrome

Contrary to the concerns of many HIV-infected patients, there appears to be no specific antiretroviral drug-related "syndrome" of changes in body fat distribution in men wherein leg and arm fat decrease as belly fat increases, reports a study in the October issue of Journal of Acquired Immune Deficiency Syndromes (JAIDS).

28 Sep 2005

New study into the health-related quality of life for human immunodeficiency virus (HIV) patients

Pharmacists in Wales have conducted a new study into the health-related quality of life for human immunodeficiency virus (HIV) patients. The surprising results were revealed at the British Pharmaceutical Conference in Manchester.

26 Sep 2005

Screening test for cells that activate immune system

UT Southwestern Medical Center researchers are the first to create a large-scale, cell-based screening method that identifies which compounds activate immune-response cells that hold promise for future cancer-fighting vaccines.

12 Sep 2005

Unexpected link between the viruses that cause feline and human AIDS

A University of Florida researcher has discovered an unexpected link between the viruses that cause feline and human AIDS: Cats vaccinated with an experimental strain of the human AIDS virus appear to be at least as well-protected against the feline version of the disease as those immunized with the vaccine currently used by veterinarians.

10 Sep 2005

Researchers develop screening test for cells that activate immune system

7 Sep 2005

Potential new way to fight HIV

Researchers have confirmed for the first time the benefit of an innate defense system present in the few patients who remain healthy after years of infection with HIV despite receiving no treatment, according to an article published in the September edition of the Journal of Virology.

1 Sep 2005

Dental problems caused by radiation, chemotherapy should be treated before a child undergoes immunosuppression as part of bone marrow transplantation therapy

Many children who undergo bone marrow transplantation (BMT) as part of cancer treatment already have dental abnormalities that leave them vulnerable to potentially life-threatening bacterial infections, according to investigators at St. Jude Children's Research Hospital. A report on this study appears in the prepublication online edition of Bone Marrow Transplantation.

29 Aug 2005

Gene therapy advance shows potential for developing improved treatment for hemophilia

A virus that typically infects insects could help with the development of gene therapy treatment for Hemophilia A, a condition in which even a bump on the knee can cause serious internal bleeding in people.

22 Aug 2005

Infusion nurses examine need for standards of practice in immunoglobulin therapy

A review article published in the July/August 2005 Journal of Infusion Nursing examines the need for established treatment guidelines to support doctors and nurses in correctly dosing and administering intravenous immunoglobulin (IVIG) as replacement therapy in patients with primary immunodeficiency (PI) disorders, who do not produce adequate levels of antibodies essential in fighting infectious diseases.

13 Aug 2005