Immunoprecipitation News and Research

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Study finds molecular key to formation of mature and fully functioning T cells

In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report in the Journal of Experimental Medicine identifying a gene and family of proteins critical to the formation of mature and fully functioning T cells in the immune system.

25 Oct 2019

Improved antibody validation

Antibodies are used in a variety of clinical and research situations to examine the structure and function, and distribution of proteins. However, many researchers have found a lack of specificity in the functioning of these antibodies. This means that any work conducted using these antibodies will not yield reliable results.

16 Oct 2019

Early detection method for pinpointing molecular signatures of Lyme disease

When researchers examined the mitochondrial DNA of Ötzi, a man entombed in ice high in the Tyrolean Alps some 5,300 years ago, they made a startling discovery.

26 Aug 2019

'Junk' DNA mutations highly significant in autism and stroke

Non-coding DNA, junk DNA, genetic dark matter – these are all names for the 98% of DNA that doesn’t directly code for proteins but is crucial in regulating protein synthesis. This is now the focus of a large new study published in the journal Nature Genetics.

25 Jul 2019

New Chromatrap ChIP-seq kit performs chromatin immunoprecipitation with unparalleled sensitivity

Porvair Sciences announces version 2.0 of its Chromatrap® ChIP-seq kit - developed to perform chromatin immunoprecipitation with unparalleled sensitivity.

From Chromatrap® - Porvair Sciences Ltd 3 Apr 2019

New mathematical method to map cell regulatory networks

Faster results. Lower costs. Fewer cells. A new mathematical method developed by researchers at Cincinnati Children's and New York University may soon make it much easier to conduct more of the complex data analysis needed to drive advances in the exploding field of personalized medicine.

6 Mar 2019

Porvair Sciences to improve the diagnosis and treatment of ovarian cancer

Porvair Sciences reports on its involvement in a new £2.6 million project led by Swansea University (UK) that aims to dramatically improve the diagnosis and treatment of ovarian cancer.

From Chromatrap® - Porvair Sciences Ltd 27 Feb 2019

Study: BldC protein in Streptomyces acts as ‘brake’ to control timing of sporulation

Streptomyces are soil-dwelling bacteria that produce approximately two-thirds of the antibiotics in current clinical use.

6 Feb 2019

Chromatrap partners with Covaris to offer highly scalable and simple ChIP workflow

Chromatrap has entered into a partnership with Covaris to offer a highly scalable and simple ChIP workflow enabling researchers to easily isolate protein-DNA complexes for downstream applications, such as ChIP-Seq, ChIP-qPCR, Next-generation sequencing, and Mass Spectrometry.

From Chromatrap® - Porvair Sciences Ltd 30 Jan 2019

Conducting ChIP-Seq with Low Cell Numbers

An interview with Dr. Kathyrn Cunningham at SfN 2018, providing advice on carrying out Chromatin Immunoprecipitation Sequencing (ChIP-seq) with low cell numbers.

From Active Motif 14 Jan 2019

Enhancers can be predicted through ChIP-seq technology

In genetics, an enhancer is a short region of DNA that can be bound by proteins to increase the likelihood that transcription of a particular gene will occur.

23 Dec 2018

Chromatrap buffer reagents for lysing cells offer many benefits

Porvair Sciences announce how its Chromatrap Lysis and Hypotonic buffers play a crucial role in enabling researchers to better understand biological organisms.

From Chromatrap® - Porvair Sciences Ltd 13 Dec 2018

Comprehensive analysis reveals weaknesses to target in common pediatric solid tumor

St. Jude Children's Research Hospital investigators have completed the most comprehensive analysis yet of a common pediatric solid tumor, identifying weaknesses to target and a promising precision medicine that is now in clinical trials.

23 Aug 2018

Study identifies RNA molecules that regulate male hormones in prostate cancer

In most cases of prostate cancer, tumor cell growth is stimulated by the action of male hormones, or androgens, such as testosterone and dihydrotestosterone.

19 Jul 2018

Error in most widely used method in epigenetics can cause misleading results

An error in one of the most widely used methods in epigenetics, DIP-seq, can cause misleading results, researchers at Linköping University, Sweden, have shown. This may have major significance in the research field, where "big data" and advanced methods of DNA analysis are used to study vast amounts of epigenetic data.

26 Jun 2018

Study identifies new biomarker for early lung cancer diagnosis

High levels of cytoskeleton-associated protein 4 (CKAP4) have been identified in the blood of patients with lung cancer.

8 May 2018

Porvair and Suzhou Tianlong Bio to develop epigenetic analysis technologies

Porvair Sciences are teaming up with Suzhou Tianlong Bio Technology Co Ltd (China), together with Swansea University and Xi'an Jiaotong University in a collaborative project entitled, "Automating & Stratification of Epigenetics in Healthcare" that is part of the Innovate UK / Jiangsu Industrial Challenge Programme.

From Chromatrap® - Porvair Sciences Ltd 15 Dec 2017

Research shows how glutamine plays role in regulating cellular differentiation programs

The 200 different types of cells in the body all start with the same DNA genome. To differentiate into families of bone cells, muscle cells, blood cells, neurons and the rest, differing gene programs have to be turned on or off.

17 Aug 2017

Native ChIP kit from Chromatrap is now compatible for mass spectrometry

Chromatrap announces that its popular Native ChIP kit is now fully compatible for mass spectrometry (MS) as a downstream process. Combining Chromatrap®’s unique solid-state ChIP technology with MS enables researchers to obtain high quality data sets for chromatin proteomic profiling and mapping of histone modification patterns.

From Chromatrap® - Porvair Sciences Ltd 7 Aug 2017

Biolegend chooses Chromatrap technology to power chromatin immunoprecipitation kits

Chromatrap® announces that BioLegend, a major US-based manufacturer and supplier of reagents and kits for biomedical research, has chosen their novel solid-state ChIP technology to power a new range of faster and more efficient chromatin immunoprecipitation kits.

From Chromatrap® - Porvair Sciences Ltd 30 Jun 2017